Contribution of an unidentified sodium-dependent nucleoside transport system to the uptake and cytotoxicity of anthracycline in mouse M5076 ovarian sarcoma cells

Biochemical Pharmacology

Volumn 71, Issue 5, 2006, Pages 565-573

  Nagai, Katsuhito ^a   Nagasawa, Kazuki ^a   Koma, Mineto ^a   Kihara, Yukiko ^a   Fujimoto, Sadaki ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Anthracycline; Chemotherapy; De novo resistance; M5076 cell; Nucleoside transport system

Indexed keywords

ANTHRACYCLINE; BILE ACID; CHOLIC ACID; CYTIDINE; CYTIDINE H 3; DOXORUBICIN; MESSENGER RNA; NUCLEOSIDE TRANSPORTER; PIRARUBICIN; SMALL INTERFERING RNA; SODIUM; TAUROCHOLIC ACID; TRITIUM; UNCLASSIFIED DRUG; URIDINE; URIDINE H 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG INHIBITION; DRUG UPTAKE; MALE; MOUSE; NONHUMAN; NUCLEOSIDE TRANSPORT; OVARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOMA CELL; SODIUM CELL LEVEL; SODIUM TRANSPORT;

ANIMALS; ANTHRACYCLINES; BASE SEQUENCE; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; DNA PRIMERS; FEMALE; MICE; NUCLEOSIDES; OVARIAN NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SODIUM;

EID: 31044433586     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.11.017     Document Type: Article

References (25)

1. R.H. Blum, and S.K. Carter Adriamycin. A new anticancer drug with significant clinical activity Ann Intern Med 80 1974 249 259
2. T. Tsuruo, H. Iida, S. Tsukagoshi, and Y. Sakurai 4′-O- Tetrahydropyranyladriamycin as a potential new antitumor agent Cancer Res 42 1982 1462 1467
3. K. Shan, A.M. Lincoff, and J.B. Young Anthracycline-induced cardiotoxicity (see comments) Ann Intern Med 125 1996 47 58
4. S. Mcclean, and B.T. Hill An overview of membrane, cytosolic and nuclear proteins associated with the expression of resistance to multiple drugs in vitro Biochim Biophys Acta 1114 1992 107 127
5. S. Patel, A.U. Sprung, B.A. Keller, V.J. Heaton, and L.M. Fisher Identification of yeast DNA topoisomerase II mutants resistant to the antitumor drug doxorubicin: implications for the mechanisms of doxorubicin action and cytotoxicity Mol Pharmacol 52 1997 658 666
6. K. Nagai, K. Nagasawa, Y. Sadzuka, M. Tsujimoto, K. Takara, and N. Ohnishi Relationships between the in vitro cytotoxicity and transport characteristics of pirarubicin and doxorubicin in M5076 ovarian sarcoma, and comparison with those in Ehrlich ascites carcinoma cells Cancer Chemother Pharmacol 49 2002 244 250
7. K. Nagai, K. Nagasawa, A. Ishimoto, and S. Fujimoto Pirarubicin is taken up by uridine-transportable sodium-dependent concentrative nucleoside transporter in Ehrlich ascites carcinoma cells Cancer Chemother Pharmacol 51 2003 512 518
8. K. Nagai, K. Nagasawa, and S. Fujimoto Uptake of the anthracycline pirarubicin into mouse M5076 ovarian sarcoma cells via a sodium-dependent nucleoside transport system Cancer Chemother Pharmacol 55 2005 222 230
9. W. Kong, K. Engel, and J. Wang Mammalian nucleoside transporters Curr Drug Metab 5 2004 63 84
10. V.M. Kolb Novel and unusual nucleosides as drugs Prog Drug Res 48 1997 195 232
11. C.E. Cass, J.D. Young, and S.A. Baldwin Recent advances in the molecular biology of nucleoside transporters of mammalian cells Biochem Cell Biol 76 1998 761 770
12. +-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib) J Biol Chem 276 2001 2914 2927
13. S.A. Baldwin, S.Y. Yao, R.J. Hyde, A.M. Ng, S. Foppolo, and K. Barnes Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes J Biol Chem 280 2005 15880 15887
14. D.A. Griffith, and S.M. Jarvis Nucleoside and nucleobase transport systems of mammalian cells Biochim Biophys Acta 1286 1996 153 181
15. K. Nagasawa, K. Nagai, A. Ishimoto, and S. Fujimoto Transport mechanism of lovastatin acid in bovine kidney NBL-1 cells: kinetic evidences imply involvement of monocarboxylate transporter 4 Int J Pharm 262 2003 63 73
16. K. Nagasawa, T. Natazuka, K. Chihara, F. Kitazawa, A. Tsumura, and K. Takara Transport mechanism of anthracycline derivatives in human leukemia cell lines: uptake and efflux of pirarubicin in HL60 and pirarubicin-resistant HL60 cells Cancer Chemother Pharmacol 37 1996 297 304
17. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248 254
18. M. Pastor-Anglada, P. Cano-Soldado, M. Molina-Arcas, M.P. Lostao, I. Larrayoz, and J. Martinez-Picado Cell entry and export of nucleoside analogues Virus Res 107 2005 151 164
19. H. Mizutani, S. Tada-Oikawa, Y. Hiraku, M. Kojima, and S. Kawanishi Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide Life Sci 76 2005 1439 1453
20. L. Peng, R. Huang, A.C. Yu, K.Y. Fung, M.P. Rathbone, and L. Hertz Nucleoside transporter expression and function in cultured mouse astrocytes Glia 52 2005 25 35
21. P. Micha, C. Naz, S. Irina, Z. Ying, and R.C. Imogen Differential expression of human nucleoside transporters in normal and tumor tissue Biochem Biophys Res Commun 280 2001 951 959
22. X. Lu, S. Gong, A. Monks, D. Zaharevitz, and J.A. Moscow Correlation of nucleoside and nucleobase transporter gene expression with antimetabolite drug cytotoxicity J Exp Ther Oncol 2 2002 200 212
23. M. Gomez-Angelats, B. Santo, J. Mercader, A. Ferrer-Martinez, A. Felipe, and J. Casado Hormonal regulation of concentrative nucleoside transport in liver parenchymal cells Biochem J 313 1996 915 920
24. C. Soler, R. Valdes, J. Garcia-Manteiga, J. Xaus, M. Comalada, and F.J. Casado Lipopolysaccharide-induced apoptosis of macrophages determines the up-regulation of concentrative nucleoside transporters CNT1 and CNT2 through tumor necrosis factor-alpha-dependent and -independent mechanisms J Biol Chem 276 2001 30043 30049
25. M. Sakowicz, A. Szutowicz, and T. Pawelczyk Differential effect of insulin and elevated glucose level on adenosine transport in rat B lymphocytes Int Immunol 17 2005 145 154