Potent antiulcerogenic activity of methanol extract of Cissus quadrangularis by antioxidative mechanism

Journal of Clinical Biochemistry and Nutrition

Volumn 34, Issue 2, 2004, Pages 43-47

  Jainu, Mallika ^a   Devi, C S Shyamala ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Antioxidant status; Aspirin; Cissus quadrangularis; Gastric mucosal lesion

Indexed keywords

ACETYLSALICYLIC ACID; ALKALINE PHOSPHATASE; ANTIULCER AGENT; CISSUS QUADRANGULARIS EXTRACT; HERBACEOUS AGENT; LIPID PEROXIDE; METHANOL; MYELOPEROXIDASE; NONSTEROID ANTIINFLAMMATORY AGENT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CISSUS; CISSUS QUADRANGULARIS; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; ENZYME ASSAY; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; MEDICINAL PLANT; NONHUMAN; OXIDATIVE STRESS; QUANTITATIVE ANALYSIS; RAT; STOMACH MUCOSA; STOMACH MUCOSA LESION; STOMACH MUCUS; STOMACH PROTECTION; STOMACH ULCER; TISSUE LEVEL; ULCER HEALING;

ANIMALIA; CISSUS; CISSUS QUADRANGULARIS;

EID: 3142615389     PISSN: 09120009     EISSN: None     Source Type: Journal    
DOI: 10.3164/jcbn.34.43     Document Type: Article

References (35)

1. Aruoma, O.I. and Guppet, S.L.: Antioxidant Methodology in vivo and in vitro Concepts, AOCS Press, Champaign, IL, pp. 41-172, 1997.
2. Phian, G., Regillo, C., and Szabo, S.: Free radical and lipid peroxidation in ethanol or aspirin induced gastric mucosal injury. Dig. Dis. Sci., 32, 1395-1401, 1987.
3. Shukla Mukherjee Sur, A. and Maiti, B.R.: Hepato-protective effect of Swertia chirata on rat. Indian J. Exp. Biol., 35, 384-388, 1997.
4. Prakash, A. and Faulds, D.: Rebaprazole. Drugs, 2, 55-56, 1998.
5. Akthar, H.H. and Ahmed, K.U.: Antiulcerogenic evaluation of the methanolic extract of some indegenous medicinal plants of Pakistan in aspirin ulcerated rats. J. Ethnopharmacol., 46, 1-6, 1998.
6. Kritikar, K.R. and Basu, B.D.: Indian Medicinal Plants (Third Revised and Enlarged ed.), ed. by Basu, L.M., Allahabad, Vol. 3, pp. 841-843, 2000.
7. Anoop, A. and Jagdeesan, M.: Gastric and duodenal antiulcer and cytoprotective effect of Cissus quadrangularis Linn. variant II in rat. Nig. J. Nat. Prod. Med., 6, 1-7, 2002.
8. Deka, D.K., Lahon, L.C., Saikia, J., and Mukit, A.: Effect of Cissus quadrangularis in acceleration healing process of experimentally fractured radius-ulna of dog; A experimental study. Indian J. Pharmacol., 26, 44-45, 1994.
9. Singh, S.P., Misra, N., Dixit, K.S., Singh, N., and Kohli, R.P.: An experimental study of analgesic activity of Cissus quadrangularis. Indian J. Pharmacol., 2, 162-263, 1984.
10. Biswajit, M., Ray Chaudhuri, S.G., Arun, R., and Sandip Bandyopadhyay, K.: Effect of ethanol extract of Piper betle Linn. leaf on healing of NSAID-induced experimental ulcer - A novel role of free radical scavenging action. Indian J. Exp. Biol., 41, 311-315, 2003.
11. Sata, N., Kawano, S., Tsuji, S., and Kamada, T.: Microvascular basis of gastric mucosal protection. J. Clin. Gastroenterol., 10, S13-S18, 1988.
12. Szabo, S., Trier, J.S., and Brown, A.: A quantitative method for assessing the extent of experimental gastric erosions and ulcer. J. Pharmacol. Methods, 13, 59-66, 1985.
13. Martin, M.J., Marhuenda, E., and Alarcon, L.: Esculine, ranitidine and carbenoxolone different modes of action on gastric mucosa. Gen. Pharmacol., 22, 1001-1004, 1991.
14. Lowry, O.H., Rosebrough, N.J., and Fars, A.L.: Protein measurement with folin phenol reagent. J. Biol. Chem., 193, 265-278, 1951.
15. Kind, P.R.N. and King, E.J.: Determination of serum alkaline phosphatase. Clin. Pathol., 7, 322-326, 1954.
16. Suzuki, K., Sasagawa, S., Sakatani, T., and Fujikura, T.: Assay method for myeloperoxidase in human polymorphonuclear leukocytes. Anal. Biochem., 132, 345-353, 1983.
17. Ohkawa, H., Ohishi, N., and Yagi, K.: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95, 351-358, 1979.
18. Misra, H.P. and Fridovich, I.: The role of superoxide anion in the autooxidation of epinephine and a simple assay for SOD. J. Biol. Chem., 247, 3170-3175, 1972.
19. Luck, H.: Catalase, in Methods of Enzymatic Analysis, ed. by Bergmeyer, H.U., Academic Press, New York, London, pp. 885-888, 1963.
20. Beautler, E. and Kelley, B.M.: The effect of sodium nitrate on red cell glutathione. Experientia, 19, 96-97, 1963.
21. Paglia, D.E. and Valentaina, W.N.: Studies on the GSH and Glutathione characterization of erythrocyte GPX. J. Lab. Clin. Med., 70, 158-169, 1967.
22. Habig, W.H., Pabst, M.J., and Jakoby, W.B.: Glutathione-S-transferase. The first enzymatic step in mercapturic acid formation. J. Biol. Chem., 240, 71130-71139, 1974.
23. Pillai, K.S. and Pillai, C.: Anfioxidant in health. Indian J. Physiol. Pharmacol., 46, 1-5, 2002.
24. Steinmeyer, J.: Pharmacological basis for the therapy of pain and inflammation with NSAIDs. Arthritis Res., 2, 379-385, 2000.
25. Martin, M.J., Alarcon de la Lastra, C., and Motilva, V.: Bases fisiopatologicas farmacologicas de la ulcera peptica, Secretariado de publications, Universidad de Sevilla Press, Sevilla, pp. 25-30, 1993.
26. Obi, E., Meh, J.K., Orisakwe, O.E., Afonne, O.J., Ilondu, N.A., and Agbasi, P.U.: Investigation of the biochemical evidence for the antiulcerogenic activity of Synclisia scarbrida. Indian J. Pharmacol., 32, 381-383, 2000.
27. Krawisz, J.F., Sharan, P., and Stenson, W.F.: Quantitative assay for acute intestinal inflammation based on MPO activity. Assessment of inflammation in rat and hamster models. Gastroenterology, 87, 1344-1350, 1984.
28. Yoshida, N., Takemura, T., Granger, D.N., Anderson, D.C., Wolf, R.E., McIntive, L.V., and Kvietys, P.R.: Molecular determinations of aspirin-induced neutrophil adherence to endothelial cells. Gastroenterology, 105, 715-724, 1993.
29. Zimmerman, J.J., Ceisielski, W., and Lewandoski, J.: Neutrophil-mediated phospholipid peroxidation assessed chromatography-mass spectroscopy. Am. J. Physiol., 273, C653-661, 1997.
30. Naito, T., Takagi, T., Matsuyama, K., Yoshida, N., and Yoshikawa, T.: Pioglitazone, a specific PPAR-γ ligand inhibits aspirin-induced gastric mucosal injury in rats. Aliment. Pharmacol. Ther., 15, 865-873, 2001.
31. Body, S.C., Samasa, H.A., and Body, M.R.: Gastric glutathione depletion and acute ulcerogenesis by diethylamaleate given subcutaneously in rats. Life Sci., 28, 2987-2992, 1981.
32. Mahendran, P. and Shyamala Devi, C.S.: The modulating effect of Garcinia combogia extracts on ethanol induced peroxidative damage in rats. Indian J. Pharmacol., 33, 87-91, 2001.
33. Daneses, S., Candelli, M., Cremonini, F., and Stevens, T.R.: High oxygen free radicals generation in gastric mucosa infected by H. pylori cytotoxic strains (abstract). Gastroenterology, 118, A739-A743.
34. Madan, M.G. and Ram, K.V.: Unsymmetric tetracyclic triterpenoid from Cissus quadrangularis. Phytochemistry, 29, 336-337, 1990.
35. Udupa, K.N., Prasad, G., and Sen, S.P.: The effect of phytogenic anabolic steroid in the acceleration of fracture repair. Life Sci., 4, 317-327, 1965.