Application of HSVtk suicide gene to X-SCID gene therapy: Ganciclovir treatment offsets gene corrected X-SCID B cells

Biochemical and Biophysical Research Communications

Volumn 341, Issue 2, 2006, Pages 391-398

  Uchiyama, Toru ^a   Kumaki, Satoru ^a   Ishikawa, Yoshinori ^b   Onodera, Masafumi ^c   Sato, Miki ^a   Du, Wei ^a   Sasahara, Yoji ^a   Tanaka, Nobuyuki ^b   Sugamura, Kazuo ^b   Tsuchiya, Shigeru ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

c chain; Gene therapy; HSVtk; Retroviral vector; Suicide gene; X SCID

Indexed keywords

GANCICLOVIR; RETROVIRUS VECTOR; THYMIDINE KINASE;

ARTICLE; B LYMPHOCYTE; CASE REPORT; CYTOTOXICITY; DNA STRAND BREAKAGE; DRUG EFFICACY; GENE EXPRESSION; GENE THERAPY; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; PRIORITY JOURNAL; SUICIDE GENE; X LINKED SEVERE COMBINED IMMUNODEFICIENCY;

ANTIVIRAL AGENTS; B-LYMPHOCYTES; CELL LINE; CELL LINE, TRANSFORMED; CELL PROLIFERATION; CELL SURVIVAL; DNA, COMPLEMENTARY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLOW CYTOMETRY; GANCICLOVIR; GENE THERAPY; GENETIC VECTORS; HUMANS; INTERLEUKIN-2; JANUS KINASE 3; LEUKOCYTES, MONONUCLEAR; MODELS, GENETIC; MUTAGENESIS; MUTATION; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RETROVIRIDAE; SEVERE COMBINED IMMUNODEFICIENCY; SIMPLEXVIRUS; THYMIDINE KINASE;

SIMPLEXVIRUS;

EID: 31444437892     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.12.199     Document Type: Article

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