New broad-spectrum parenteral cephalosporins exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Part 3: 7β-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2- ethoxyiminoacetamido] cephalosporins bearing 4-[3-(aminoalkyl)-ureido]-1- pyridinium at C-3′

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 15, 2004, Pages 4221-4231

  Yoshizawa, Hidenori ^a   Kubota, Tadatoshi ^a   Itani, Hikaru ^a   Minami, Kyoji ^a   Miwa, Hideaki ^a   Nishitani, Yasuhiro ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

(2 PYRIDIN 4 YLETHYL)CARBAMIC ACID TERT BUTYL ESTER; (2 TERT BUTOXYCARBONYLAMINOETHYL)PYRIDIN 4 YLCARBAMIC ACID TERT BUTYL ESTER; (3 TERT BUTOXYCARBONYLAMINOPROPYL)PYRIDIN 4 YLCARBAMIC ACID TERT BUTYL ESTER; 1 [2 (1,3 DIOXO 1,3 DIHYDROISOINDOL 2 YL)ETHYL] 3 PYRIDIN 4 YLUREA; 1 [2 N,N' BIS(TERT BUTOXYCARBONYL)GUANIDINOETHYL] 3 PYRIDIN 4 YLUREA; 1 [3 N,N' BIS(TERT BUTOXYCARBONYL)GUANIDINOPROPYL] 3 PYRIDIN 4 YLUREA; 3 (3 PYRIDIN 4 YLUREIDO)PYRROLIDINE 1 CARBOXYLIC ACID TERT BUTYL ESTER; 4 [2 (3 PYRIDIN 4 YLUREIDO)ETHYL]IMIDAZOLE 1 CARBOXYLIC ACID TERT BUTYL ESTER; 4 [3 (AMINO)UREIDO] 1 PYRIDINIUM; 7 [2 (5 AMINO 1,2,4 THIADIAZOL 3 YL) 2 ETHOXYIMINOACETAMIDO] 3 [4 [3 (2 AMINOETHYL)UREIDO]PYRIDINIUM 1 YL]METHYL 3 CEPHEM 4 CARBOXYLATE; 7BETA [2 (5 AMINO 1,2,4 THIADIAZOL 3 YL) 2 ETHOXYIMINOACETAMIDO]CEPHALOSPORIN; [1 (PYRIDIN 3 YLCARBAMOYL)ETHYL]CARBAMIC ACID TERT BUTYL ESTER; [1 (PYRIDIN 4 YLCARBAMOYL)ETHYL]CARBAMIC ACID TERT BUTYL ESTER; [1 METHYL 2 (3 PYRIDIN 4 YLUREIDO)ETHYL]CARBAMIC ACID TERT BUTYL ESTER; [2 (3 PYRIDIN 4 YLUREIDO)ETHYL]CARBAMIC ACID TERT BUTYL ESTER; [2 (PYRIDIN 4 YLCARBAMOYL)ETHYL]CARBAMIC ACID TERT BUTYL ESTER; [2 (PYRIDIN 4 YLOXY)ETHYL]CARBAMIC ACID TERT BUTYL ESTER; [2 [(PYRIDINE 3 CARBONYL)AMINO]ETHYL]CARBAMIC ACID TERT BUTYL ESTER; [2 [(PYRIDINE 4 CARBONYL)AMINO]ETHYL]CARBAMIC ACID TERT BUTYL ESTER; [3 (3 PYRIDIN 4 YLUREIDO) 2 TRIETHYLSILANYLOXYPROPYL]CARBAMIC ACID TERT BUTYL ESTER; [3 (3 PYRIDIN 4 YLUREIDO)PROPYL]CARBAMIC ACID TERT BUTYL ESTER; CEPHALOSPORIN DERIVATIVE; METHYL[3 (3 PYRIDIN 4 YLUREIDO)PROPYL]CARBAMIC ACID TERT BUTYL ESTER; PYRIDIN 4 YLCARBAMIC ACID 2 TERT BUTOXYCARBONYLAMINOETHYL ESTER; PYRIDINIUM DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PSEUDOMONAS AERUGINOSA; STRUCTURE ANALYSIS;

ANTI-BACTERIAL AGENTS; CEPHALOSPORINS; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PSEUDOMONAS AERUGINOSA; PYRIDINIUM COMPOUNDS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 3142592640     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.05.021     Document Type: Article

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