Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 5, 2006, Pages 1259-1266

  Fu, Hong ^a,b   Marquez, Saul ^a   Gu, Xiangrong ^a   Katz, Leonard ^a   Myles, David C ^a  

^a KOSAN BIOSCIENCES INC   (United States)

^b NONE   (United States)

Author keywords

16 Membered macrolide antibiotics; Oximes; Ribosome binding

Indexed keywords

20 DEOXY 20 (3,5 DIMETHYL LEVO PIPERIDIN LEVO YL) 5 O MYCAMINOSYLTYLONOLIDE; 20 DEOXY 20 (3,5 DIMETHYL LEVO PIPERIDIN LEVO YL) 5 O MYCAMINOSYLTYLONOLIDE 9 OXIME; 5 O MYCAMINOSYLTYLONOLIDE; DESMYCOSIN; ERYTHROMYCIN; MACROLIDE; OXIME DERIVATIVE; POLYACRYLAMIDE GEL; TILMICOSIN; TILMICOSIN 9 OXIME; TYLOSIN; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; HAEMOPHILUS INFLUENZAE TYPE A; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN RNA BINDING; RIBOSOME; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIA;

ALKYLATION; ANTI-BACTERIAL AGENTS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MACROLIDES; METHYLATION; MOLECULAR STRUCTURE; OXIMES; RIBOSOMES; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; HAEMOPHILUS INFLUENZAE SEROTYPE A; NEGIBACTERIA; POSIBACTERIA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS; STREPTOCOCCUS PNEUMONIAE;

EID: 31344454066     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.11.061     Document Type: Article

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