Assessment of gastrointestinal function and response to megesterol acetate in subjects with gastrointestinal cancers and weight loss

Supportive Care in Cancer

Volumn 12, Issue 7, 2004, Pages 503-510

  Deutsch, John ^a,b   Kolhouse, J Fred ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b Duluth Clinic   (United States)

Author keywords

Cancer associated cachexia syndrome; Digestive function; Gastrointestinal cancer; Megesterol acetate

Indexed keywords

ALBUMIN; APPETITE STIMULANT; CAROTENE; CYTOKINE; MEGESTROL ACETATE; PREALBUMIN; STABLE ISOTOPE;

ADULT; ADVANCED CANCER; AGED; ALBUMIN BLOOD LEVEL; ANOREXIA; ARTICLE; BODY WEIGHT; CACHEXIA; CLINICAL ARTICLE; CLINICAL TRIAL; CORRELATION ANALYSIS; DIGESTIVE SYSTEM CANCER; DIGESTIVE SYSTEM FUNCTION DISORDER; DISEASE ASSOCIATION; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG SCREENING; FEMALE; FOLLOW UP; FUNCTIONAL ASSESSMENT; GASTROINTESTINAL TRACT FUNCTION; HUMAN; MALE; NUTRITIONAL PARAMETERS; NUTRITIONAL STATUS; OUTCOMES RESEARCH; PANCREAS FUNCTION TEST; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; TECHNIQUE; WEIGHT GAIN; WEIGHT REDUCTION;

EID: 3142731384     PISSN: 09414355     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00520-004-0615-4     Document Type: Article

References (30)

1. Beller E, Tattersall M, Lumley T, Levi J, Dalley D, Olver I, Page J, Abdi E, Wynne C, Friedlander M, Boadle D, Wheeler H, Margrie S, Simes RJ (1997) Improved quality of life with megestrol acetate in patients with endocrine-in-sensitive advanced cancer: a randomised placebo-controlled trial. Australasian Megestrol Acetate Cooperative Study Group. Ann Oncol 8:277-283
2. Bragelmann R, Armbrecht U, Resemeyer D, Schneider B, Zilly W, Stockbrugger RW (1996) Nutrient malassimilation following total gastrectomy. Scan J Gastroenterol [Suppl] 218:26-33
3. Bruno MJ, Haverkort EB, Tijssen GP, Tytgat GN, van Leeuwen DJ (1998) Placebo controlled trial of enteric coated pancreatin microsphere treatment in patients with unresectable cancer of the pancreatic head region. Gut 42:92-96
4. Bruno MJ, Hoek FJ, Delzenne B, van Leeuwen DJ, Schteingart CD, Hafmann AF, Tytgat GN (1995) Simultaneous assessments of exocrine pancreatic function by cholestryl-[14C]octanoate breath test and measurement of plasma p-aminobenzoic acid. Clin Chem 41:599-604
5. Burrowes JD, Bluestone PA, Wang J. Pierson RN Jr (1999) The effects of moderate doses of megestrol acetate on nutritional status and body composition in a hemodialysis patient. J Ren Nutr 9:89-94
6. Caras S, Laurie S, Cronk W, Tompkins W, Brashear R, McCallum RW (1996) Case report: pancreatic cancer presenting with paraneoplastic gastroparesis. Am J Med Sci 312:34-36
7. Carlson SJ, Deutsch JC, Craig RM (1998) Physiologic response to a protein, carbohydrate, fat meal in patients with immunodeficiency virus who underwent small intestinal enteropathy as characterized by a kinetic model of D-xylose absorption. JPEN J Parenter Enteral Nutr 22:27-30
8. Craig RM, Atkinson AJ Jr (1988) D-xylose testing: a review. Gastroenterology 95:223-231
9. Craig RM, Ehrenpreis ED (1999) D-xylose testing. J Clin Gastroenterol 29:143-150
10. Davis MP (2002) New drugs for the anorexia-cachexia syndrome. Curr Oncol Rep 4:264-274
11. Deutsch JC, Santhosh-Kumar CR, Kolli VR (1995) A noninvasive stable-isotope method to simultaneously assess pancreatic exocrine function and small bowel absorption. Am J Gastroenterol 12:2182-2185
12. Deutsch JC (1998) Normal digestive physiology and the evaluation of digestive function. Semin Oncol 2 [Suppl 6]:4-11
13. Ghaneh P, Neoptolemos JP (1999) Exocrine pancreatic function following pancreatectomy. Ann NY Acad Sci 880:308-318
14. Harte C, Henry MT, Murphy KD, Mitchell TH (1995) Progestogens and Cushing's syndrome. Ir J Med Sci 164:274-275
15. Hoek FJ, van den Bergh FA, Lein Elhorst JT, Meiher JL, Timmer E, Tytgat GN (1987) Improved specificity of the PABA test with p-aminosalicylic acid (PAS). Gut 28:468-473
16. Kataoka K, Yamane Y, Kato M, Kashima K (1997) Diagnosis of chronic pancreatitis using noninvasive tests of exocrine pancreatic function-comparison to duodenal intubation tests. Pancreas 15:409-415
17. Lautenbach E, Lichtenstein GR (1995) Retroperitoneal leiomyosarcoma and gastroparesis: a new association and review of tumor-associated intestinal pseudo-obstruction. Am J Gastroenterol 90:1338-1341
18. Lelli G, Montanari M, Gilli G, Scapoli D, Antonietti C, Scapoli D (2003) Treatment of the cancer anorexia-cachexia syndrome: a critical reappraisal. J Chemother 15:220-225
19. Mantovani G, Maccio A, Lai P, Massa E, Ghiani M, Santona MC (1998) Cytokine involvement in cancer anorexia/cachexia: role of megesterol acetate and medroxyprogesterone acetate on cytokine downregulation and improvement of clinical symptoms. Crit Rev Oncog 9:99-106
20. Mantovani G, Maccio A, Lai P, Massa E, Ghiani M, Santona MC (1998) Cytokine activity in cancer-related anorexia/cachexia: role of megestrol acetate and medroxyprogesterone acetate. Semin Oncol 25:45-52
21. Mc Millan DC, O'Gorman P, Fearon KC, McArdle CS (1997) A pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients. Br J Cancer 76:788-790
22. McMillan DC, Wigmore SJ, Fearon KC, O'Gorman P, Wright CE, McArdle CS (1999) A prospective randomized study of megesterol acetate and ibuprofen in gastrointestinal cancer patients with weight loss. Br J Cancer 79:495-500
23. Mee AS, Girdwood AH, Walker E, Gilinsky NH, Kottler RE, Marks IN (1985) Comparison of the oral (PABA) pancreatic function test, the secretin- pancreozymin test and endoscopic retrograde pancreatography in chronic alcohol induced pancreatitis. Gut 26:1257-1262
24. Meyer BM, Campbell DR, Curington CW, Toskes PP (1987) Bentiromide test is not affected in patients with small bowel or liver disease. Pancreas 2:44-47
25. Perez De Oteyza C, Garcia Cortes A, Menendex Martinez MA, Torres Leon JM, Perez Aznar C, Carnicero Bujarrabal M (1998) [Megestrol in the treatment of AIDS associated cachexia. Evaluation by bioelectric impedance analysis of body composition]. An Med Interna 15:255-258
26. Selby S (1970) Standard mathematical tables, 18th edn. Chemical Rubber Company, Cleveland, p 610
27. Smith GM, Chesner IM, Asquith P, Leyland MJ (1990) Small intestinal bacterial overgrowth in patients with chronic lymphocytic leukaemia. J Clin Pathol 43:58-59
28. Tisdale MJ (2003) Pathogenesis of cancer cachexia. J Support Oncol 1:159-168
29. Westman G, Bergman B, Albertsson M, Kadar L, Gustavsson G, Thaning L, Andersson M, Straumits A, Jeppson B, Linden CJ, Ewers SB, Andersson H, Mercke C, Hafstrom L, Birck O, Orgum P (1999) Megesterol acetate in advanced, hormone-insensitive cancer. Effects on the quality of life: a placebo-controlled, randomized multicentre trial. Eur J Cancer 35:586-595
30. Yeh SS, Wu SY, Lee TP, Olson JS, Stevens MR, Dixon T, Porcelli RJ, Schuster MW (2000) Improvement in quality-of-life measures and stimulation of weight gain after treatment with megestrol acetate oral suspension in geriatric cachexia: results of a double-blind, placebo-controlled study. J Am Geriatr Soc 48:485-492