Reaction of cytochrome P450 with cumene hydroperoxide: ESR spin-trapping evidence for the homolytic scission of the peroxide O-O bond by ferric cytochrome P450 1A2

Chemical Research in Toxicology

Volumn 9, Issue 1, 1996, Pages 318-325

  Barr, David P ^a   Martin, Martha V ^b   Guengerich, F Peter ^b   Mason, Ronald P ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; CUMENE HYDROPEROXIDE; CYTOCHROME P450; FREE RADICAL; PROPANE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL TISSUE; ARTICLE; COMPUTER SIMULATION; ELECTRON SPIN RESONANCE; ENZYME MECHANISM; ENZYME PURIFICATION; LIPID PEROXIDATION; LIVER MICROSOME; NONHUMAN; OXIDATION; PROTEIN DEGRADATION; RABBIT; REDUCTION; XENOBIOTIC METABOLISM;

ANIMALS; BENZENE DERIVATIVES; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; ELECTRON SPIN RESONANCE SPECTROSCOPY; MICROSOMES, LIVER; OXYGEN; PEROXIDES; RABBITS; SPIN TRAPPING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030068523     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx9501501     Document Type: Article

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