Optimization and metabolic stabilization of a class of nonsteroidal glucocorticoid modulators

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 16, 2004, Pages 4169-4172

  Link, J T ^a   Sorensen, Bryan K ^a   Patel, Jyoti ^a   Arendsen, David ^a   Li, Gaoquan ^a   Swanson, Susan ^a   Nguyen, Bach ^a   Emery, Maurice ^a,c   Grynfarb, Marlena ^b   Goos Nilsson, Annika ^b  

^a ABBOTT LABORATORIES   (United States)

^b Karo Bio   (Sweden)

^c AMGEN INC   (United States)

Author keywords

Antidiabetic; Glucocorticoid modulator

Indexed keywords

ANTIDIABETIC AGENT; GLUCOCORTICOID RECEPTOR ANTAGONIST; MIFEPRISTONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DRUG BINDING; DRUG METABOLISM; NONHUMAN; RAT;

HUMANS; LIGANDS; PROTEIN BINDING; RECEPTORS, GLUCOCORTICOID;

EID: 3142732043     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.06.023     Document Type: Article

References (7)

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4. Tu, N.; Link, J. T.; Sorensen, B. K.; Emery, M.; Grynfarb, M.; Goos-Nilsson, A.; Nguyen, B. Bioorg. Med. Chem. Lett. 2004, 14, in press. doi:10.1016/j.bmcl.2004.06.022
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6. Sorensen B.K., Link J.T., von Geldern T., Emery M., Wang J., Hickman B., Grynfarb M., Goos-Nilsson A., Carroll S. Bioorg. Med. Chem. Lett. 13:2003;2307-2310
7. Friedman J.E., Sun Y., Ishizuka T., Farrell C.J., McCormack S.E., Herron L.M., Hakimi P., Lechner P., Yun J.S. J. Biol. Chem. 272:1997;31475-31481