Autoreactive T and B cells from bullous pemphigoid (BP) patients recognize epitopes clustered in distinct regions of BP180 and BP230

Journal of Immunology

Volumn 176, Issue 3, 2006, Pages 2015-2023

  Thoma Uszynski, Sybille ^a   Uter, Wolfgang ^a   Schwietzke, Susanne ^a,b   Schuler, Gerold ^a   Borradori, Lnca ^c   Hertl, Michael ^a,b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; BULLOUS PEMPHIGOID ANTIGEN 1; BULLOUS PEMPHIGOID ANTIGEN 180; EPITOPE; IMMUNOGLOBULIN G ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIBODY TITER; ANTIGEN ANTIBODY REACTION; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CARBOXY TERMINAL SEQUENCE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; DERMOEPIDERMAL JUNCTION; DISEASE SEVERITY; FEMALE; HELPER CELL; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; MALE; NONHUMAN; PATHOGENESIS; PEMPHIGOID; PRIORITY JOURNAL; PROTEIN DOMAIN; T LYMPHOCYTE;

EID: 31144466804     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.3.2015     Document Type: Article

References (40)

1. Jordon, R. E., E. H. Beutner, E. Witebsky, G. Blumental, W. L. Hale, and W. F. Lever. 1967. Basement zone antibodies in bullous pemphigoid. J. Am. Med. Assoc. 200: 751-756.
2. Hertl, M. 2000. Humoral and cellular autoimmunity in autoimmune bullous skin disorders. Int. Arch. Allergy Immunol. 122: 91-100.
3. Stanley, J. R., P. Hawley-Nelson, S. H. Yuspa, E. M. Shevach, and S. I. Katz. 1981. Characterization of bullous pemphigoid antigen: a unique basement membrane protein of stratified squamous epithelia. Cell 24: 897-903.
4. Labib, R. S., G. J. Anhalt, H. P. Patel, D. F. Mutasim, and L. A. Diaz. 1986. Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting. J. Immunol. 136: 1231-1235.
5. Stanley, J. R., T. Tanaka, S. Mueller, V. Klaus-Kovtun, and D. Roop. 1988. Isolation of complementary DNA for bullous pemphigoid antigen by use of patients' autoantibodies. J. Clin. Invest. 82: 1864-1870.
6. Giudice, G. J., D. J. Emery, and L. A. Diaz. 1992. Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180. J. Invest. Dermatol. 99: 243-250.
7. Guo, L., L. Degenstein, J. Dowling, Q. C. Yu, R. Wollmann, B. Perman, and E. Fuchs. 1995. Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration. Cell 81: 233-243.
8. Borradori, L., and A. Sonnenberg. 1999. Structure and function of hemidesmosomes: more than simple adhesion complexes. J. Invest. Dermatol. 112: 411-418.
9. Ruhrberg, C., and F. M. Watt. 1997. The plakin family: versatile organizers of cytoskeletal architecture. Curr. Opin. Genet. Dev. 7: 392-397.
10. Thoma-Uszynski, S., W. Uter, S. Schwietzke, S. C. Hofmann, T. Hunziker, P. Bernard, R. Treudler, C. C. Zouboulis, G. Schuler, L. Borradori, and M. Hertl. 2004. BP230- and BP180-specific auto-antibodies in bullous pemphigoid. J. Invest. Dermatol. 122: 1413-1422.
11. Liu, Z., J. M. Shipley, T. H. Vu, X. Zhou, L. A. Diaz, Z. Werb, and R. M. Senior. 1998. Gelatinase B-deficient mice are resistant to experimental bullous pemphigoid. J. Exp. Med. 188: 475-482.
12. Liu, Z., S. D. Shapiro, X. Zhou, S. S. Twining, R. M. Senior, G. J. Giudice, J. A. Fairley, and L. A. Diaz. 2000. A critical role for neutrophil elastase in experimental bullous pemphigoid. J. Clin. Invest. 105: 113-123.
13. Chen, R., G. Ning, M. L. Zhao, M. G. Fleming, L. A. Diaz, Z. Werb, and Z. Liu. 2001. Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid. J. Clin. Invest. 108: 1151-1158.
14. Zillikens, D., P. A. Rose, S. D. Balding, Z. Liu, M. Olague-Marchan, L. A. Diaz, and G. J. Giudice. 1997. Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies. J. Invest. Dermatol. 109: 573-579.
15. Sakuma-Oyama, Y., A. M. Powell, N. Oyama, S. Albert, B. S. Bhogal, and M. M. Black. 2004. Evaluation of a BP180-NC16a enzyme-linked immunosorbent assay in the initial diagnosis of bullous pemphigoid. Br. J. Dermatol. 151: 126-131.
16. Giudice, G. J., D. J. Emery, B. D. Zelickson, G. J. Anhalt, Z. Liu, and L. A. Diaz. 1993. Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain. J. Immunol. 151: 5742-5750.
17. Zillikens, D., F. Caux, J. M. Mascaro, U. Wesselmann, E. Schmidt, C. Prost, J. P. Callen, E. B. Brocker, L. A. Diaz, and G. J. Giudice. 1999. Autoantibodies in lichen planus pemphigoides react with a novel epitope within the C-terminal NC16A domain of BP180. J. Invest. Dermatol. 113: 117-121.
18. Leyendeckers, H., K. Tasanen, L. Bruckner-Tuderman, D. Zillikens, C. Sitaru, J. Schmitz, and N. Hunzelmann. 2003. Memory B cells specific for the NC16A domain of the 180 kDa bullous pemphigoid autoantigen can be detected in peripheral blood of bullous pemphigoid patients and induced in vitro to synthesize autoantibodies. J. Invest. Dermatol. 120: 372-378.
19. Nakatani, C., T. Muramatsu, and T. Shirai. 1998. Immunoreactivity of bullous pemphigoid (BP) autoantibodies against the NC16A and C-terminal domains of the 180 kDa BP antigen (BP180): immunoblot analysis and enzyme-linked immunosorbent assay using BP180 recombinant proteins. Br. J. Dermatol. 139: 365-370.
20. Maczek, C., S. Thoma-Uszynski, G. Schuler, and M. Hertl. 2002. Simultaneous onset of pemphigoid and factor VIII antibody hemophilia. Hautarzt. 53: 412-415.
21. di Zenzo, G., F. Grosso, M. Terracina, F. Mariotti, O. De Pita, K. Owaribe, A. Mastrogiacomo, F. Sera, L. Borradori, and G. Zambruno. 2004. Characterization of the anti-BP180 autoantibody reactivity profile and epitope mapping in bullous pemphigoid patients. J. Invest. Dermatol. 122: 103-110.
22. Mariotti, F., F. Grosso, M. Terracina, M. Ruffelli, P. Cordiali-Fei, F. Sera, G. Zambruno, A. Mastrogiacomo, and G. Di Zenzo. 2004. Development of a novel ELISA system for detection of anti-BP180 IgG and characterization of autoantibody profile in bullous pemphigoid patients. Br. J. Dermatol. 151: 1004-1010.
23. Büdinger, L., L. Borradori, C. Yee, R. Eming, S. Ferencik, H. Grosse-Wilde, H. F. Merk, K. Yancey, and M. Hertl. 1998. Identification and characterization of autoreactive T cell responses to bullous pemphigoid antigen 2 in patients and healthy controls. J. Clin. Invest. 102: 2082-2089.
24. Lin, M. S., M. A. Gharia, S. J. Swartz, L. A. Diaz, and G. J. Giudice. 1999. Identification and characterization of epitopes recognized by T lymphocytes and autoantibodies from patients with herpes gestationis. J. Immunol. 162: 4991-4997.
25. Lin, M. S., C. L. Fu, G. J. Giudice, M. Olague-Marchan, A. M. Lazaro, P. Stastny, and L. A. Diaz. 2000. Epitopes targeted by bullous pemphigoid T lymphocytes and autoantibodies map to the same sites on the bullous pemphigoid 180 ectodomain. J. Invest. Dermatol. 115: 955-961.
26. Hacker-Foegen, M. K., D. Zillikens, G. J. Giudice, and M. S. Lin. 2004. T cell receptor gene usage of BP180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis. Clin. Immunol. 113: 179-186.
27. Black, A. P., S. L. Seneviratne, L. Jones, A. S. King, S. Winsey, G. Arsecularatne, F. Wojnarowska, and G. S. Ogg. 2004. Rapid effector function of circulating NC16A-specific T cells in individuals with mucous membrane pemphigoid. Br. J. Dermatol. 151: 1160-1164.
28. Delgado, J. C., D. Turbay, E. J. Yunis, J. J. Yunis, E. D. Morton, K. Bhol, R. Norman, C. A. Alper, R. A. Good, and R. Ahmed. 1996. A common major histocompatibility complex class II allele HLA-DQB1*0301 is present in clinical variants of pemphigoid. Proc. Natl. Acad. Sci. USA 93: 8569-8571.
29. Setterfield, J., J. Theron, R. W. Vaughan, K. I. Welsh, E. Mallon, F. Wojnarowska, S. J. Challacombe, and M. M. Black. 2001. Mucous membrane pemphigoid: HLA-DQB1*0301 is associated with all clinical sites of involvement and may be linked to antibasement membrane IgG production. Br. J. Dermatol. 145: 406-414.
30. Borradori, L., P. J. Koch, C. M. Niessen, S. Erkeland, M. R. van Leusden, and A. Sonnenberg. 1997. The localization of bullous pemphigoid antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic domain and seems to be regulated by the β4 integrin subunit. J. Cell Biol. 136: 1333-1347.
31. Skaria, M., F. Jaunin, T. Hunziker, S. Riou, H. Schumann, L. Bruckner-Tuderman, M. Hertl, P. Bernard, J. H. Saurat, B. Favre, and L. Borradori. 2000. IgG autoantibodies from bullous pemphigoid patients recognize multiple antigenic reactive sites located predominantly within the B and C subdomains of the COOH-terminus of BP230. J. Invest. Dermatol. 114: 998-1004.
32. Amagai, M., T. Hashimoto, N. Shimizu, and T. Nishikawa. 1994. Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg3) produced by baculovirus. J. Clin. Invest. 94: 59-67.
33. Haase, C., L. Büdinger, L. Borradori, C. Yee, H. F. Merk, K. Yancey, and M. Hertl. 1998. Detection of IgG autoantibodies in the sera of patients with bullous and gestational pemphigoid: ELISA studies utilizing a baculovirus- encoded form of bullous pemphigoid antigen 2. J. Invest. Dermatol. 110: 282-286.
34. Hofmann, S., S. Thoma-Uszynski, T. Hunziker, P. Bernard, C. Koebnick, A. Stauber, G. Schuler, L. Borradori, and M. Hertl. 2002. Severity and phenotype of bullous pemphigoid relate to autoantibody profile against the NH2- and COOH-terminal regions of the BP180 ectodomain. J. Invest. Dermatol. 119: 1065-1073.
35. Witte, S. 2002. Macro for generation of ROC-curves. Proceedings of the 6th Conference of SAS Application in Research and Development, Dortmund, Germany.
36. Lin, M. S., C. L. Fu, M. Olague-Marchan, M. K. Hacker, D. Zillikens, G. J. Giudice, and J. A. Fairley. 2002. Autoimmune responses in patients with linear IgA bullous dermatosis: both autoantibodies and T lymphocytes recognize the NC16A domain of the BP180 molecule. Clin. Immunol. 102: 310-319.
37. Balding, S. D., C. Prost, L. A. Diaz, P. Bernard, C. Bedane, D. Aberdam, and G. J. Giudice. 1996. Cicatricial pemphigoid autoantibodies react with multiple sites on the BP180 extracellular domain. J. Invest. Dermatol. 106: 141-146.
38. Veldman, C. M., K. L. Gebhard, W. Uter, R. Wassmuth, J. Grotzinger, E. Schultz, and M. Hertl. 2004. T cell recognition of desmoglein 3 peptides in patients with pemphigus vulgaris and healthy individuals. J. Immunol. 172: 3883-3892.
39. Sekiguchi, M., Y. Futei, Y. Fujii, T. Iwasaki, T. Nishikawa, and M. Amagai. 2001. Dominant autoimmune epitopes recognized by pemphigus antibodies map to the N-terminal adhesive region of desmogleins. J. Immunol. 167: 5439-5448.
40. Yang, H., E. Goluszko, C. David, D. K. Okita, B. Conti-Fine, T. S. Chan, M. A. Poussin, and P. Christadoss. 2002. Mapping myasthenia gravis-associated T cell epitopes on human acetylcholine receptors in HLA transgenic mice. J. Clin. Invest. 109: 1111-1120.