Dense pellicular agarose-glass beads for expanded bed application: Flow hydrodynamics and solid phase classifications

Chinese Journal of Chemical Engineering

Volumn 12, Issue 2, 2004, Pages 310-314

  Zhou, Xin ^a   Shi, Qinghong ^a   Bai, Shu ^a   Sun, Yan ^a  

^a TIANJIN UNIVERSITY   (China)

Author keywords

Dense pellicular medium; Density distribution; Expanded bed; Size distribution; Solid phase classification

Indexed keywords

ADSORPTION; DENSITY (SPECIFIC GRAVITY); PARTICLE SIZE ANALYSIS; SUSPENSIONS (FLUIDS);

DENSE PELLICULAR AGAROSE GLASS MATRICES; DENSE PELLICULAR MEDIUM; DENSITY DISTRIBUTION; EXPANDED BED; SIZE DISTRIBUTION; SOLID PHASE CLASSIFICATION;

HYDRODYNAMICS;

FLUID FLOW; GLASS BEAD; HYDRODYNAMICS; PARTICLE SIZE; SIZE DISTRIBUTION;

EID: 3142570902     PISSN: 10049541     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Hjorth, R., Expanded-bed adsorption in industrial bioprocessing: Recent developments, Trends Biotechnol., 15, 230-235 (1997).
2. Lei, Y., Lin, D., Yao, S.J., Liu, Z.Z., Zhu, Z.Q., Physical and hydrodynamic properties of spherical cellulose-titanium dioxide composite matrix for expanded bed adsorption, Chinese J. Chem. Eng., 11, 141-145 (2003).
3. Hjorth, R., Kampe, S., Carlsson, M., Analysis of some operating parameters of novel adsorbents for recovery of proteins in expanded beds, Bioseparation, 5, 217-223 (1995).
4. Tong, X.D., Sun, Y., Nd-Fe-B alloy-densified agarose gel for expanded bed adsorption of proteins, J. Chromatogr. A., 943, 63-75 (2002).
5. Ghose, S., Chase, H.A., Expanded bed chromatography of protein in small diameter column. II. Methods development and scale up, Bioseparation, 9, 29-36 (2000).
6. Bruce, L.J., Chase, H.A., Evaluation of the effect of in-bed sampling on expanded bed adsorption, Bioseparation, 8, 77-83 (1999).
7. Ghose, S., Chase, H.A., Titchener-Hooker, N., Bed height monitoring and control for expanded bed chromatography, Bioprocess Eng., 23, 701-708 (2000).
8. Karau, A., Benken, C., Thommes, J., Kula, M.R., The influence of particle size distribution and operating condition on the adsorption performance in fluidized beds, Biotechnol. Bioeng., 55, 54-64 (1997).
9. Willoughby, N.A., Hjorth, R., Hooker, N.T., Experimental measurement of particle size distribution and voidage in an expanded bed adsorption system, Biotechnol. Bioeng., 69, 648-653 (2000).
10. Bruce, L.J., Chase, H.A., Hydrodynamics and adsorption behavior within an expanded bed adsorption column studied using in-bed sampling, Chem. Eng. Sci., 56, 3149-3162 (2001).
11. Tong, X.D., Sun, Y., Particle size and density distributions of two dense matrices in expanded bed system, J. Chromatogr. A, 977, 173-183 (2002).
12. Tong, X.D., Sun, Y., Modeling of expanded-bed protein adsorption by taking into account the axial particle size distribution, Biochem. Eng. J., 16, 265-272 (2003).
13. Zhou, X., Shi, Q.H., Bai, S., Sun, Y. Dense pellicular agarose-glass beads for expanded bed application: Fabrication and characterization for effective protein adsorption, Biochem. Eng. J., 18, 81-88 (2004).
14. Barnfield Frej, A.K., Johnsson, H.J., Johnsson, S., Leijon, P., Expanded bed adsorption at production scale: Scale-up verification, process example and sanitization of column and adsorbent, Bioprocess Eng., 16, 57-63 (1997).
15. Chang, Y.K., Chase, H.A., Development of operating conditions for protein purification using expanded bed techniques: The effect of the degree of bed expansion on adsorption performance, Biotechnol. Bioeng., 49, 512-526 (1996).
16. Xue, B., Tong, X.D., Sun, Y., Polydisperse model for the hydrodynamics of expanded-bed adsorption systems, AIChE J., 49, 2510-2518 (2003).