Use of a modified Leimgruber-Batcho reaction to prepare 6-chloro-5-fluoroindole

Synthetic Communications

Volumn 34, Issue 12, 2004, Pages 2295-2301

  Bentley, Jon M ^a   Davidson, James E ^a   Duncton, Matthew A J ^a,b   Giles, Paul R ^a   Pratt, Robert M ^a  

^a Vernalis PLC   (United Kingdom)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

5 HT2C receptor; Indole; Leimgruber Batcho; Ro 60 0175

Indexed keywords

2 (6 CHLORO 5 FLUORO 1 INDOLYL) 1 METHYLETHYLAMINE; 6 CHLORO 5 FLUOROINDOLE; CHLORINE DERIVATIVE; FLUORINE DERIVATIVE; HETEROCYCLIC COMPOUND; INDOLE DERIVATIVE; SEROTONIN 2C AGONIST; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; LEIMGRUBER BATCHO REACTION; REACTION ANALYSIS; STEREOSPECIFICITY; SUBSTITUTION REACTION; SYNTHESIS;

EID: 3142764456     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1081/SCC-120038513     Document Type: Article

References (6)

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6. Bentley, J.M.; Dawson, C.E.; George, A.R.; Hamlyn, R.J.; Pratt, R.M.; Gaur, S.; Adams, D.R.; Bebbington, D.; Duncton, M.A.J. Preparation of Indolinealkylamine Derivatives as 5-HT2B and/or 5-HT2C Receptor Ligands. European Patent 1,109,784, 1 September 1999.