Effects of tegaserod on Fos, substance P and calcitonin gene-related peptide expression induced by colon inflammation in lumbarsacral spinal cord

World Journal of Gastroenterology

Volumn 10, Issue 12, 2004, Pages 1830-1833

  Sun, Yi Ning ^a   Luo, Jin Yan ^a  

^a THE SECOND AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; PROTEIN FOS; SEROTONIN 4 AGONIST; SODIUM CHLORIDE; SUBSTANCE P; TEGASEROD; TRINITROBENZENESULFONIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LABELING; COLITIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LUMBOSACRAL SPINE; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL;

EID: 3142752169     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v10.i12.1830     Document Type: Article

References (19)

1. Bueno L, Fioramonti J, Delvaux M, Frexinos J. Mediators and pharmacology of visceral sensitivity: from basic to clinical investigations. Gastroenterology 1997; 112: 1714-1743
2. Lacy BE, Yu S. Tegaserod: a new 5-HT4 agonist. J Clin Gastroenterol 2002; 34: 27-33
3. Lu Y, Westlund KN. Effects of baclofen on colon inflammation-induced Fos, CGRP and SP expresson in spinal cord and brainstem. Brain Res 2001; 889: 118-130
4. Mertz H, Naliboff B, Munakata J, Niazi N, Mayer EA. Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology 1995; 109: 40-52
5. Muller-Lissner SA, Fumagalli I, Bardhan KD, Pace F, Pecher E, Nault B, Ruegg P. Tegaserod, a 5-HT(4) receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation. Aliment Pharmacol Ther 2001; 15: 1655-1666
6. Novick J, Miner P, Krause R, Glebas K, Bliesath H, Ligozio G, Ruegg P, Lefkowitz M. A randomized double-blind, placebo-controlled trial of tegaserod in female patients suffering from irritable bowel syndrome with constipation. Aliment Pharmacol Ther 2002; 16: 1877-1888
7. Coffin B, Farmachidi JP, Rueegg P, Bastie A, Bouhasira D. Tegaserod, a 5-HT4 receptor partial agonist, decreases sensitivity to rectal distension in healthy subjects. Aliment Pharmacol Ther 2003; 17: 577-585
8. Traub RJ, Pechman P, Iadarola MJ, Gebhart GF. Fos-like proteins in the lumbosacral spinal cord following noxious and non-noxious colorectal distention in the rat. Pain 1992; 49: 393-403
9. Traub RJ, Stitt S, Gebhart GF. Attenuation of c-Fos expression in the rat lumbosacral spinal cord by morphine or tramadol following noxious colorectal distention. Brain Res 1995; 701: 175-182
10. Traub RJ, Murphy A. Colonic inflammation induces fos expression in the thoracolumbar spinal cord increasing activity in the spinoparabrachial pathway. Pain 2002; 95: 93-102
11. Imbe H, Iwata K, Zhou QQ, Zuo S, Dubner R, Ren K. Orofacial deep and cutaneous tissue inflammation and trigeminal neuronal activation. Implications for persistent temporomandibular pain. Cells Tissues Organs 2001; 169: 238-247
12. Palecek J, Paleckova V, Willis WD. Postsynaptic dorsal column neurons express NK1 receptors following colon inflammation. Neuroscience 2003; 116: 565-572
13. Kishimoto S, Kobayash H, Machino H. High-concentrations of substance P as a possible transmission of abdominal pain in rats with chemical induced ulcerative colitis. Biomed Res 1994; 15: 133-140
14. Bueno L, Fioramonti J. Effects of inflammatory mediators on gut sensitivity. Can J Gastroenterol 1999; 13(Suppl A): 42A-46A
15. Coderre TJ, Katz J, Vaccarino AL, Melzack R. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 1993; 52: 259-285
16. Friese N, Diop L, Chevalier E, Angel F, Riviere PJ, Dahl SG. Involvement of Prostaglandins and CGRP-dependent sensory afferents in peritoneal irritation-induced visceral pain. Regul Pept 1997; 70: 1-7
17. Schikowski A, Thewissen M, Mathis C, Ross HG, Enck P. Serotonin type-4 receptors modulate the sensitivity of intramural mechanoreceptive afferents of the cat rectum. Neurogastroenterol Motil 2002; 14: 221-227
18. Gyermek L. Pharmacology of serotonin as related to anesthesia. J Clin Anesth 1996; 8: 402-425
19. Ghelardini C, Galeotti N, Casamenti F, Malmberg-Aiello P, Pepeu G, Gualtieri F, Bartolini A. Central cholinergic antinociception induced by 5-HT4 agonists: BIMU1 and BIMU8. Life Sci 1996; 58: 2297-2309