Effect of estrogen/progesterone hormone replacement therapy on natural killer cell cytotoxicity and immunoregulatory cytokine release by peripheral blood mononuclear cells of postmenopausal women

Journal of Reproductive Immunology

Volumn 69, Issue 1, 2006, Pages 65-75

  Stopińska Głuszak, Urszula ^a,b   Waligóra, Jacek ^a   Grzela, Tomasz ^a   Głuszak, Michał ^a   Jóźwiak, Jarosław ^a   Radomski, Dariusz ^c,d   Roszkowski, Piotr I ^c   Malejczyk, Jacek ^a  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b Ctr for Postgrad Medical Eduction   (Poland)

^c MEDICAL UNIVERSITY OF WARSAW   (Poland)

^d WARSAW UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Hormone replacement therapy; Interferon ; Interleukin 2; Interleukin 4; Menopause; NK cells; Sex steroids

Indexed keywords

ESTRADIOL; ESTROGEN; FOLLITROPIN; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; MEDROXYPROGESTERONE; PHYTOHEMAGGLUTININ; PROGESTERONE;

ADULT; ARTICLE; CELL ACTIVITY; CELL STIMULATION; CELL STRAIN K 562; CELLULAR IMMUNITY; CLINICAL ARTICLE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXICITY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROLEUKEMIA CELL; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLITROPIN BLOOD LEVEL; HORMONE BLOOD LEVEL; HORMONE SUBSTITUTION; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREGULATION; MENOPAUSAL SYNDROME; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; POSTMENOPAUSE; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL;

ADULT; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; FEMALE; FOLLICLE STIMULATING HORMONE; HUMANS; KILLER CELLS, NATURAL; LEUKOCYTES, MONONUCLEAR; MEDROXYPROGESTERONE; MIDDLE AGED; POSTMENOPAUSE; PROGESTERONE;

EID: 31344444422     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jri.2005.07.006     Document Type: Article

References (34)

1. A.E. Albrecht, B.W. Hartmann, C.H. Scholten, J.C. Huber, W. Kalinowska, and C.C. Zielinski Effect of estrogen replacement therapy on natural killer cell activity in postmenopausal women Maturitas 25 1996 217 222
2. R. Brunelli, D. Frasca, G. Perrone, C. Pioli, A. Fattorossi, L. Zichella, and G. Doria Hormone replacement therapy affects various immune cell subsets and natural cytotoxicity Gynecol. Obstet. Invest. 41 1996 128 131
3. E.M. Curran, L.J. Berghaus, N.J. Vernetti, A.J. Saporita, and D.B. Lubahn Natural killer cells express estrogen receptor-alpha and estrogen-receptor beta and can respond to estrogen via a non-estrogen receptor-alpha-mediated pathway Cell. Immunol. 214 2001 12 20
4. K. Deguchi, M. Kamada, M. Irahara, M. Maegawa, S. Yamamoto, Y. Ohmoto, K. Murata, T. Yasui, S. Yamano, and T. Aono Postmenopausal changes in production of type 1 and type 2 cytokines and the effects of hormone replacement therapy Menopause 8 2001 266 272
5. J. Gabrilovac, J. Zadjelovic, M. Osmak, E. Suchanek, Z. Zupanovic, and M. Boranic NK cell activity and estrogen hormone levels during normal human pregnancy Gynecol. Obstet. Invest. 25 1988 165 172
6. T. Giglio, M.A. Imro, G. Filaci, M. Scudeletti, F. Puppo, D. Cecco, F. Indiveri, and S. Costantini Immune cell circulating subsets are affected by gonadal function Life Sci. 54 1994 1305 1312
7. C.J. Grossman Regulation of the immune system be sex steroids Endocrinol. Rev. 5 1984 435 455
8. N. Hanna Role of natural killer cells in control of cancer metastasis Cancer Metastasis Rev. 1 1982 45 64
9. N. Hanna, and M. Schneider Enhancement of tumor metastasis and suppression of natural killer cell activity by β-estradiol treatment J. Immunol. 130 1983 974 980
10. H.J. Hough, M.L. Failla, and D.A. Ludwig Active lifestyle offsets HRT-induced suppression of T cell reactivity to mitogens Maturitas 33 1999 211 218
11. M. Kamada, M. Irahara, M. Maegawa, Y. Ohmoto, T. Takeji, T. Yasui, and T. Aono Postmenopausal changes in serum cytokine levels and hormone replacement therapy Am. J. Obstet. Gynecol. 184 2001 309 313
12. H.S. Kupperman, M.H. Blatt, H. Wiesbader, and W. Filler Comparative clinical evaluation of estrogenic preparations by the menopausal and amenorreal indices J. Clin. Endocrinol. Metab. 13 1953 688 703
13. R.G. Lahita The role of sex hormones in systemic lupus erythematosus Curr. Opin. Rheumatol. 11 1999 352 356
14. W.B. Malarkey, M. Burleson, J.T. Cacioppo, K. Poehlmann, R. Glaser, and J.K. Kiecolt-Glaser Differential effects of estrogen and medroxyprogesterone on basal and stress-induced growth hormone release, IGF-1 levels, and cellular immunity in postmenopausal women Endocrine 7 1997 227 233
15. J. Malejczyk, S. Majewski, S. Jablonska, T.T. Rogozinski, and G. Orth Abrogated NK-cell lysis of human papillomavirus (HPV)-16-bearing keratinocytes in patients with pre-cancerous and cancerous HPV-induced anogenital lesions Int. J. Cancer 43 1989 209 214
16. J. Malejczyk, M. Malejczyk, S. Majewski, G. Orth, and S. Jablonska NK-cell activity in patients with HPV16-associated anogenital tumors: defective recognition of HPV16-harboring keratinocytes and restricted unresponsiveness to immunostimulatory cytokines Int. J. Cancer 54 1993 917 921
17. I.T. Manyonda, R.S. Pereira, V. Makinde, M. Brincat, and R.T. Varma Effect of 17β-oestradiol on lymphocyte subpopulations, delayed cutaneous hypersensitivity responses, and mixed lymphocyte reactions in postmenopausal women Maturitas 14 1992 201 210
18. R.W. McMurray, K. Ndebele, K.J. Hardy, and J.K. Jenkins 17-Beta-estradiol suppresses IL-2 and IL-2 receptor Cytokine 14 2001 324 333
19. D.J. Oosterlynck, C. Meuleman, M. Waer, M. Vandeputte, and P.R. Koninckx The natural killer activity of peritoneal fluid lymphocytes is decreased in women with endometriosis Fert. Steril. 58 1992 290 295
20. V.R. Porter, G.A. Greendale, M. Schocken, X. Zhu, and R.B. Effros Immune effects of hormone replacement therapy in post-menopausal women Exp. Gerontol. 36 2001 311 326
21. S.L. Reiner, and R.A. Seder T helper cell differentiation in immune response Curr. Opin. Immunol. 8 1995 360 366
22. P. Roszkowski, A. Hyc, and J. Malejczyk Natural killer cell activity in patients with ovarian tumors and uterine myomas Eur. J. Gynaecol. Oncol. 14 Suppl. 1993 114 117
23. P. Roszkowski, A. Hyc, U. Stopińska-Głuszak, and J. Malejczyk Natural killer cell activity and sex hormone levels in mastopathy Gynecol. Endocrinol. 11 1997 399 404
24. M.E. Sabbioni, H.P. Siegrist, M. Bacchi, J. Bernhard, M. Castiglione, B. Thurlimann, H. Bonnefoi, L. Perey, R. Herrmann, A. Goldhirsch, and C. Hurny Association between immunity and prognostic factors in early stage breast cancer patients before adjuvant treatment Breast Cancer Res. Treat. 59 2000 279 287
25. W.E. Seaman, M.A. Blackman, T.D. Ginhart, J.R. Roubinian, J.M. Loeb, and N. Talal β-Estradiol reduces natural killer cells in mice J. Immunol. 121 1978 2193 2198
26. K. Shakhar, G. Shakhar, E. Rosenne, and S. Ben-Eliyahu Timing within the menstrual cycle, sex and the use of oral contraceptives determine adrenergic suppression of NK cell activity Br. J. Cancer 83 2000 1630 1636
27. R. Suenaga, M.J. Evans, K. Mitamura, V. Rider, and N.I. Abdou Peripheral blood T cells and monocytes and B cell lines derived from patients with lupus express estrogen receptor transcripts similar to those of normal cells J. Rheumatol. 25 1998 1305 1312
28. A.N. Sulke, D.B. Jones, and P.J. Wood Variation in natural killer activity in peripheral blood during the menstrual cycle Br. Med. J. 290 1985 884 886
29. F. Tanriverdi, L.F.G. Silveira, G.S. MacColl, and P.M.G. Bouloux The hypothalamic-pituitary-gonadal axis: immune function and autoimmunity J. Endocrinol. 176 2003 293 304
30. T.R. Varma, D. Everard, and D. Hole Effect of natural estrogen on the serum level of follicle-stimulating hormone (FSH), estradiol and estrone in post-menopausal women and its effect on endometrium Acta Obstem. Gynecol. Scand. 64 1985 105 109
31. P.G. Whittaker, M.R. Morgan, P.D. Dean, E.H. Cameron, and T. Lind Serum equilin, oestrone, and oestradiol levels in postmenopausal women receiving conjugated equine oestrogens ('Premarin') Lancet 1 8158 1980 14 16
32. D. White, D.B. Jones, T. Cooke, and N. Kirkham Natural killer (NK) activity in peripheral blood lymphocytes of patients with benign and malignant breast disease Br. J. Cancer 46 1982 611 616
33. J.H. Yang, C.D. Chen, M.Y. Wu, K.H. Chao, Y.S. Yang, and H.N. Ho Hormone replacement therapy reverses the decrease in natural killer cytotoxicity but does not reverse the decreases in the T-cell subpopulation or interferon-gamma production in postmenopausal women Fert. Steril. 74 2000 261 266
34. G. Yovel, K. Shakhar, and S. Ben-Eliyahu The effects of sex, menstrual cycle, and oral contraceptives on the number and activity of natural killer cells Gynecol. Oncol. 81 2001 254 262