L-arginine supplementation enhances exhaled NO, breath condensate VEGF, and headache at 4342 m

High Altitude Medicine and Biology

Volumn 6, Issue 4, 2005, Pages 289-300

  Mansoor, Jim K ^a   Morrissey, Brian M ^b   Walby, William F ^b   Yoneda, Ken Y ^b,c   Juarez, Maya ^b   Kajekar, Radhika ^b   Severinghaus, John W ^d   Eldridge, Marlowe W ^e   Schelegle, Edward S ^b  

^a UNIVERSITY OF THE PACIFIC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VA NORTHERN CALIFORNIA HEALTH CARE SYSTEM   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Altitude; EPO; HIF 1; Hypoxia; Lake Louise scores

Indexed keywords

ARGININE; ERYTHROPOIETIN; HEMOGLOBIN; HYPOXIA INDUCIBLE FACTOR 1; NITRIC OXIDE; PLACEBO; VASCULOTROPIN;

ADULT; ALTITUDE DISEASE; ARTICLE; BLOOD SAMPLING; BREATH ANALYSIS; CHEMOLUMINESCENCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG RESPONSE; EXPIRATORY FLOW RATE; HEADACHE; HEART RATE; HEMOGLOBIN DETERMINATION; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SCORING SYSTEM; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ADULT; ALTITUDE SICKNESS; ANALYSIS OF VARIANCE; ARGININE; BREATH TESTS; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; HEADACHE; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 31344470434     PISSN: 15270297     EISSN: None     Source Type: Journal    
DOI: 10.1089/ham.2005.6.289     Document Type: Article

References (31)

1. Alderton W., Cooper C., and Knowles R. (2001). Nitric oxide synthases: structure, function and inhibition. Biochem. J. 357:593-615.
2. American Thoracic Society. (1999). Recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide in adults and children - 1999. Am. J. Respir. Crit. Care Med. 160:2104-2117.
3. Ausserer H., Neupane P., Waanders R., Ascher R., Bitzer O., Pfefferkorn T., and Feddersen B. (2004). Acute mountain sickness is preceded by early impairment of cerebral autoregulation. High Alt. Med. Biol. 5:202 (abstract).
4. Bartsch P., Bailey D., Berger M., Knauth M., and Baumgartner R. (2004). Acute mounatin sickness: controversies and advances. High Alt. Med. Biol. 5:110-124.
5. Baumgartner R., Spyridopoulos I., Bartsch, P., Maggiorini, M., and Oelz, O. (1999). Acute mountain sickness is not related to cerebral blood flow. A decompression chamber study. J. Appl. Physiol. 86:1578-1582.
6. Braman R., and Hendrix S. (1989). Nanogram nitrite and nitrate determination in environmental and biological materials by vanadium (III) reduction with chemiluminescence detection. Anal. Chem. 61:2715-2718.
7. Corradi M., Pesci A., Casana R., Alinovi R., Goldoni M., Vittoria Vettori M., and Cuomo A. (2003). Nitrate in exhaled breath condensate of patients with different airway diseases. Nitric Oxide Bio. Chem. 8:26-30.
8. Eckardt K.U., Boutellier U., Kurtz A., Schopen M., Koller E.A., and Bauer C. (1989). Rate of erythropoietin formation in humans in response to acute hypobaric hypoxia. J. Appl. Physiol. 66:1785-1788.
9. Effros R., Hoagland K., Bosbous M., Castillo D., Foss B., Dunning M., Gare M., Lin W., and Sun F. (2002). Dilution of respiratory solutes in exhaled condensates. Am. J. Respir. Crit. Care Med. 165:663-669.
10. Fischer S., Clauss M., Wiesnet M., Renz D., Schaper W., and Karliczek G. (1999). Hypoxia induces permeability in brain microvessel endothelial cells via VEGF and NO. Am. J. Physiol. 276:C812-C820.
11. Honigman B., Theis M., Koziol-McLain J., Roach R., Yip R., Houston C., and Moore L. (1993). Acute mountain sickness in a general tourist population at moderate altitudes. Ann. Intern. Med. 118:587-592.
12. Kaner R., and Crystal R. (2004). Pathogenesis of high altitude pulmonary edema: does alveolar epithelial lining fluid vascular endothelial growth factor exacerbate capillary leak? High Alt. Med. Biol. 5(4):399-408.
13. Kharitonov S., Lubec G., Lubec B., Hjelm M., and Barnes P. (1995). L-arginine increases exhaled nitric oxide in normal human subjects. Clin. Sci. (Lond). 88: 135-139.
14. Kimura H., Ogura T., Kurashima Y., Weisz A., and Esumi H. (2002). Effects of nitric oxide donors on vascular endothelial growth factor gene induction. Biochem. Biophys. Res. Comm. 296:976-982.
15. Lee J., Bae S., Jeong J., Kim S., and Kim K. (2004). Hypoxia-inducible factor (HIF-1)α: its protein stability and biological functions. Experiments Mol. Med. 36:1-12.
16. Milledge J., and Cotes P. (1985). Serum erythropoietin in humans at high altitude and its relation to plasma rennin. J. Appl. Physiol. 59:360-364.
17. Pavlicek V., Marti H., Grad S., Gibbs J., Kol C., Wenger R., Gassmann M., Kohl J., Maly F., Olez O., Koller E., and Schirlo C. (2000). Effects of hypobaric hypoxia on vascular endothelial growth factor and the acute phase response in subjects who are susceptible to high-altitude pulmonary oedema. Eur. J. Appl. Physiol. 81:497-503.
18. Pham I., Uchida T., Planes C., Ware L., Kaner R., Matthay M., and Clerici C. (2002). Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo. Am. J. Physiol. Lung Cell. Mol. Physiol. 283: L1133-L1142.
19. Reeves J., Moore L., McCullough R., Harrison G., Tranmer B., Micco A., Tucker A., and Weil J. (1985). Headache at high altitude is not related to internal carotid arterial blood velocity. J. Appl. Physiol. 59:909-915.
20. Roach R., Bartsch P., Hackett P., and Oelz O. (1993). The Lake Louise acute mountain sickness scoring system. In: Hypoxia and Mountain Medicine: Proceedings of the International Hypoxia Symposium. J. Sutton, C. Houston, and G. Coates, eds. Queen City Printers, Burlington, VT; pp. 272-274.
21. Roach R., and Hackett P. (2001). Frontiers of hypoxia research: acute mountain sickness. J. Exper. Bio. 204: 3161-3170.
22. Sandau K., Faus H., and Brune B. (2000). Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway. Biochem. Biophys. Res. Comm. 278: 263-267.
23. Schneider J., Blazy L, Dechaux M., Rabier D., Mason N., and Richalet J.-P. (2001). Response of nitric oxide pathway to L-arginine infusion at the altitude of 4,350 m. Eur. Respir. J. 18:286-292.
24. Sheu M., Chao K., Yen Jen Sung Y., Lin W., Lin-Shiau S., and Liu S. (2005). Activation of phosphoinositide 3-kinase in response to inflammation and nitric oxide leads to the upregulation of cyclooxygenase-2 expression and subsequent cell proliferation in mesangial cells. Cellular Signalling 17:975-984.
25. Silkoff P., McClean P., Slutsky A., Furlott H., Hoffstein E., Wakita S., Chapman K., Szalai J., and Zamel N. (1997). Marked flow-dependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide. Am. J. Respir. Crit. Care Med. 155:260-267.
26. Simon P., Schwartzstein R., Weiss J., Lahive K., Fencl V., Teghtsoonian M., and Weinberger S. (1989). Distinguishable sensations of breathlessness induced in normal volunteers. Am. Rev. Respir. Dis. 140:1021-1027.
27. Tong B.C., and Barbul A. (2004). Cellular and physiological effects of arginine. Mini Rev. Med. Chem. 4:823-832.
28. Van Mil A., Spilt A., Van Buchem M., Bollen E., Teppema L., Westendorp R., and Blauw G. (2002). Nitric oxide mediates hypoxia-induced cerebral vasodilation in humans. J. Appl. Physiol. 92:962-966.
29. Van Osta A., Moraine J., Melot C., Mairbaurl H., Maggiorini M., and Naeije R. (2005). Effects of high altitude exposure on cerebral hemodynamics in normal subjects. Stroke 36:557-560.
30. Witte M., and Barbul A. (2003). Arginine physiology and its implication in wound healing. Wound Rep. Reg. 11:419-423.
31. Wu G., and Morris S. (1998). Arginine metabolism: nitric oxide and beyond. Biochem. J. 336:1-17.