The era of biologics and reparative medicine: A pivotal clinical trial of platelet-derived growth factor for periodontal regeneration

Journal of Periodontology

Volumn 76, Issue 12, 2005, Pages 2330-2332

  Reynolds, Mark A ^a   Aichelmann Reidy, Mary Elizabeth ^a  

^a UNIVERSITY OF MARYLAND DENTAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM PHOSPHATE; RECOMBINANT PLATELET DERIVED GROWTH FACTOR;

BONE GRAFT; CLINICAL TRIAL; DOSE RESPONSE; DRUG APPROVAL; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; EDITORIAL; FOLLOW UP; HUMAN; OUTCOME ASSESSMENT; PERIODONTAL DISEASE; PERIODONTIUM; REPARATIVE DENTISTRY; TISSUE REGENERATION; TOOTH RADIOGRAPHY; TREATMENT OUTCOME;

ALVEOLAR BONE LOSS; BONE REGENERATION; DOUBLE-BLIND METHOD; GUIDED TISSUE REGENERATION, PERIODONTAL; HUMANS; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL POCKET; PLATELET-DERIVED GROWTH FACTOR; PROSPECTIVE STUDIES; RANDOMIZED CONTROLLED TRIALS; RECOMBINANT PROTEINS; SAFETY; TREATMENT OUTCOME; WOUND HEALING;

EID: 30944436895     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2005.76.12.2330     Document Type: Editorial

References (26)

1. Wang HL, Greenwell H, Fiorellini J, et al. Periodontal regeneration. J Periodontol 2005;76:1601-1622.
2. Bowers G, Felton F, Middleton C, et al. Histologic comparison of regeneration in human intrabony defects when osteogenin is combined with demineralized freeze-dried bone allograft and with purified bovine collagen. J Periodontol 1991;62:690-702.
3. Bowers GM, Chadroff B, Carnevale R, et al. Histologic evaluation of new attachment apparatus formation in humans. Part III. J Periodontol 1989;60:683-693.
4. Esposito M, Coulthard P, Worthington HV. Enamel matrix derivative (Emdogain) for periodontal tissue regeneration in intrabony defects. Cochrane Database Syst Rev 2003;CD003875.
5. Giannobile WV, Somerman MJ. Growth and amelogenin-like factors in periodontal wound healing. A systematic review. Ann Periodontol 2003;8:193-204.
6. Needleman IG, Giedrys-Leeper E, Tucker RJ, Worthington HV. Guided tissue regeneration for periodontal infra-bony defects. Cochrane Database Syst Rev 2001;CD001724.
7. Reynolds MA, Aichelmann-Reidy ME, Branch-Mays GL, Gunsolley JC. The efficacy of bone replacement grafts in the treatment of periodontal osseous defects. A systematic review. Ann Periodontol 2003;8:227-265.
8. Trombelli L, Heitz-Mayfield LJ, Needleman I, Moles D, Scabbia A. A systematic review of graft materials and biological agents for periodontal intraosseous defects. J Clin Periodontol 2002;29(Suppl. 3):117-135.
9. Nevins M, Giannobile WV, McGuire MK, et al. Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: Results of a large multicenter randomized controlled trial. J Periodontol 2005;76: 2205-2215.
10. Milgrom PM, Hujoel PP, Weinstein P, Holborow DW. Subject recruitment, retention, and compliance in clinical trials in periodontics. Ann Periodontol 1997;2:64-74.
11. Taba M Jr., Jin Q, Sugai J, Giannobile W. Current concepts in periodontal bioengineering. Orthod Craniofac Res 2005;8:292-302.
12. Grazul-Bilska AT, Johnson ML, Bilski JJ, et al. Wound healing: The role of growth factors. Drugs Today 2003;39:787-800.
13. Cortellini P, Bowers GM. Periodontal regeneration of intrabony defects: An evidence-based treatment approach. Int J Periodontics Restorative Dent 1995;15: 128-145.
14. Garrett S. Periodontal regeneration around natural teeth. Ann Periodontol 1996;1:621-666.
15. Rosen PS, Reynolds MA, Bowers GM. The treatment of intrabony defects with bone grafts. Periodontol 2000 2000;22:88-103.
16. Brunsvold MA, Mellonig JT. Bone grafts and periodontal regeneration. Periodontol 2000 1993;1:80-91.
17. Toback GA, Brunsvold MA, Nummikoski PV, Masters LB, Mellonig JT, Cochran DL. The accuracy of radiographic methods in assessing the outcome of periodontal regenerative therapy. J Periodontol 1999; 70:1479-1489.
18. Tonetti MS, Pini Prato G, Williams RC, Cortellini P. Periodontal regeneration of human infrabony defects. III. Diagnostic strategies to detect bone gain. J Periodontol 1993;64:269-277.
19. Murphy KG, Gunsolley JC. Guided tissue regeneration for the treatment of periodontal intrabony and furcation defects. A systematic review. Ann Periodontol 2003;8:266-302.
20. Camelo M, Nevins ML, Schenk RK, Lynch SE, Nevins M. Periodontal regeneration in human Class II furcations using purified recombinant human platelet-derived growth factor-BB (rhPDGF-BB) with bone allograft. Int J Periodontics Restorative Dent 2003; 23:213-225.
21. Nevins M, Camelo M, Nevins ML, Schank RK, Lynch SE. Periodontal regeneration in humans using recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and allogenic bone. J Periodontol 2003; 74:1282-1292.
22. Yukna RA, Krauser JT, Callan DP, Evans GH, Cruz R, Martin M. Multi-center clinical comparison of combination anorganic bovine-derived hydroxyapatite matrix (ABM)/cell binding peptide (P-15) and ABM in human periodontal osseous defects. 6-month results. J Periodontol 2000;71:1671-1679.
23. Mariotti A. Efficacy of chemical root surface modifiers in the treatment of periodontal disease. A systematic review. Ann Periodontol 2003;8:205-226.
24. Nevins ML, Camelo M, Rebaudi A, Lynch SE, Nevins M. Three-dimensional micro-computed tomographic evaluation of periodontal regeneration: A human report of intrabony defects treated with Bio-Oss collagen. Int J Periodontics Restorative Dent 2005;25: 365-373.
25. Freemantle N, Calvert M, Wood J, Eastaugh J, Griffin C. Composite outcomes in randomized trials: Greater precision but with greater uncertainty? JAMA 2003; 289:2554-2559.
26. Lee SJ. Cytokine delivery and tissue engineering. Yonsei Med J 2000;41:704-719.