Spt3 and Mot1 cooperate in nucleosome remodeling independently of TBP recruitment

EMBO Journal

Volumn 23, Issue 9, 2004, Pages 1943-1948

  Topalidou, Irini ^a   Papamichos Chronakis, Manolis ^a   Thireos, George ^a,c   Tzamarias, Dimitris ^a,b  

^a INSTITUTE OF COMPUTER SCIENCE   (Greece)

^b HELLENIC OPEN UNIVERSITY   (Greece)

^c INSTITUTE OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY   (Greece)

Author keywords

GAL1; Mot1; Nucleosome remodeling; SAGA; Spt3

Indexed keywords

ADAPTOR PROTEIN; ADENOSINE TRIPHOSPHATASE; HISTONE ACETYLTRANSFERASE GCN5; MOT1 PROTEIN; PROTEIN; SNF2 PROTEIN; SPT3 PROTEIN; TATA BINDING PROTEIN; TRANSCRIPTION FACTOR GAL4; TRANSCRIPTION FACTOR SAGA; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN STRUCTURE; GAL1 GENE; GENE; GENE INDUCTION; GENE INTERACTION; GENETIC TRANSCRIPTION; NONHUMAN; NUCLEOSOME; NUCLEOSOME REMODELING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN TRANSPORT; TRANSACTIVATION; YEAST;

CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN IMMUNOPRECIPITATION; DNA HELICASES; DNA-BINDING PROTEINS; GENE EXPRESSION; HISTONE ACETYLTRANSFERASES; NUCLEOSOMES; PLASMIDS; PROMOTER REGIONS (GENETICS); PROTEIN KINASES; SACCHAROMYCES CEREVISIAE PROTEINS; TATA-BINDING PROTEIN ASSOCIATED FACTORS; TRANSCRIPTION FACTORS; YEASTS;

EID: 3142552259     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600199     Document Type: Article

References (37)

1. Andrau JC, Van Oevelen CJ, Van Teeffelen HA, Weil PA, Holstege FC, Timmers HT (2002) Mot1p is essential for TBP recruitment to selected promoters during in vivo gene activation. EMBO J 21: 5173-5183
2. Auble DT, Hansen KE, Mueller CG, Lane WS, Thorner J, Hahn S (1994) Mot1, a global repressor of RNA polymerase II transcription, inhibits TBP binding to DNA by an ATP-dependent mechanism. Genes Dev 8: 1920-1934
3. Auble DT, Wang D, Post KW, Hahn S (1997) Molecular analysis of the SNF2/SWI2 protein family member MOT1, an ATP-driven enzyme that dissociates TATA-binding protein from DNA. Mol Cell Biol 17: 4842-4851
4. Axelrod JD, Reagan MS, Majors J (1993) GAL4 disrupts a repressing nucleosome during activation of GAL1 transcription in vivo. Genes Dev 7: 857-869
5. Balasubramanian R, Pray-Grant MG, Selleck W, Grant PA, Tan S (2002) Role of the Ada2 and Ada3 transcriptional coactivators in histone acetylation. J Biol Chem 277: 7989-7995
6. Barbaric S, Reinke H, Horz W (2003) Multiple mechanistically distinct functions of SAGA at the PHO5 promoter. Mol Cell Biol 23: 3468-3476
7. Bhaumik SR, Green MR (2001) SAGA is an essential in vivo target of the yeast acidic activator Gal4p. Genes Dev 15: 1935-1945
8. Bhaumik SR, Green MR (2002) Differential requirement of SAGA components for recruitment of TATA-box-binding protein to promoters in vivo. Mol Cell Biol 22: 7365-7371
9. Boeger H, Griesenbeck J, Strattan JS, Kornberg RD (2003) Nucleosomes unfold completely at a transcriptionally active promoter. Mol Cell 11: 1587-1598
10. Brown CE, Howe L, Sousa K, Alley SC, Carrozza MJ, Tan S, Workman JL (2001) Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit. Science 292: 2333-2337
11. Collart MA (1996) The NOT, SPT3, and MOT1 genes functionally interact to regulate transcription at core promoters. Mol Cell Biol 16: 6668-6676
12. Dasgupta A, Darst RP, Martin KJ, Afshari CA, Auble DT (2002) Mot1 activates and represses transcription by direct, ATPase-dependent mechanisms. Proc Natl Acad Sci USA 99: 2666-2671
13. Dudley AM, Rougeulle C, Winston F (1999) The Spt components of SAGA facilitate TBP binding to a promoter at a post-activator-binding step in vivo. Genes Dev 13: 2940-2945
14. Eisenmann DM, Arndt KM, Ricupero SL, Rooney JW, Winston F (1992) SPT3 interacts with TFIID to allow normal transcription in Saccharomyces cerevisiae. Genes Dev 6: 1319-1331
15. Eisenmann DM, Chapon C, Roberts SM, Dollard C, Winston F (1994) The Saccharomyces cerevisiae SPT8 gene encodes a very acidic protein that is functionally related to SPT3 and TATA-binding protein. Genetics 137: 647-657
16. Geisberg JV, Moqtaderi Z, Kuras L, Struhl K (2002) Mot1 associates with transcriptionally active promoters and inhibits association of NC2 in Saccharomyces cerevisiae. Mol Cell Biol 22: 8122-8134
17. Georgakopoulos T, Gounalaki N, Thireos G (1995) Genetic evidence for the interaction of the yeast transcriptional co-activator proteins GCN5 and ADA2. Mol Gen Genet 246: 723-728
18. Grant PA, Schieltz D, Pray-Grant MG, Steger DJ, Reese JC, Yates III JR, Workman JL (1998) A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation. Cell 94: 45-53
19. Johnston M, Flick JS, Pexton T (1994) Multiple mechanisms provide rapid and stringent glucose repression of GAL gene expression in Saccharomyces cerevisiae. Mol Cell Biol 14: 3834-3841
20. Larschan E, Winston F (2001) The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4. Genes Dev 15: 1946-1956
21. Lee TI, Causton HC, Holstege FC, Shen WC, Hannett N, Jennings EG, Winston F, Green MR, Young RA (2000) Redundant roles for the TFIID and SAGA complexes in global transcription. Nature 405: 701-704
22. Lee TI, Young RA (1998) Regulation of gene expression by TBP-associated proteins. Genes Dev 12: 1398-1408
23. Lohr D (1997) Nucleosome transactions on the promoters of the yeast GAL and PHO genes. J Biol Chem 272: 26795-26798
24. Madison JM, Winston F (1997) Evidence that Spt3 functionally interacts with Mot1, TFIIA, and TATA-binding protein to confer promoter-specific transcriptional control in Saccharomyces cerevisiae. Mol Cell Biol 17: 287-295
25. Papamichos-Chronakis M, Petrakis T, Ktistaki E, Topalidou I, Tzamarias D (2002) Cti6, a PHD domain protein, bridges the Cyc8-Tup1 corepressor and the SAGA coactivator to overcome repression at GAL1. Mol Cell 9: 1297-1305
26. Prelich G (1997) Saccharomyces cerevisiae BUR6 encodes a DRAP1/ NC2alpha homolog that has both positive and negative roles in transcription in vivo. Mol Cell Biol 17: 2057-2065
27. Reinke H, Horz W (2003) Histones are first hyperacetylated and then lose contact with the activated PHO5 promoter. Mol Cell 11: 1599-1607
28. Roth SY, Denu JM, Allis CD (2001) Histone acetyltransferases. Annu Rev Biochem 70: 81-120
29. Selleck W, Howley R, Fang Q, Podolny V, Fried MG, Buratowski S, Tan S (2001) A histone fold TAF octamer within the yeast TFIID transcriptional coactivator. Nat Struct Biol 8: 695-700
30. Sterner DE, Grant PA, Roberts SM, Duggan LJ, Belotserkovskaya R, Pacella LA, Winston F, Workman JL, Berger SL (1999) Functional organization of the yeast SAGA complex: distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction. Mol Cell Biol 19: 86-98
31. Sterner DE, Wang X, Bloom MH, Simon GM, Berger SL (2002) The SANT domain of Ada2 is required for normal acetylation of histones by the yeast SAGA complex. J Biol Chem 277: 8178-8186
32. Syntichaki P, Topalidou I, Thireos G (2000) The Gcn5 bromodomain co-ordinates nucleosome remodelling. Nature 404: 414-417
33. Thireos G, Penn MD, Greer H (1984) 5′ untranslated sequences are required for the translational control of a yeast regulatory gene. Proc Natl Acad Sci USA 81: 5096-5100
34. Topalidou I, Papamichos-Chronakis M, Thireos G (2003) Post-TATA binding protein recruitment clearance of Gcn5-dependent histone acetylation within promoter nucleosomes. Mol Cell Biol 23: 7809-7817
35. Topalidou I, Thireos G (2003) Gcn4 occupancy of open reading frame regions results in the recruitment of chromatin-modifying complexes but not the mediator complex. EMBO Rep 4: 872-876
36. Winston F, Durbin KJ, Fink GR (1984) The SPT3 gene is required for normal transcription of Ty elements in S. cerevisiae. Cell 39: 675-682
37. Yamaguchi Y, Narita T, Inukai N, Wada T, Handa H (2001) SPT genes: key players in the regulation of transcription, chromatin structure and other cellular processes. J Biochem (Tokyo) 129: 185-191