Neutral endopeptidase null mice are less susceptible to high altitude-induced pulmonary vascular leak

High Altitude Medicine and Biology

Volumn 6, Issue 4, 2005, Pages 311-319

  Irwin, David C ^a   Van Patot, Martha Tissot ^b   Tucker, Alan ^a   Bowen, Richard ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Atrial natriuretic peptide; Endothelin 1; Hypoxia; Neprilysin; Pulmonary edema

Indexed keywords

ATRIAL NATRIURETIC FACTOR; ENDOTHELIN 1; MEMBRANE METALLOENDOPEPTIDASE;

ALTITUDE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE PREDISPOSITION; GENE DELETION; GENETIC SUSCEPTIBILITY; GENOTYPE; HEART RIGHT VENTRICLE PRESSURE; HISTOPATHOLOGY; LUNG ARTERY PRESSURE; LUNG BLOOD VESSEL; LUNG FUNCTION; LUNG WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; VASCULAR LESION;

ALTITUDE SICKNESS; ANIMALS; ATRIAL NATRIURETIC FACTOR; CAPILLARY LEAK SYNDROME; CAPILLARY PERMEABILITY; ENDOTHELIN-1; MICE; NEPRILYSIN;

EID: 31344459032     PISSN: 15270297     EISSN: None     Source Type: Journal    
DOI: 10.1089/ham.2005.6.311     Document Type: Article

References (25)

1. Albert T.S., Tucker V.L., and Renkin E.M. (1997). Atrial natriuretic peptide levels and plasma volume contraction in acute alveolar hypoxia. J. Appl. Physiol. 82(1):102-110.
2. Bartsch P. (1999). High altitude pulmonary edema. Med. Sports Sci. 31(1):S23-S27.
3. Bartsch P., Pfluger N. P, Audetat M., Shaw S., Weidmann P., Vock P., Vetter W., Rennie D., and Oelz O. (1991). Effects of slow ascent to 4559 m on fluid homeostasis. Aviat. Space Environ. Med. 62(2):105-110.
4. Carpenter, T.C., Reeves J.T., and Durmowicz A.G. (1998). Viral respiratory infection increases susceptibility of young rats to hypoxia-induced pulmonary edema. J. Appl. Physiol. 84(3):1048-1054.
5. Carpenter, T.C., Schomberg S., Steudal W., Ozimek J., Colvin K., Stenmark K.R., and Ivy D. (2003). Endothelial B receptor deficiency predisposes to pulmonary edema formation via increased lung vascular endothelial cell growth factor expression. Circ. Res. 93:456-463.
6. Carpenter, T.C., and Stenmark K.R (2000). Endothelin receptor blockade decreases lung water in young rats exposed to viral infection and hypoxia. Am. J. Physiol. 279:L547-L554.
7. Carpenter, T.C., and Stenmark K.R. (2001). Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak. J. Appl. Physiol. 281(4):L941-L948.
8. Fagan, K.A., McMurtry I.F., and Rodman D. (2001). Role of endothelin-1 in lung disease. Resp. Res. 2:90-101.
9. Grasemann, H., Lu B., Jiao A., Boudreau, J., Gerard, N.P., and De Sanctis G.T. (1999). Targeted deletion of the neutral endopeptidase gene alters ventilatory response to acute hypoxia. J. Appl. Physiol. 87(4):1266-1271.
10. Hackett, P., and Drummond R. (2002). High-altitude pulmonary edema. JAMA. 287(17):2275-2278.
11. Hackett, P., and Roach R.C. (2002). High altitude illness. N. Engl. J. Med. 345(2):107-114.
12. Hu, R.M., Levin E.R., Pedram A., and Frank H.J.L. (1992). Atrial natriuretic peptide inhibits the production and secretion of endothelin from cultured endothelial cells. J. Biol. Chem. 267:17384-17389.
13. Irwin, D.C., Rhodes J., Baker D.C., Nelson S.E., and Tucker A. (2001). Atrial natriuretic peptide blockade exacerbates high altitude pulmonary edema in endotoxin-primed rats. High Alt. Med. Biol. 2(3):349-360.
14. Irwin, D.C., Tissotvanpatot M., Tucker A., and Bowen R. (2005). Direct ANP inhibition of hypoxia-induced inflammatory pathways in pulmonary microvascular and macrovascular endothelial cells. Am. J. Physiol. 288(5): L2849-L2859.
15. Kawashima, A., Kubo K., Matsuzawa Y., Kobayashi T., and Sekiguchi M. (1992). Hypoxia-induced ANP secretion in subjects susceptible to high-altitude pulmonary edema. Respir. Physiol. 89:309-317.
16. Kedzierski, R., and Yanagisawa M. (2001). Endothelin system: the double-edged sword in health and disease. Annu. Rev. Pharmacol. Toxicol. 41:851-876.
17. Kiemer, A.K., Weber N.C., Furst R., Bildner N., Kulhanek-Heinze S., and Vollmar A.M. (2002). Inhibition of p38 MAPK activation via induction of MKP-1. Atrial natriuretic peptide reduces TNF-a-induced actin polymerization and endothelial permeability. Circ. Res. 90: 874-881.
18. Levin, E.R., Gardner D.G., and Samson W.K. (1998). Natriuretic peptides. Mech. Dis. 339(5):321-328.
19. Lu, B., Figini M., Emaneuli C., Geppetti P., Grady E.F., Gerard N.P., and Bunnet N. (1997). The control of microvascular permeability and blood pressure by neutral endopeptidase. Nat. Med. 3(8):904-907.
20. Maggiorini M., Melot C., Pierre S., Pfeiffer F., Greve I., Sartori C., Lepori M., Hauser M., Scherrer U., and Naeije R. (2001). High-altitude pulmonary edema is initially caused by an increase in capillary pressure. Circ. 103(16):2078-2083.
21. Perreault, T., and Gutkowska, J. (1995). Role of natriuretic factor in lung physiology and pathology. Am. J. Respir. Crit. Care Med. 151:226-242.
22. Porstmann, T., and Kiessig S.T. (1992). Enzyme immunoassay techniques, an overview. J. Immunol. Methods. 150:5-21.
23. Schoene, R. (2004). Unraveling the mechanism of high altitude pulmonary edema. High Alt. Med. Biol. 5(2): 125-135.
24. Thompson, J.S., and Morice A.H. (1996). Neutral endopeptidase inhibitors and the pulmonary circulation. Gen. Pharmacol. 27(4):581-585.
25. West, J.B. (2000). Cellular responses to mechanical stress. Invited review: pulmonary capillary stress failure. J. Appl. Physiol. 89(6):2483-2492.