Spontaneous recovery of injured Achilles tendon in inducible nitric oxide synthase gene knockout mice

Inflammation Research

Volumn 55, Issue 1, 2006, Pages 40-45

  Xia, W ^a   Wang, Y ^a   Appleyard, R C ^a   Smythe, G A ^a   Murrell, G A C ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Knockout mice; Nitric oxide synthase; NOS inhibition; Tendon healing

Indexed keywords

AMINOGUANIDINE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRATE; NITRIC OXIDE SYNTHASE INHIBITOR;

ACHILLES TENDON; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; CONTROLLED STUDY; GAS CHROMATOGRAPHY; GENE DELETION; HEALING; KNOCKOUT MOUSE; MASS SPECTROMETRY; MOUSE; NONHUMAN; OSMOTIC MINIPUMP; STATISTICAL SIGNIFICANCE; TENDON INJURY; WILD TYPE;

ACHILLES TENDON; ANIMALS; BIOMECHANICS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENOTYPE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; POLYMERASE CHAIN REACTION; TENDONS; WOUND HEALING;

EID: 31344445272     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-005-0006-4     Document Type: Article

References (40)

1. Enwemeka CS. Inflammation, cellularity, and fibrillogenesis in regenerating tendon: implications for tendon rehabilitation. Phys Ther 1989; 69: 815-25.
2. Gigante A, Specchia N, Rapali S, Ventura A, dePalma, L. Fibrillogenesis in tendon healing: an experimental study. Boll Soc Ital Biol Sper 1996; 72: 203-10.
3. Geller DA, Lowenstein CJ, Shapiro R A, Nussler AK, Di Silvio M, Wand SC et al. Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc Natl Acad Sci USA 1993; 90: 3491-5.
4. Sherman PA, Laubach VE, Reep BR, Wood ER. Purification and cDNA sequence of an inducible nitric oxide Synthase from a human tumor cell line. Biochemistry 1993; 32: 11600-5.
5. Charles IG, Palmer RM, Hickery MS, Baliss MT, Chubb AP, Hall VS et al. Cloning, characterization and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte. Proc Natl Acad Sci USA 1993; 90: 11419-23.
6. Droge W. Free radicals in the physiological control of cells function. Physiol Rev 2002; 82: 47-95.
7. Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J 2001; 357: 593-615.
8. MacMidking J, Xie QW, Nothan C. Nitric oxide and macrophage function. Annu Rev Immunol 1997; 15: 323-50.
9. Ignarro L, Buga G, Wood K, Byrns R, Chaudhuri G. Endotheliumm-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987; 84: 9265-9.
10. Palmer R, Ferrige A, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327: 524-6.
11. Garthwaite S. The nitric oxide-cyclic GMP signaling system in rat brain. Neuropharmacology 1993; 3: 1267.
12. Moncada K. Nitric oxide synthase in mammals. Biochem J 1994; 298: 249.
13. Moilanen E, Vapaatalo H. Nitric oxide in inflammation and immune response. Ann Med 1995; 27: 359-67.
14. Schaffer MR, Tantry U, Gross SS, Wasserburg HL, Barbul A. Nitric oxide regulates wound healing. J Surg Res 1996; 63: 237-40.
15. ShaBani M, Pulfer SK, Bulgrin JP, Smith DJ. Enhancement of wound repair with a topically applied nitric oxide-releasing polymer. Wound Repair Regen 1996; 4: 353-62.
16. Yamasaki K, Edington HD, McClosky C, Tzeng E, Lizonova A, Kovesdi I et al. Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. J Clin Invest 1998; 101: 967-71.
17. Schaffeer MR, Tantry U, Efron PA, Ahrendt GM, Thornton FJ, Barbul A. Diabetes-impaired healing and reduced ound nitric oxide synthesis: a possible pathophysiologic correlation. Surgery 1997; 121: 513-9.
18. Bulgrn JP, Shabanic M, Chakrovarthy D, Smith DJ. Nitric oxide is suppressed in steroid impaired and diabetic wounds. Wound 1995; 7: 48-57.
19. Konturek SJ, Brzozowski T, Majka J, Pytko-Polonczyk J, Stachura J. Inhibition of nitric oxide synthase delays healing of chronic gastric ulcers. Eur J Pharmacol 1993; 239: 215-7.
20. Li M, Chow JYC, Cho CH. Cigarette smoking delays ulcer healing: role of constitutive nitric oxide synthase in rat stomach. Am J Physiol 1999; 276, (Gastrointest. Liver Physiol. 39): G328-248.
21. Murrell GAC, Szabo C, Hannafin JA, Jang D, Dolan MM, Deng XH, Murrell DF. Modulation of tendon healing by nitric oxide. Inflamm Res 1997; 46: 19-27.
22. Lin JH, Wang MX, Wei AQ, Zhu W, Diwan AD, Murrell GAC. Temporal expression of nitric oxide synthase isoforms in healing Achilles tendon. J Orthop Res 2001; 19: 136-42.
23. Lin J, Wang MX, Wei A, Zhu W, Murrell GAC. The cell specific temporal expression of nitric oxide synthase isoforms during Achilles tendon healing. Inflamm Res 2001; 50: 515-22.
24. Diwan AD, Wang MX, Jang D, Zhu W, Murrell GAC. Nitric oxide modulates fracture healing. J Bone Miner Res 2000; 15: 342-51.
25. MacMicking JD, Nathan C, Hom G, Chartrain N, Fletcher DS, Trumbauer M et al. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 1995; 81: 641-50.
26. MacMicking JD, North RJ, LaCourse R, Mudgett JS, Shah SK, Nathan CF. Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc Natl Sci USA 1997; 94: 5243-8.
27. Lairc PW, Zijerveld A, Linders K, Rudnicki MA, Jacnisch R, Berns A. Simplified mammalian DNA isolation procedure. Nucleic Acids Res 1991; 19: 4293.
28. Murrell GAC, Lilly EG, Collins A, Seaber AV, Goldner RD, Best TM. Achilles tendon injuries: a comparison of surgical repair versus no repair in a rat model. Foot & Ankle 1993; 14: 400-6.
29. Best TM, Collins A, Lilly EG, Seaber AV, Goldner R, Murrell GAC. Achilles tendon healing: a correlation between functional and mechanical performance in the rat. J Othorp Res 1993; 11: 987-906.
30. Smythe GA, Matanovic G, Yi D, Duncan MW. Trifluoroacetic anhydride- catalyzed nitration of toluene as an approach to the specific analysis of nitrate by gas chromatography-mass spectrometry. NITRIC OXIDE: Biology and Chemistry 1999; 3: 67-74.
31. Smythe GA, Matanovic G. Specific analysis of nitrate and nitrite by gas chromatography/Mass Spectrometry. Methods Enzymol 2002; 359: 148-57.
32. Poppa V, Miyashiro JK, Corson MA, Berk BC. Endothelial NO Synthase is increased in regenerating endothelium after denuding injury of the rat aorta. Arterioscler Thromb Vasc Biol 1998; 18: 1312-21.
33. Lee PC, Salyapongse AN, Bragdon GA, Shears LL, Watkings SC, Edington HDJ et al. Impaired wound healing and angiogenesis in eNOS-deficient mice. Am J Physiol 1999; 277: (Heart. Circ. Physiol. 46): H1600-H1608.
34. Stallmeyer B, Anhold M, Wetzler C, Kahlina K, Pfeilshcifter J, Frank S. Regulation of eNOS in normal and diabetes-impaired skin repair: implicatioons for tissue regeneration. NITRIC OXIDE: Biology and Chemistry 2002: 6, 168-77.
35. Laroux FS, Pavlick KP, Hines IN, Kawachi S, Harada H, Bharwani S et al. Role of nitric oxide in inflammation. Acta Physiol Scand 2001; 73, 113-8.
36. Kjeldsen TH, Rivier C, Lee S, Hansen EW, Christensen JD, Moesby L. Inducible nitric oxide synthase is responsible for nitric oxide release from murine pituicytes. J Neuroendocrinology 2003; 15: 250-5.
37. Takizawa T, Yoshikawa H, Yamada M, Morita H. Expression of nitric oxide synthase isoforms and detection of nitric oxide in rat placenta. Am J Physiol Cell Physiol 2002; 282: C762-7.
38. Schaffer MR, Tantry U, Thornton FJ, Barbul A. Inhibition of nitric oxide synthesis in wounds: pharmacology and effect on accumulation of collagen in wounds in mice. Eur J Surg 1999; 165: 262-7.
39. Gardiner SM, Bennett T, Kemp PA, Palmer RMJ, Moncada S. Chronic oral ingestioon of nitric oxide synthase inhibitors causes sustained, but reversible, hypertension in Brattleboro rats. In: Moncada S, Marietta MA, Hibbs JB Jr., Higgs E. A., eds. The biology of nitric oxide-I. Physiological and clinical aspects. London: Portland Press 1992: 127-8.
40. McGeorge M, Sherif M, Smirk FH. Observations on the properties of S-methyl-iso-thiourea sulphate, with particular reference to the circulatory effects. J Physiol 1942; 100, 474-83.