Urinary Excretion of Retinol in Patients with Multiple Myeloma: A Preliminary Study

American Journal of Hematology

Volumn 74, Issue 3, 2003, Pages 202-204

  Gavrilov, Vladimir ^a,b   Yermiahu, Tikva ^a   Gorodischer, Rafael ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Multiple myeloma; Proximal tubule dysfunction; Urinary retinol

Indexed keywords

ALBUMIN; CREATININE; RETINOL;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CREATININE BLOOD LEVEL; FEMALE; HUMAN; KIDNEY DYSFUNCTION; KIDNEY PROXIMAL TUBULE; MALE; MULTIPLE MYELOMA; PRIORITY JOURNAL; PROTEIN URINE LEVEL; URINARY EXCRETION;

ADULT; AGED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CREATININE; FANCONI SYNDROME; FEMALE; HEMOSTASIS; HUMANS; KIDNEY FAILURE; MALE; MIDDLE AGED; MULTIPLE MYELOMA; VITAMIN A;

EID: 0242361655     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajh.10407     Document Type: Article

References (10)

1. Knudsen L, Hippe E, Hjorth M, Holmberg E, Westin J. Renal function in newly diagnosed multiple myeloma, demographic study of 1353 patients. Eur J Haematol 1994;53:207-212.
2. Herrera GA. Renal manifestations of plasma cell dyscrasias: an appraisal from the patients' bedside to the research laboratory. Ann Diagn Pathol 2000;4:174-200.
3. Solomon A, Weiss DT, Katine AA. Nephrotoxic potential of Bence Jones proteins. N Engl J Med 1991;324:1845-1851.
4. Coward RA, Mallick NP, Delamore IW. Tubular function in multiple myeloma. Clin Nephrol 1985;24:180-185.
5. Corso A, Serricchio G, Zappasodi P, et al. Assessment of renal function in patients with multiple myeloma: the role of urinary proteins. Ann Hematol 1999;78:371-375.
6. Christensen EI, Moskaug JO, Vorum H, et al. Evidence for an essential role of megalin in transepithelial transport of retinol. J Am Soc Nephrol 1999;10:685-695.
7. Moestrup SK, Verroust PJ. Megalin- and cubulin-mediated endocytosis of protein-bound vitamins, lipids, and hormones in polarized epithelia. Annu Rev Nutr 2001;21:407-428.
8. Leheste JR, Rolinski B, Vorum H, et al. Megalin knockout mice as an animal model of low molecular weight proteinuria. Am J Pathol 1999;155:1361-1370.
9. Stephensen CB, Alvarez JO, Kohatsu J, Hardmeier R, Kennedy JI, Gammon RB. Vitamin A is excreted in the urine during acute infection. Am J Clin Nutr 1994;60:388-392.
10. Basu TK, Rowlands L, Jones L, Kohn J. Vitamin A and retinol-binding protein in patients with myelomatosis and cancer of epithelial origin. Eur J Cancer Clin Oncol 1982;18:339-342.