Effect of landomycin E on expression of mRNA coding for transforming growth factor β ligands and specific receptors in MCF-7 cells

Experimental Oncology

Volumn 27, Issue 4, 2005, Pages 330-332

  Panchuk, R ^a,b   Korynevska, A ^a   Stoika, R ^a,b  

^a INSTITUTE OF CELL BIOLOGY   (Ukraine)

^b IVAN FRANKO NATIONAL UNIVERSITY OF LVIV   (Ukraine)

Author keywords

Human breast adenocarcinoma; Landomycin E; RT PCR; TGF

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; COMPLEMENTARY DNA; DOXORUBICIN; LANDOMYCIN E; LIGAND; MESSENGER RNA; OLEANDOMYCIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL CULTURE; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENOCARCINOMA; AMINOGLYCOSIDES; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; DOXORUBICIN; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FEMALE; GENE EXPRESSION; HUMANS; LIGANDS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA;

EID: 31344475316     PISSN: 18129269     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Bartram U, Speer C. The role of transforming growth factor β in lung development and disease. CHEST 2004; 125: 754-65.
2. Blobe G, Schiemann W, Lodish H. Role of transforming growth factor-β in human disease. New Engl J Med 2000; 342: 1350-8.
3. 1/S cell cycle progression and induces apoptosis. Bioorg Med Chem Lett 1999; 9: 1663-6.
4. Derynck R, Zhang Y. Smad-dependent and Smad-independent pathways in TGF-β family signaling. Nature 2003; 425: 577-84.
5. Henkel T, Rohr J, Beale J, Schwenen L. Landonycines, new angucycline antibiotics from Streptomyces sp. J Antibiot 1990; XLIII: 492-503.
6. Korynevska AV, Matselyukh BP, Stoika RS. In vitro study of landomycin E antitumor activity. Exp Oncol 2003; 25: 98-105.
7. Krohn K, Rohr J. Angucyclines: total synthesis, new structures and biosynthetic studies of an emerging new class of antibiotics. Topics Curr Chem 1997; 188: 127-95.
8. Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, Fan RS, Zborowska E, Kinzler KW, Vogelstein B. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science 1995; 268: 1336-8.
9. Massague J, Blain S, Lo R. TGF-β signaling in growth control, cancer, and heritable disorders. Cell 2000; 103: 295-309.
10. Massague J. TGF-β signal transduction. Ann Rev Biochem 1998; 67: 753-91.
11. Matselyukh B, Lavrinchuk VYa. Generation and characteristics of Streptomyces globisporus 1912 mutants, defective in biosynthesis of landomycin E. Microbiol Zhurn 1999; 61: 22-7 (In Ukrainian).
12. Panchuk RR, Korynevska AV, Osyp YuL, Ostash BO, Fedorenko VO, Stoika RS. Study of mechanisms of landomycin E action on mammalian cells. Visnyk Lviv Univ 2004; 35: 54-9 (In Ukrainian).
13. Polishchuk LV, Ganusevych II, Matseluykh BP. Investigation of antitumor actions of antibiotics, produced by Streptomyces globisporus 1912, on Guerin model of carcinoma in rats. Microbiol Zhum 1996; 58: 55-8 (In Ukrainian).
14. Rohr J, Thiericke R. Angucycline group antibiotics. Nat Prod Rep 1992; 9: 103-37.
15. Rohr J, Wohlert S-E, Oelkers C, Kirschning A, Ries M. Biosynthetic short activation of the 2,3,6-trideoxysugar L-rhodinose. Chem Commun 1997; 10: 973-97
16. Souchelnytskyi S. Transforming growth factor-β signaling and its role in cancer. Exp Oncol 2002; 24: 3-12.
17. Stoika R, Yakymovych M, Souchelnytskyi S, Yakymovych I. Potential role of transforming growth factor beta 1 in drug resistance of tumor cells. Acta Biochim Pol 2003; 50: 497-508.
18. Villanueva A, Garcia C, Paules AB, Vicente M, Megias M, Reyes G, de Villalonga P, Agell N, Lluis F, Bachs O, Capella G. Disruption of the antiproliferative TGF-β signaling pathways in human pancreatic cancer cells. Oncogene 1998; 17: 1969-78.