Analysis of Ehrlichia ruminantium-specific T1/T2 responses during vaccination with a protective killed vaccine and challenge of goats

Parasite Immunology

Volumn 26, Issue 2, 2004, Pages 95-103

  Esteves, I ^a   Vachiery N ^a   Martinez, D ^a   Totte P ^a  

^a CIRAD   (France)

Author keywords

Ehrlichia ruminantium; Goats; Immunity; Killed vaccine; T1; T2

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INACTIVATED VACCINE; INTERLEUKIN 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; EHRLICHIA RUMINANTIUM; GOAT; IMMUNE RESPONSE; IMMUNIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL; VACCINATION;

ANIMALS; BACTERIAL VACCINES; EHRLICHIA RUMINANTIUM; FLOW CYTOMETRY; GOAT DISEASES; GOATS; HEARTWATER DISEASE; INTERFERON TYPE II; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; TH1 CELLS; TH2 CELLS; VACCINATION; VACCINES, INACTIVATED;

ANIMALIA; BACTERIA (MICROORGANISMS); CAPRA HIRCUS; EHRLICHIA; EHRLICHIA RUMINANTIUM; RICKETTSIALES;

EID: 3142692027     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0141-9838.2004.00688.x     Document Type: Article

References (37)

1. Uilenberg G. Heartwater (Cowdria ruminantium infection): current status. Adv Vet Sci Comp Med 1983; 27: 427-480.
2. Prozesky L. The pathology of heartwater. III. A review. Onderstepoort J Vet Res 1987; 54: 281-286.
3. Martinez D, Maillard JC, Coisne S, Sheikboudou C & Bensaid A. Protection of goats against heartwater acquired by immunisation with inactivated elementary bodies of Cowdria ruminantium. Vet Immunol Immunopathol 1994; 41: 153-163.
4. Mahan SM, Andrew HR, Tebele N, Burridge MJ & Barbet AF. Immunisation of sheep against heartwater with inactivated Cowdria ruminantium. Res Vet Sci 1995; 58: 46-49.
5. Totté P, McKeever D, Martinez D & Bensaid A. Analysis of T-cell responses in cattle immunised against heartwater by vaccination with killed elementary bodies of Cowdria ruminantium. Infect Immun 1997; 65: 236-241.
6. Mena A, Ioannou XP, Van Kessel A, et al. Th1/Th2 biasing effects of vaccination in cattle as determined by real-time PCR. J Immunol Meth 2002; 263: 11-21.
7. Rhodes SG & Graham S. Is timing important for cytokine polarization? Trends Immunol 2002; 23: 246-249.
8. Cheevers WP, Beyer JC & Knowles DP. Type 1 and type 2 cytokine gene expression by viral gp 135 surface protein-activated T lymphocytes in caprine arthritis-encephalitis lentivirus infection. J Virol 1997; 71: 6259-6263.
9. Byrom B, Obwolo M, Barbet AF & Mahan SM. A polarised Th1 type immune response to Cowdria ruminantium infection is detected in immune DBA/2 mice. J Parasitol 2000; 86: 983-992.
10. Nyika A, Barbet AF, Burridge MJ & Mahan SM. DNA vaccination with map1 gene followed by protein boost augments protection against challenge with Cowdria ruminantium, the agent of heartwater. Vaccine 2002; 20: 1215-1225.
11. Nyika A, Mahan SM, Burridge MJ, McGuire TC, Rurangirwa F & Barbet AF. A DNA vaccine protects mice against the rickettsial agent Cowdria ruminantium. Parasite Immunol 1998; 20: 111-119.
12. Mwangi DM, Mahan SM, Nyanjui JK, Taracha EL & McKeever DJ. Immunisation of cattle by infection with Cowdria ruminantium elicits T lymphocytes that recognize autologous, infected endothelial cells and monocytes. Infect Immun 1998; 66: 1855-1860.
13. +-enriched T-cells to proliferate and produce interferon-gamma. Vet Microbiol 2002; 85: 259-273.
14. + T lymphocytes in goats. Vet Immunol Immunopathol 2004; 98: 49-57.
15. Martinez D, Swinkels J, Camus E & Jongejan F. Comparison between 3 antigens for the serodiagnosis of heartwater disease by indirect immunofluorescence. Rev Elev Med Vet Pays Trop 1990; 43: 159-166.
16. Martinez D, Perez JM, Sheikboudou C, Debus A & Bensaid A. Comparative efficacy of Freund's and Montanide ISA 50 adjuvants for the immunisation of goats against heartwater with inactivated Cowdria ruminantium. Vet Parasitol 1996; 67: 175-184.
17. Matheron G, Barre N, Camus E & Gogue J. Genetic resistance of Guadeloupe native goats to heartwater. Onderstepoort J Vet Res 1987; 54: 337-340.
18. + T cell frequencies by flow cytometry: evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency. J Clin Invest 1997; 99: 1739-1750.
19. Weynants V, Walravens K, Didembourg C, Flanagan P, Godfroid J & Letesson JJ. Quantitative assessment by flow cytometry of T-lymphocytes producing antigen-specific gamma-interferon in Brucella immune cattle. Vet Immunol Immunopathol 1998; 66: 309-320.
20. Bensaid A & Hadam M. Individual antigens of cattle. Bovine CD4 (BoCD4). Vet Immunol Immunopathol 1991; 27: 51-44.
21. Maddox JF, Mackay CR & Brandon MR. Surface antigens, SBU-T4 and SBU-T8, of sheep T lymphocyte subsets defined by monoclonal antibodies. Immunology 1985; 55: 739-748.
22. - T lymphocytes (WC1, WC2). Vet Immunol Immunopathol 1991; 27: 71-76.
23. Weynants V, Gilson D, Furger A. et al. Production and characterisation of monoclonal antibodies specific for bovine interleukin-4. Vet Immunol Immunopathol 1998; 66: 99-112.
24. Walravens K, Wellemans V, Weynants V, et al. Analysis of the antigen-specific IFN-gamma producing T-cell subsets in cattle experimentally infected with Mycobacterium bovis. Vet Immunol Immunopathol 2002; 84: 29-41.
25. + T-cells lines reactive with soluble and membrane antigens of Cowdria ruminantium. Vet Immunol Immunopathol 1999; 70: 269-276.
26. Rolph MS & Kaufmann SH. CD40 signaling converts a minimally immunogenic antigen into a potent vaccine against the intracellular pathogen Listeria monocytogenes. J Immunol 2001; 166: 5115-5121.
27. Aucouturier J, Dupuis L, Deville S, Ascarateil S & Ganne V. Montanide ISA 720 and 51: a new generation of water in oil emulsions as adjuvants for human vaccines. Expert Rev Vaccines 2002; 1: 111-118.
28. Martinez D 1997: Analysis of the immune response of ruminants to Cowdria ruminantium infection. Development of an inactivated vaccine. PhD Thesis. Utrecht, The Netherlands, University of Utrecht.
29. Sallusto F, Lenig D, Forster R, Lipp M & Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999; 401: 708-712.
30. Gale KR, Gartside MG, Dimmock CM, Zakrzewski H & Leatch G. Peripheral blood lymphocyte proliferative responses in cattle infected with or vaccinated against Anaplasma marginale. Parasitol Res 1996; 82: 551-562.
31. Du Plessis JL. Pathogenesis of heartwater. I. Cowdria ruminantium in the lymph nodes of domestic ruminants. Onderstepoort J Vet Res 1970; 37: 89-95.
32. Stoolman LM. Adhesion molecules controlling lymphocyte migration. Cell 1989; 56: 907-910.
33. Van Kleef M, Gunter NJ, Macmillan H, Allsopp BA, Shkap V & Brown WC. Identification of Cowdria ruminantium antigens that stimulate proliferation of lymphocytes from cattle immunised by infection and treatment or with inactivated organisms. Infect Immun 2000; 68: 603-614.
34. Naiman BM, Blumerman S, Alt D, et al. Evaluation of type 1 immune response in naive and vaccinated animals following challenge with Leptospira borgpetersenii serovar Hardjo: involvement of WCl (+) gammadelta and CD4 T cells. Infect Immun 2002; 70: 6147-6157.
35. Hope JC, Sopp P & Howard CJ. NK-like CD8 (+) cells in immunologically naive neonatal calves that respond to dendritic cells infected with Mycobacterium bovis BCG. J Leukoc Biol 2002; 71: 184-194.
36. Mahan SM, Sileghem M, Smith GE & Byrom B. Neutralization of bovine concanavalin-A T cell supernatant-mediated anti-Cowdria ruminantium activity with antibodies specific to interferon gamma but not to tumour necrosis factor. Parasite Immunol 1996; 18: 317-324.
37. Totté P, Vachiery N, Martinez D, et al. Recombinant bovine interferon gamma inhibits the growth of Cowdria ruminantium but fails to induce major histocompatibility complex class II following infection of endothelial cells. Vet Immunol Immunopathol 1996; 53: 61-71.