Novel analgesic triglycerides from cultures of Agaricus macrosporus and other basidiomycetes as selective inhibitors of neurolysin

Journal of Antibiotics

Volumn 58, Issue 12, 2005, Pages 775-786

  Stadler, Marc ^a   Hellwig, Veronika ^a,c   Mayer Bartschmid, Anke ^a   Denzer, Dirk ^a   Wiese, Burkhard ^b   Burkhardt, Nils ^a  

^a BAYER PHARMA AG   (Germany)

^b BAYER CROPSCIENCE AG   (Germany)

^c INSTITUTE OF MATERIALS RESEARCH   (Germany)

Author keywords

Agaricoglycerides; Fermentation; Fungi; In vivo activity; Pain

Indexed keywords

4 HYDROXYBENZOIC ACID; AGARICIC ESTER; AGARICOGLYCERIDE A; AGARICOGLYCERIDE B; AGARICOGLYCERIDE C; AGARICOGLYCERIDE D; AGARICOGLYCERIDE DERIVATIVE; ANALGESIC AGENT; DICHLOROANISIC ACID; DYNORPHIN; GLYCEROL; MORPHINE; NEUROLYSIN; NEUROTENSIN; PHENOL DERIVATIVE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

AGARICUS; AGARICUS MACROSPORUS; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASIDIOMYCETES; BIOASSAY; CONTROLLED STUDY; DERIVATIZATION; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG SYNTHESIS; FERMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HYPHOLOMA; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSATHYRELLA; STROPHARIA; STRUCTURE ANALYSIS;

AGARICUS; ANALGESICS; ANIMALS; BASIDIOMYCOTA; BEHAVIOR, ANIMAL; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CULTURE MEDIA; ENZYME INHIBITORS; FERMENTATION; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METALLOENDOPEPTIDASES; PAIN MEASUREMENT; RATS; RATS, WISTAR; SPECTROPHOTOMETRY, ULTRAVIOLET; TRIGLYCERIDES;

AGARICUS; AGARICUS MACROSPORUS; ANIMALIA; BASIDIOMYCOTA; FUNGI; HYPHOLOMA; PSATHYRELLA; STROPHARIA;

EID: 31444435431     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2005.105     Document Type: Article

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