Rapid effector function of circulating NC16A-specific T cells in individuals with mucous membrane pemphigoid

British Journal of Dermatology

Volumn 151, Issue 6, 2004, Pages 1160-1164

  Black, A P B ^a   Seneviratne, S L ^a   Jones, L ^a   King, A S ^a   Winsey, S ^b   Arsecularatne, G ^b   Wojnarowska, F ^b   Ogg, Graham S ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

BP180; Mucous membrane pemphigoid; NC16A; T cells

Indexed keywords

ANTIGEN; AUTOANTIBODY; GAMMA INTERFERON; MEMBRANE PROTEIN; NC16A ANTIGEN; PROTEIN BP180; UNCLASSIFIED DRUG;

ANTIGEN SPECIFICITY; ARTICLE; BULLOUS SKIN DISEASE; CELL ISOLATION; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; ENZYME LINKED IMMUNOSPOT ASSAY; HUMAN; HUMAN CELL; IMMUNOGENICITY; IMMUNOGLOBULIN A DEFICIENCY; PATHOGENESIS; PEMPHIGOID GESTATIONIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; T LYMPHOCYTE;

AUTOANTIGENS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES, T-LYMPHOCYTE; HUMANS; IMMUNODOMINANT EPITOPES; INTERFERON TYPE II; PEMPHIGOID, BENIGN MUCOUS MEMBRANE; PEMPHIGOID, BULLOUS; T-LYMPHOCYTE SUBSETS;

EID: 11144279155     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2004.06219.x     Document Type: Article

References (23)

1. Li K, Guidice GJ, Tamai K et al. Cloning of partial cDNA for mouse 180-kDa bullous pemphigoid antigen (BPAG2), a highly conserved collagenous protein of the cutaneous basement membrane zone. J Invest Dermatol 1992; 99: 258-63.
2. Balding SD, Prost C, Diaz LA et al. Cicatricial pemphigoid autoantibodies react with multiple sites on the BP180 extracellular domain. J Invest Dermatol 1996; 106: 141-6.
3. Setterfield J, Shirlaw PJ, Kerr-Muir M et al. Mucous membrane pemphigoid: a dual circulating antibody response with IgG and IgA signifies a more severe and persistent disease. Br J Dermatol 1998; 138: 602-10.
4. Nie Z, Hashimoto T. IgA antibodies of cicatricial pemphigoid sera specifically react with C-terminus of BP180. J Invest Dermatol 1999; 112: 254-5.
5. Bernauer W, Wright P, Dart JK et al. Cytokines in the conjunctiva of acute and chronic mucous membrane pemphigoid: an immunohistochemical analysis. Graefes Arch Clin Exp Ophthalmol 1993; 231: 563-70.
6. Elder MJ, Lightman S. The immunological features and pathophysiology of ocular cicatricial pemphigoid. Eye 1994; 8: 196-9.
7. Bernauer W, Wright P, Dart JK et al. The conjunctiva in acute and chronic mucous membrane pemphigoid. An immunohistochemical analysis. Ophthalmology 1993; 100: 339-46.
8. Yunis JJ, Mobini N, Yunis EJ et al. Common major histocampatibility complex class II markers in clinical variants of cicatricial pemphigoid. Proc Natl Acad Sci USA 1994; 91: 7747-51.
9. Setterfield J, Theron J, Vaughan RW et al. Mucous membrane pemphigoid: HLA-DQB1*0301 is associated with all clinical sites of involvement and may be linked to antibasement membrane IgG production. Br J Dermatol 2001; 145: 406-14.
10. Stanley JR, Hawley-Nelson P, Yuspa SH et al. Characterization of bullous pemphigoid antigen: a unique basement membrane protein of stratified squamous epithelia. Cell 1981; 24: 897-903.
11. Stanley SK, Ostrowski MA, Justement JS et al. Effect of immunization with a common recall antigen on viral expression in patients infected with human immunodeficiency virus type 1. N Engl J Med 1996; 334: 1222-30.
12. Labib RS, Anhalt GJ, Patel HP et al. Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting. J Immunol 1986; 136: 1231-5.
13. Giudice GJ, Emery DJ, Zelickson BD et al. Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain. J Immunol 1993; 151: 5742-50.
14. Zillikens D, Rose PA, Balding SD et al. Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies. J Invest Dermatol 1997; 109: 573-9.
15. Budinger L, Borradori L, Yee C et al. Identification and characterization of autoreactive T cell responses to bullous pemphigoid antigen 2 in patients and healthy controls. J Clin Invest 1998; 102: 2082-9.
16. Lin MS, Fu CL, Giudice GJ et al. Epitopes targeted by bullous pemphigoid T lymphocytes and autoantibodies map to the same sites on the bullous pemphigoid 180 ectodomain. J Invest Dermatol 2000; 115: 955-61.
17. Eming R, Budinger L, Riechers R et al. Frequency analysis of autoreactive T-helper 1 and 2 cells in bullous pemphigoid and pemphigus vulgaris by enzyme-linked immunospot assay. Br J Dermatol 2000; 143: 1279-82.
18. Lin MS, Gharia MA, Swartz SJ et al. Identification and characterization of epitopes recognized by T lymphocytes and autoantibodies from patients with herpes gestationis. J Immunol 1999; 162: 4991-7.
19. Lin MS, Fu CL, Olague-Marchan M et al. Autoimmune responses in patients with linear IgA bullous dermatosis: both autoantibodies and T lymphocytes recognize the NC16A domain of the BP180 molecule. Clin Immunol 2002; 102: 310-19.
20. Caproni M, Calzolari A, Giomi B et al. IL-4, IL-5, TGF-beta1 and IFN-gamma mRNAs detected by a new in situ amplification system in cicatricial pemphigoid. Exp Dermatol 2002; 11: 421-7.
21. Caproni M, Calzolari A, Salvatore E et al. Cytokine profile and supposed contribution to scarring in cicatricial pemphigoid. J Oral Pathol Med 2003; 32: 34-40.
22. Sacks EH, Jakobiec FA, Wieczorek R et al. Immunophenotypic analysis of the inflammatory infiltrate in ocular cicatricial pemphigoid. Further evidence for a T cell-mediated disease. Ophthalmology 1989; 96: 236-43.
23. Schmidt E, Skrobek C, Kromminga A et al. Cicatricial pemphigoid: IgA and IgG autoantibodies target epitopes on both intra- and extracellular domains of bullous pemphigoid antigen BP180. Br J Dermatol 2001; 145: 778-83.