Stability and analgesic efficacy of di-acetyl morphine (diamorphine) compared with morphine in implanted intrathecal pumps in vivo

Neuromodulation

Volumn 7, Issue 3, 2004, Pages 197-200

  Raphael, Jon H ^a,b   Palfrey, Stephen M ^a   Rayen, Arasu ^a   Southall, Jane L ^a   Labib, Maurad H ^a  

^a DUDLEY GROUP OF HOSPITALS NHS TRUST   (United Kingdom)

^b The Guest Hospital   (United Kingdom)

Author keywords

Diamorphine; Drug stability; Intrathecal drug delivery system; Morphine; Pain

Indexed keywords

BUPIVACAINE; CLONIDINE; DIAMORPHINE; MONOACETYL MORPHINE; MORPHINE; MORPHINE DERIVATIVE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANALYSIS OF VARIANCE; ARTICLE; CLINICAL ARTICLE; DRUG DETERMINATION; DRUG EFFICACY; DRUG HALF LIFE; DRUG METABOLISM; DRUG STABILITY; HUMAN; IMPLANTABLE PORT SYSTEM; IMPLANTATION; IN VIVO STUDY; INFUSION PUMP; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; MICELLE; PAIN; PAIN ASSESSMENT; PROSPECTIVE STUDY; RATING SCALE; SCORING SYSTEM;

EID: 3142717508     PISSN: 10947159     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1094-7159.2004.04205.x     Document Type: Article

References (9)

1. Williams JE, Louw G, Towlerton G. Intrathecal pumps for giving opioids in chronic pain. Health Technol Assess 2000;4:32.
2. Wulf H, Gleim M, Mignat C. The stability of mixtures of morphine hydrochloride, bupivacaine hydrochloride and clonidine hydrochloride in portable pump reservoirs for the management of chronic pain syndromes. J Pain Symptom Manage 1994;9:308-311.
3. Kleinberg ML, Duafala ME, Nacov C, et al. Stability of heroin hydrochloride in infusion devices and containers for intravenous administration. Am J Hospital Pharm 1990;47:377-381.
4. Yaksh TL, Hassenbusch S, Burchiel K, Hildebrand KR, Page LM, Coffey RJ. Inflammatory masses associated with intrathecal drug infusion: A review of preclinical evidence and human data. Pain Med 2002;3:300-312.
5. Raphael JH, Southall JL, Gnanadurai TV, Treharne GJ, Kitas GD. Long-term experience with implanted intrathecal drug administration systems for failed back syndrome and chronic mechanical low back pain. BMC Musculoskelet Disord 2002;3:17.
6. Suzuki R, Chapman V, Dickenson AH. The effectiveness of spinal and systemic morphine on rat dorsal horn neuronal responses in the spinal nerve ligation model of neuropathic pain. Pain 1999;80:215-228.
7. Wang JK, Nauss LA, Thomas TE. Pain relief by intrathecally applied morphine in man. Anesthesiology 1979;50:149-151.
8. Yaksh TL, Horais KA, Tozier NA, et al. Chronically infused intrathecal morphine in dogs. Anesthesiology 2003;99:174-187.
9. Hassenbusch S, Burchiel K, Coffey RJ, et al. Management of intrathecal catheter-tip inflammatory masses: a consensus statement. Pain Med 2002;3:313-323.