Synthesis of tritiated Cyclosporin A and FK-506 by metal-catalyzed hydrogen isotope exchange

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 47, Issue 7, 2004, Pages 407-414

  Shevchenko, V P ^a   Nagaev, I Yu ^a   Myasoedov, N F ^a   Andres, H ^b   Moenius, T ^b   Susan, A ^c  

^a INSTITUTE OF MOLECULAR GENETICS   (Russian Federation)

^b NOVARTIS PHARMA AG   (Switzerland)

^c Intl Isotopes Clearing House Inc ^*  (United States)

Author keywords

Cyclosporin A; FK506; H T exchange; Labeling; Tritium

Indexed keywords

CATALYSIS; HYDROGEN;

CYCLOSPORIN A; H/T-EXCHANGE; HIGH SPECIFIC ACTIVITIES; HYDROGEN ISOTOPE EXCHANGE; LABELINGS; METAL-CATALYZED; SPECIFIC ACTIVITY; TRITIATED WATER;

TRITIUM;

2 BUTANONE; ACETIC ACID; ACETIC ACID ETHYL ESTER; ACETONE; ALPRAZOLAM; ALUMINUM OXIDE; AMMONIA; BARIUM SULFATE; BENZENE; CHLOROFORM; COENZYME A; CYCLOSPORIN A; CYCLOSPORIN A H 3; DIOXANE; HEXANE; METHANOL; PALLADIUM; PROPANOL; SILICA GEL; TACROLIMUS; TERT BUTYL ALCOHOL; TIAZOFURIN; TRITIUM; TRITIUM OXIDE; TSUKUBAENOLIDE H 3; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYST; DRUG PURIFICATION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; SCINTILLATION COUNTING; THIN LAYER CHROMATOGRAPHY;

TRITIUM;

EID: 3142711502     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.827     Document Type: Article

References (13)

1. Hinz HR, Harris NJ, Giovanella BC, Ezell EL, Liehr JG. J Label Compd Radiopharm 1996; 38: 733-742.
2. Kolbe A, Schneider B, Voigt B, Adam G. J Label Compd Radiopharm 1998; 41: 131-139.
3. Leseticky L, Sedlak K, Fiser B. Radioisotopy 1990; 31: 163-169.
4. Shevchenko VP, Nagaev IYu, Potapova AV, Myasoedov NF. Radiochemistry 1998; 40: 74-78.
5. Shevchenko VP, Nagaev IYu, Myasoedov NF, Susan A. Abstract of Sixth International Symposium on The Synthesis and Applications of Isotopes and Isotopically Labeled Compounds (ISSAIILC6). Philadelphia, Pennsylvania, 1997; 73.
6. Shevchenko VP, Nagaev IYu, Myasoedov NF. Radiochemistry 1998; 40: 83-87.
7. Shevchenko VP, Nagaev IYu, Myasoedov NF. Isotopic exchange with tritiated water. In Lipophilic Compounds Labelled with Tritium, Fedoseev VM (ed.). Nauka: Moscow, 2003: 38-42 (in Russian).
8. Moenius Th, Andres H, Acemoglu M, Kohler B, Schnelli P, Zueger C. J Label Compd Radiopharm 2000; 43: 113.
9. Shevchenko VP, Myasoedov NF. In Isotopes in the Physical and Biochemical Sciences, Buncel E, Jones JR (eds), vol. 1. Labelled Compounds (Part A). Elsevier: NY, USA, 1987; 237.
10. Shevchenko VP, Myasoedov NF. In Isotopes in the Physical and Biochemical Sciences, Buncel E, Jones JR (eds), vol. 1. Labelled Compounds (Part B). Elsevier: NY, USA, 1991; 179.
11. Shevchenko VP, Nagaev IYu, Potapova AV, Myasoedov NF. Radiochemistry 1994; 36: 486-489.
12. Shevchenko VP, Nagaev IYu, Potapova AV, Myasoedov NF. Radiochemistry 1995; 37(3): 244-247.
13. Bruelisauer A. Unpublished results.