Stabilities of 3H- and 2H-labelled camptothecins

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 38, Issue 8, 1996, Pages 733-742

  Hinz, Hellmuth R ^a   Harris, Nicholas J ^a   Giovanella, Bepplno C ^a   Ezell, Edward L ^b   Liehr, Joachim G ^b  

^a St Joseph's Medical Center Houston   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Camptothecin; Deuterium labeled camptothecin; Tritiated camptothecin

Indexed keywords

BODY FLUIDS; TRITIUM;

CAMPTOTHECINS; DEUTERIUM-LABELED CAMPTOTHECIN; IN-VIVO; PHARMACOKINETIC STUDIES; TRITIATED CAMPTOTHECIN;

DEUTERIUM;

CAMPTOTHECIN H 2; CAMPTOTHECIN H 3; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG STABILITY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; ORAL DRUG ADMINISTRATION;

TRITIUM;

EID: 0029987619     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1344(199608)38:8<733::AID-JLCR888>3.0.CO;2-6     Document Type: Article

References (13)

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11. 3b. The numbering system of CPT used in this text is the same as proposed by Tang, C.S.F., Morrow, C.J. and Rapoport, H. J. Am. Chem. Soc. 97: 159-167 (1975) and as shown below. This numbering system has been adopted by Wall and coworkers (3a) and by cancer researchers and clinicians working with CPT and its derivatives. This numbering system of CPT differs from that in the Merck Index (Merck & Co., Inc., Rahway, NJ) as used in the Moravek Biochemicals catalog. equation presented
12. Hinz, Hellmuth, R. US-Patent, "Methods for purifying camptothecin compounds". No. 5352,789. Oct. 4, 1994.
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