A multicenter, placebo-controlled, double-blind study of efficacy of a new form of carbamazepine (CarbatrolR) in refractory epileptic patients

Polish Journal of Pharmacology

Volumn 56, Issue 2, 2004, Pages 195-201

  Sobaniec, Wojciech ^a   Kułak, Wojciech ^a   Śmigielska Kuzia, Joanna ^a   Boćkowski, Leszek ^b   Majkowski, Jerzy ^b   Jedrzejczak, Joanna ^b  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^b MEDICAL CENTER FOR POSTGRADUATE EDUCATION   (Poland)

Author keywords

Carbamazepine; Carbatrol; Epilepsy; Uncontrolled partial seizures

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CLORAZEPATE; PHENOBARBITAL; PHENYTOIN; PLACEBO; VALPROIC ACID;

ADULT; ARTICLE; ATAXIA; BRONCHITIS; CLINICAL ARTICLE; CLINICAL TRIAL; COMMON COLD; COMPLEX PARTIAL SEIZURE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIPLOPIA; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; EPILEPSY; FEMALE; FOCAL EPILEPSY; HEADACHE; HUMAN; INCREASED APPETITE; MALE; MEMORY DISORDER; MIGRAINE; MULTICENTER STUDY; NERVOUSNESS; NYSTAGMUS; OUTPATIENT; PHARYNGITIS; POLAND; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SOMNOLENCE; SUSTAINED DRUG RELEASE; TONIC CLONIC SEIZURE; TREMOR; VERTIGO;

ADOLESCENT; ADULT; CARBAMAZEPINE; CHEMISTRY, PHARMACEUTICAL; CHI-SQUARE DISTRIBUTION; DELAYED-ACTION PREPARATIONS; DOUBLE-BLIND METHOD; EPILEPSY; FEMALE; HUMANS; MALE; MIDDLE AGED;

EID: 3142769870     PISSN: 12306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Artemowicz B, Sołowiej E, Sobaniec W: The use of carbamazepine in psychiatry (Polish). Białost Bibl Padaczki, 1996, 1, 53-61.
2. Bertilsson L, Hojer B, Tybring G, Osterloh J, Rane A: Autoinduction of carbamazepine metabolism in children examined by a stable isotope technique. Clin Pharmacol Ther, 1980, 27, 83-88.
3. Borowicz KK, Gasior M, Kocki T, Błaszczak P, Turski WA, Kleinrok Z, Czuczwar SJ: Anticonvulsant activity, adverse effects and plasma levels of conventional antiepileptic drugs at different times after single administration. Pol J Pharmacol, 1997, 49, 69.
4. Borowicz KK, Wilczyński PM, Kleinrok Z, Czuczwar SJ: Influence of aminophylline on the protective activity of carbamazepine against amygdala-kindled seizures in rats. Pol J Pharmacol, 1998, 50, 90-91.
5. Chadwik D: Monotherapy comparative trials: equivalence and differences in clinical trials. Epilepsy Res, 2001, 45, 101-103.
6. Dhalla Z, Bruni J, Sutton J: A comparison of the efficacy and tolerability of controlled-release carbamazepine with conventional carbamazepine. Can J Neurol Sci, 1991, 18, 66-68.
7. Gibbons I, Gorin M, Yassinzadeh Z, Peterson P, Besemer D, Dillon K, Burd T et al.: Patient-side immunoassay system with a single-use cartridge for measuring analytes in blood. Clin Chem, 1989, 35, 1869-1873.
8. Hoeppener RJ, Kuyer A, Meijer JWA, Hulsman J: Correlation between daily fluctuations of carbamazepine serum levels and intermittent side-effects. Epilepsia, 1980, 21, 341-350.
9. Jensen PK, Moller A, Gram L, Jensen NO, Dam M: Pharmacokinetic comparison of two carbamazepine slow-release formulations. Acta Neurol Scand, 1990, 82, 135-137.
10. Kułak W, Sobaniec W, Sołowiej E, Chrzanowska B: Tegretol CR and ditropan: their tolerance and efficacy in the treatment of nocturnal enuresis in an open study (Polish). Białost Bibl Padaczki, 1996, 1, 45-52.
11. Levy RH, Lai AA: A pharmacokinetic model for drug interactions by enzyme induction and its application to carbamazepine-clonazepam. In: Antiepileptic Therapy: Advances in Drug Monitoring, Ed. Johannessen SI, Morseli PL, Pipenger CE, Richens A, Schmidt D, Meinardi H, Raven Press, New York, 1980, 315-323.
12. Macphee GJA, Butler E, Brodie MJ: Intradose and circadian variation in circulating carbamazepine and its epoxide in epileptic patients: a consequence of autoinduction of metabolism. Epilepsia, 1987, 28, 286-294.
13. Malek R, Borowicz KK, Kimber-Trojnar Z, Sobieszek G, Piskorska B, Czuczwar SJ: Remacemide - a novel potential antiepileptic drug. Pol J Pharmacol, 2003, 55, 691-698.
14. Ryan SW, Forsythe I, Hartley R, Haworth M, Bowmer CJ: Slow release carbamazepine in treatment of poorly controlled seizures. Arch Dis Child, 1990, 65, 930-935.
15. Sendrowski K, Sobaniec W: The retard form of drugs and their pharmaco-therapeutic role (Polish). Białost Bibl Padaczki, 1996, 1, 91-97.
16. Sillanpaa M: Carbamazepine. Pharmacology and clinical uses. Acta Neurol Scand Suppl, 1981, 88, 1-202.
17. Sobaniec W, Kułak W, Łotowska-Sobaniec M: Pharmacokinetics of antiepileptic drugs in children (Polish). Neurologia Dziecieca, 1993, 2, 77-83.
18. Sobaniec W, Jankowicz E, Boćkowski L: Carbamazepine. The new forms, new applications (Polish). Białost Bibl Padaczki, 1996, 1.
19. Sobieszek G, Borowicz KK, Kimber-Trojnar Z, Malek R, Piskorska B, Czuczwar SJ: Zonisamide: a new antiepileptic drug. Pol J Pharmacol, 2003, 55, 683-689.
20. Syrek M, Wójcikowski J, Daniel W: Effect of carbamazepine on the pharmacokinetics of promazine. Pol J Pharmacol, 1996, 48, 601-608.
21. Theisohn M, Assion HJ, Werner U: Influence of breakfast and day time on the disposition of carbamazepine in healthy volunteers after intake of a single dose (600 mg) of a standard or retard preparation of carbamazepine. In: Chronopharmacology in Therapy of the Epilepsies. Ed. Dreifuss FE, Meinardi H, Stefan H, Raven Press, New York, 1990, 31-53.