The apolipoprotein E gene promoter (-219G/T) polymorphism determines insulin sensitivity in response to dietary fat in healthy young adults

Journal of Nutrition

Volumn 135, Issue 11, 2005, Pages 2535-2540

  Moreno, Juan Antonio ^a   Pérez Jiménez, Francisco ^a   Marín, Carmen ^a   Pérez Martínez, Pablo ^a   Moreno, Rafael ^a   Gómez, Purificación ^a   Jiménez Gómez, Yolanda ^a   Paniagua, Juan Antonio ^a   Lairon, Denis ^b   López Miranda, José ^a  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b INSERM   (France)

Author keywords

ApoE gene promoter ( 219G T) polymorphism; Dietary intervention; Genetics; Insulin sensitivity

Indexed keywords

APOLIPOPROTEIN A; CARBOHYDRATE; SATURATED FATTY ACID;

ADULT; ALLELE; ARTICLE; CALORIC INTAKE; CARBOHYDRATE DIET; CONCENTRATION (PARAMETERS); DNA POLYMORPHISM; FAT INTAKE; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN SENSITIVITY; NORMAL HUMAN; PLASMA; STEADY STATE; VOLUNTEER;

EID: 31544433663     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/135.11.2535     Document Type: Article

References (45)

1. Reaven, G. M. (1988) Role of insulin resistance in human disease. Diabetes 37: 1595-1607.
2. Deeb, S. S., Zambon, A., Carr, M. C., Ayyobi, A. F. & Brunzell, J. D. (2003) Hepatic lipase and dyslipidemia: interactions among genetic variants, obesity, gender, and diet. J. Lipid. Res. 44: 1279-1286.
3. Baier, L. J., Sacchettini, J. C., Knowler, W. C., Eads, J., Paolisso, G., Tataranni, P. A., Mochizuki, H., Bennett, P. H., Bogardus, C. & Prochazka, M. (1995) An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. J. Clin. Investig. 95: 1281-1287.
4. Miettinen, T. A., Gylling, H., Vanhanen, H. & Ollus, A. (1992) Cholesterol absorption, elimination, and synthesis related to LDL kinetics during fat intake in men with different apoprotein E phenotypes. Arterioscler. Thromb. 12: 1044-1052.
5. Weintraub, M. S., Eisenberg, S. & Breslow, J. L. (1987) Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E. J. Clin. Investig. 79: 1571-1577.
6. Descamps, O., Bilheimer, D. & Herz, J. (1993) Insulin stimulates receptor-mediated uptake of apoE-enriched lipoproteins and activated alpha2-macroglobulin in adipocytes. J. Biol. Chem. 268: 974-981.
7. Despres, J. P., Verdon, M. F., Moorjani, S., Pouliot, M. C., Nadeau, A., Bouchard, C., Tremblay, A. & Lupien, P. J. (1993) Apolipoprotein E polymorphism modifies relation of hyperinsulinemia to hypertriglyceridemia. Diabetes 42: 1474-1481.
8. Valdez, R., Howard, B. V., Stern, M. P. & Haffner, S. M. (1995) Apolipoprotein E polymorphism and insulin levels in a biethnic population. Diabetes Care 18: 992-1000.
9. Orchard, T. J., Eichner, J., Kuller, L. H., Becker, D. J., McCallum, L. M. & Grandits, G. A. (1995) Insulin as a predictor of coronary heart disease: interaction with apolipoprotein E phenotype. Ann. Epidemiol. 4: 40-45.
10. Kogawa, K., Nishizawa, Y., Hosoi, M., Kawagishi, T., Maekawa, K., Shoji, T., Okuno, Y. & Morii, H. (1997) Effect of polymorphism of apolipoprotein E and angiotensin-converting enzyme genes on arterial wall thickness. Diabetes 46: 682-687.
11. Laakso, M., Kesaniemi, A., Kervinen, K., Jauhiainen, M. & Pyorala, K. (1991) Relation of coronary heart disease and apolipoprotein E phenotype in patients with non-insulin dependent diabetes mellitus. Br. Med. J. 303: 1159-1162.
12. Bard, J. M., Charles, M. A., Juhan-Vague, I., Vague, P., Andre, P., Safar, M., Fruchart, J. C. & Eschwege, E. (2001) Accumulation of triglyceride-rich lipoprotein in subjects with abdominal obesity: the biguanides and the prevention of the risk of obesity (BIGPRO) 1 study. Arterioscler. Thromb. Vasc. Biol. 21: 407-414.
13. Artiga, M. J., Bullido, M. J., Sastre, I., Recuero, M., Garcia, M. A., Aldudo, J., Vazquez, J. & Valdivieso, F. (1998) Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene. FEBS Lett. 421: 105-108.
14. Lambert, J. C., Pasquier, F., Cottel, D., Frigard, B., Amouyel, P. & Chartier-Harlin, M. C. (1998) A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease. Hum. Mol. Genet. 7: 533-540.
15. Lambert, J. C., Brousseau, T., Defosse, V., Evans, A., Arveiler, D., Ruidavets, J. B., Haas, B., Cambou, J. P., Luc, G., Ducimetiere, P., Cambien, F., Chartier-Harlin, M. C. & Amouyel, P. (2000) Independent association of an APOE gene promoter polymorphism with increased risk of myocardial infarction and decreased APOE plasma concentrations-the ECTIM Study. Hum. Mol. Genet. 9: 57-61.
16. Moreno, J. A., Lopez-Miranda, J., Marin, C., Gomez, P., Perez-Martinez, P., Fuentes, F., Fernandez De La Puebla, R. A., Paniagua, J. A., Ordovas, J. M. & Perez-Jimenez, F. (2003) The influence of the apolipoprotein E gene promoter (-219G/T) polymorphism on postprandial lipoprotein metabolism. J. Lipid. Res. 44: 2059-2064.
17. Viitanen, L., Pihlajamaki, J., Miettinen, R., Karkkainen, P., Vauhkonen, I., Halonen, P., Kareinen, A., Lehto, S. & Laakso, M. (2001) Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease. J. Mol. Med. 79: 732-737.
18. Moreno, J. A., Perez-Jimenez, F., Marin, C., Gomez, P., Perez-Martinez, P., Moreno, R., Bellido, C., Fuentes, F. & Lopez-Miranda, J. (2004) The apolipoprotein E gene promoter (219G/T) polymorphism increases LDL cholesterol concentrations and susceptibility to oxidation in response to a saturated fat-rich diet. Am. J. Clin. Nutr. 80: 1404-1409.
19. Lovejoy, J. C. (2002) The influence of dietary fat on insulin resistance. Curr. Diab. Rep. 2: 435-440.
20. Luc, G., Bard, J. M., Arveiler, D., Evans, A., Cambou, J. P., Bingham, A., Amouyel, P., Schaffer, P., Ruidavets, J. B. & Cambien, F. (1994) Impact of apolipoprotein E polymorphism on lipoproteins and risk of myocardial infarction. The ECTIM Study. Arterioscler. Thromb. 14: 1412-1419.
21. Ordovas, J. M. (2001) Gene-diet interaction and plasma lipid response to dietary intervention. Curr. Atheroscler. Rep. 3: 200-208.
22. Perez-Jimenez, F., Lopez-Miranda, J., Pinillos, M. D., Gomez, P., Paz-Rojas, E., Montilla, P., Marin, C., Velasco, M. J., Blanco-Molina, A., Jimenez Pereperez, J. A. & Ordovas, J. M. (2001) A Mediterranean and a high-carbohydrate diet improve glucose metabolism in healthy young persons. Diabetologia 44: 2038-2043.
23. Human Nutrition Information Service, Department of Agriculture (1987) Composition of foods. In: Agriculture Handbook no. 8. U.S. Government Printing Office, Washington, DC.
24. Varela, G. (1980) Food Composition Tables (Tablas de Composición de Alimentos). Instituto de Nutrición CSIC, Madrid, Spain.
25. Association of Official Analytical Chemists (1990) Official Methods of Analysis, 15th ed. AOAC, Arlington, VA.
26. Ruiz-Gutierrez, V., Prada, J. L. & Perez-Jimenez, F. (1993) Determination of fatty acid and triacylglycerol composition of human very-low-density lipoproteins. J. Chromatogr. 622: 117-124.
27. Allain, C. C., Poon, L. S., Chan, C. S., Richmond, W. & Fu, P. C. (1974) Enzymatic determination of total serum cholesterol. Clin. Chem. 20: 470-475.
28. Bucolo, G. & David, H. (1973) Quantitative determination of serum triglycerides by the use of enzymes. Clin. Chem. 19: 476-482.
29. 2. Clin. Chem. 9: 2026-2030.
30. Riepponem, P., Marniemi, J. & Rautaoja, T. (1987) Immunoturbidimetric determination of apolipoproteins A-I and B in serum. Scand. J. Clin. Lab. Investig. 47: 739-744.
31. Friedewald, W. T., Levy, R. I. & Fredrickson, D. S. (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of a preparative ultracentrifuge. Clin. Chem. 18: 499-502.
32. Shimizu, S., Inoue, K., Tani, Y. & Yamada, H. (1979) Enzymatic microdetermination of serum free fatty acids. Anal. Biochem. 98: 341-345.
33. Harano, Y., Ohgaku, S., Hidaka, H., Haneda, K., Kikkawa, R., Shigeta, Y. & Abe, H. (1977) Glucose, insulin and somatostatin infusion for the determination of insulin sensitivity. J. Clin. Endocrinol. Metab. 45: 1124-1127.
34. Laws, A., Jeppesen, J. L., Maheux, P. C., Schaaf, P., Chen, Y. D. & Reaven, G. M. (1994) Resistance to insulin-stimulated glucose uptake and dyslipidemia in Asian Indians. Arterioscler. Thromb. 14: 917-922.
35. Rivellese, A. A., De Natale, C. & Lilli, S. (2002) Type of dietary fat and insulin resistance. Ann. N.Y. Acad. Sci. 967: 329-335.
36. Vessby, B., Unsitupa, M., Hermansen, K., Riccardi, G., Rivellese, A. A., Tapsell, L. C., Nalsen, C., Berglund, L., Louheranta, A., Rasmussen, B. M., Calvert, G. D., Maffetone, A., Pedersen, E., Gustafsson, I. B. & Storlien, L. H. (2001) Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study. Diabetologia 44: 312-319.
37. Steiner, G. (1991) Altering triglyceride concentrations changes insulinglucose relationships in hypertriglyceridemic patients. Double-blind study with gemfibrozil with implications for atherosclerosis. Diabetes Care 14: 1077-1081.
38. Kim, M. H., Nakayama, R., Manos, P., Tomlinson, J. E., Choi, E., Ng, J. D. & Holten, D. (1989) Regulation of apolipoprotein E synthesis and mRNA by diet and hormones. J. Lipid Res. 30: 663-671.
39. Lin-Lee, Y. C., Tanaka, Y., Lin, C. T. & Chan, L. (1981) Effects of an atherogenic diet on apolipoprotein E biosynthesis in the rat. Biochemistry 20: 6474-6480.
40. Ogbonna, G., Theriault, A. & Adeli, K. (1993) Hormonal regulation of human apolipoprotein E gene expression in HepG2 cells. Int. J. Biochem. 25: 635-640.
41. Kingle, C. M. (2001) Estrogen receptor interaction with estrogen response elements. Nucleic Acids Res. 29: 2905-2919.
42. Lambert, J. C., Cayle, N. & Lendon, C. (2004) The allelic modulation of apolipoprotein E expression by oestrogen: potential relevance for Alzheimer's disease. J. Med. Genet. 41: 104-112.
43. Bohnet, K., Pillot, T., Visvikis, S., Sabolovic, N. & Siest, G. (1996) Apolipoprotein (apo) E genotype and apoE concentration determine binding of normal very low density lipoproteins to HepG2 cell surface receptors. J. Lipid Res. 37: 1316-1324.
44. Randle, P. J., Garland, P. B., Hales, C. N. & Newsholme, E. A. (1963) The glucose fatty-acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1: 785-789.
45. Bjorntorp, P. (1994) Fatty acids, hyperinsulinemia, and insulin resistance which comes first. Curr. Opin. Lipidol. 5: 166-174.