Renal pathology and retinol status in multiple myeloma patients

Kidney International

Volumn 69, Issue 1, 2006, Pages 173-177

  Gavrilov, V ^a,b   Yermiahu, T ^a   Gorodischer, R ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Multiple myeloma; Proximal tubule dysfunction; Retinol status; Urinary retinol

Indexed keywords

CREATININE; RETINOL; RETINOL BINDING PROTEIN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE DURATION; DISEASE MARKER; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; KIDNEY DISEASE; KIDNEY PROXIMAL TUBULE; MULTIPLE MYELOMA; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN URINE LEVEL; SAMPLE SIZE; URINARY EXCRETION;

ADULT; AGED; BETA 2-MICROGLOBULIN; CREATININE; FEMALE; HUMANS; KIDNEY; MALE; MIDDLE AGED; MULTIPLE MYELOMA; RETINOL-BINDING PROTEINS; VITAMIN A;

EID: 30944468761     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5000024     Document Type: Article

References (23)

1. Knudsen LM, Hippe E, Hjorth M et al. Renal function in newly diagnosed multiple myeloma - a demographic study of 1353 patients. The Nordic Myeloma Study Group. Eur J Haematol 1994; 53: 207-212.
2. Herrera GA. Renal manifestations of plasma cell dyscrasias: an appraisal from the patients' bedside to the research laboratory. Ann Diagn Pathol 2000; 4: 174-200.
3. Corrado C, Santarelli MT, Pavlovsky S, Pizzolato M. Prognostic factors in multiple myeloma: definition of risk groups in 410 previously untreated patients: A Grupo Argentino de Tratamiento de la Leucemia Aguda study. J Clin Oncol 1989; 7: 1839-1844.
4. Solomon A, Weiss DT, Katine AA. Nephrotoxic potential of Bence Jones proteins. N Engl J Med 1991; 324: 1845-1851.
5. Pote A, Zwizinski C, Simon EE et al. Cytotoxicity of myeloma light chains in cultured human kidney proximal tubule cells. Am J Kidney Dis 2000; 36: 735-744.
6. Moestrup SK, Verroust PJ. Megalin- and cubilin-mediated endocytosis of protein-bound vitamins, lipids, and hormones in polarized epithelia. Ann Rev Nutr 2001; 21: 407-428.
7. Basu TK, Rowlands L, Jones L, Kohn J. Vitamin A and retinol-binding protein in patients with myelomatosis and cancer of epithelial origin. Eur J Cancer Clin Oncol 1982; 18: 339-342.
8. Clarke BL, Wynne AG, Wilson DM, Fitzpatrick LA. Osteomalacia associated with adult Fanconi's syndrome: clinical and diagnostic features. Clin Endocrinol (Oxf) 1995; 43: 479-490.
9. Baz R, Alemany C, Green R, Hussein MA. Prevalence of vitamin B12 deficiency in patients with plasma cell dyscrasias: a retrospective review. Cancer 2004; 101: 790-795.
10. Leheste JR, Rolinski B, Vorum H et al. Megalin knockout mice as an animal model of low molecular weight proteinuria. Am J Pathol 1999; 155: 1361-1370.
11. Gavrilov V, Yermiahu T, Gorodischer R. Urinary excretion of retinol in patients with multiple myeloma: a preliminary study. Am J Hematol 2003; 74: 202-204.
12. Kanai IM, Raz A, Goodman D. Retinol binding protein: the transport protein for vitamin A in human plasma. J Clin Invest 1968; 47: 2025-2044 (abstract - MEDLINE).
13. Bernard A, Vyskocyl A, Mahieu P, Lauwerys R. Effect of renal insufficiency on the concentration of free retinol-binding protein in urine and serum. Clin Chim Acta 1988; 171: 85-93.
14. Scarpioni L, Dall'aglio PP, Poisetti PG, Buzio C. Retinol binding protein in serum and urine of glomerular and tubular nephropathies. Clin Chim Acta 1976; 68: 107-113.
15. Bernard A, Viau C, Ouled A, Lauwerys R. Competition between low- and high-molecular-weight proteins for renal tubular uptake. Nephron 1987; 45: 115-118.
16. Corso A, Serricchio G, Zappasodi P et al. Assessment of renal function in patients with multiple myeloma: the role of urinary proteins. Ann Hematol 1999; 78: 371-375.
17. Stephensen CB, Alvarez JO, Kohatsu J et al. Vitamin A is excreted in the urine during acute infection. Am J Clin Nutr 1994; 60: 388-392.
18. Fex G, Hansson B. Retinol-binding protein from urine and its interaction with retinol and prealbumin. Eur J Biochem 1979; 94: 307-313.
19. Bernard AM, Moreau D, Lauwerys R. Comparison of retinol-binding protein and beta 2-microglobulin determination in urine for the early detection of tubular proteinuria. Clin Chim Acta 1982; 126: 1-7.
20. Glassock RJ. Circulating permeability factors in the nephrotic syndrome: a fresh look at an old problem. J Am Soc Nephrol 2003; 14: 541-543.
21. De Leenheer AP, De Bevere VO, De Ruyter MG, Claeys AE. Simultaneous determination of retinol and alpha-tocopherol in human serum by high-performance liquid chromatography. J Chromatogr 1979; 162: 408-413.
22. Tomlinson PA, Dalton RN, Turner C, Chantler C. Measurement of beta 2-microglobulin, retinol-binding protein, alpha 1-microglobulin and urine protein 1 in healthy children using enzyme-linked immunosorbent assay. Clin Chim Acta 1990; 192: 99-106.
23. Cleveland WS. Graphical methods for data presentation: full scale breaks, dot charts, and multibased logging. Am Statist 1984; 38: 270-280.