Clinical and diagnostic findings of an echovirus meningitis outbreak in the north west of England

Postgraduate Medical Journal

Volumn 82, Issue 963, 2006, Pages 60-64

  Carrol, E D ^a   Beadsworth, M B J ^a,b   Jenkins, N ^a   Ratcliffe, L ^a   Ashton, I ^b   Crowley, B ^c   Nye, F J ^a   Beeching, N J ^a  

^a ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^b UNIVERSITY HOSPITAL AINTREE   (United Kingdom)

^c ST JAMES S HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT;

ADOLESCENT; ADULT; ANTIBIOTIC THERAPY; ARTICLE; CEREBROSPINAL FLUID CULTURE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DISEASE DURATION; DISEASE SEVERITY; EARLY DIAGNOSIS; ECHO VIRUS; ENTEROVIRUS; EPIDEMIC; FEMALE; FEVER; HEADACHE; HUMAN; LENGTH OF STAY; MALE; MORBIDITY; MUSCLE STIFFNESS; MYALGIA; NAUSEA; PHOTOPHOBIA; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDY; SMOKING; SYMPTOM; UNITED KINGDOM; VIRUS CULTURE; VIRUS ISOLATION; VIRUS MENINGITIS; VOMITING;

ADOLESCENT; ADULT; DISEASE OUTBREAKS; ECHOVIRUS INFECTIONS; ENGLAND; ENTEROVIRUS B, HUMAN; FEMALE; HUMANS; MALE; MENINGITIS, VIRAL; MIDDLE AGED; PROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 30944433994     PISSN: 00325473     EISSN: None     Source Type: Journal    
DOI: 10.1136/pgmj.2005.036608     Document Type: Article

References (40)

1. Rotbart HA. Enteroviral infections of the central nervous system. Clin Infect Dis 1995;20:971-81.
2. Rotbart HA. Viral meningitis. Semin Neurol 2000;20:277-92.
3. Henquell C, Chambon M, Bailly JL, et al. Prospective analysis of 61 cases of enteroviral meningitis: interest of systematic genome detection in cerebrospinal fluid irrespective of cytologic examination results. J Clin Virol 2001;21:29-35.
4. Cherry J. Enteroviruses, coxsackieviruses, echoviruses, and polioviruses. 4th ed. Philadelphia: Sounders, 1998.
5. Pichkhero ME, McLinn S, Rotbart HA, et al. Clinical and economic impact of enterovirus illness in private pediatric practice. Pediatrics 1998;102:1126-34.
6. Nicolosi A, Hauser WA, Beghi E, et al. Epidemiology of central nervous system infections in Olmsted County, Minnesota, 1950-1981. J Infect Dis 1986;154:399-408.
7. Centers for Disease Control, Prevention (CDC). Outbreaks of aseptic meningitis associated with echoviruses 9 and 30 and preliminary surveillance reports on enterovirus activity - United States, 2003. MMWR Morb Mortal Wkly Rep 2003;52:761-4.
8. Sawyer MH. Enterovirus infections: diagnosis and treatment. Pediatr Infect Dis J 1999;18:1033-9.
9. Thoelen I, Lemey P, Van Der Donck I, et al. Molecular typing and epidemiology of enteroviruses identified from an outbreak of aseptic meningitis in Belgium during the summer of 2000. J Med Virol 2003;70:420-9.
10. Nairn C, Clements GB. A study of enterovirus isolations in Glasgow from 1977 to 1997. J Med Virol 1999;58:304-12.
11. Schumacher JD, Chuard C, Renevey F, et al. Outbreak of echovirus 30 meningitis in Switzerland. Scand J Infect Dis 1999;31:539-42.
12. Rice SK, Heinl RE, Thornton LL, et al. Clinical characteristics, management strategies, and cost implications of a statewide outbreak of enterovirus meningitis. Clin Infect Dis 1995;20:931-7.
13. Oberste MS, Maher K, Kennet ML, et al. Molecular epidemiology and genetic diversity of echovirus type 30 (E30): genotypes correlate with temporal dynamics of E30 isolation. J Clin Microbiol 1999;37:3928-33.
14. Chambon M, Bailly JL, Beguet A, et al. An outbreak due to echovirus type 30 in a neonatal unit in France in 1997: usefulness of PCR diagnosis. J Hosp Infect 1999;43:63-8.
15. Public Health Laboratory Service (PHLS). Viral meningitis in England and Wales associated with an increase of echovirus type 30. CDR Weekly 2001;11:1-3.
16. Chadwick DR, Lever AM. The impact of new diagnostic methodologies in the management of meningitis in adults at a teaching hospital. QJM 2002;95:663-70.
17. Corless CE, Guiver M, Borrow R, et al. Development and evaluation of a 'realtime' RT-PCR for the detection of enterovirus and parechovirus RNA in CSF and throat swab samples. J Med Virol 2002;67:555-62.
18. Verstrepen WA, Bruynseels P, Mertens AH. Evaluation of a rapid real-time RT-PCR assay for detection of enterovirus RNA in cerebrospinal fluid specimens. J Clin Virol 2002;25(suppl 1):S39-43.
19. Pozo F, Casas I, Tenorio A, et al. Evaluation of a commercially available reverse transcription-PCR assay for diagnosis of enteroviral infection in archival and prospectively collected cerebrospinal fluid specimens. J Clin Microbiol 1998;36:1741-5.
20. Guney C, Ozkaya E, Yapar M, et al. Laboratory diagnosis of enteroviral infections of the central nervous system by using a nested RT-polymerase chain reaction (PCR) assay. Diagn Microbiol Infect Dis 2003;47:557-62.
21. Gorgievski-Hrisoho M, Schumacher JD, Vilimonovic N, et al. Detection by PCR of enteroviruses in cerebrospinal fluid during a summer outbreak of aseptic meningitis in Switzerland. J Clin Microbiol 1998;36:2408-12.
22. Buxbaum S, Berger A, Preiser W, et al. Enterovirus infections in Germany: comparative evaluation of different laboratory diagnostic methods. Infection 2001;29:138-42.
23. Bernit E, de Lamballerie X, Zandotti C, et al. Prospective investigation of a large outbreak of meningitis due to echovirus 30 during summer 2000 in Marseilles, France. Medicine (Baltimore) 2004;83:245-53.
24. Nowak DA, Boehmer R, Fuchs HH. A retrospective clinical, laboratory and outcome analysis in 43 cases of acute aseptic meningitis. Eur J Neurol 2003;10:271-80.
25. Carrol ED, Thomson AP, Mobbs KJ, et al. Myositis in children with meningococcal disease: a role for tumour necrosis factor-alpha and interleukin-8? J Infect 2002;44:17-21.
26. Blackwell CC, Tzanakaki G, Kremastinou J, et al. Factors affecting carriage of Neisseria meningitidis among Greek military recruits. Epidemiol Infect 1992;108:441-8.
27. Vieth UC, Kunzelmann M, Diedrich S, et al. An echovirus 30 outbreak with a high meningitis attack rate among children and household members at four day-care centers. Eur J Epidemiol 1999;15:655-8.
28. Reintjes R, Pohle M, Vieth U, et al. Community-wide outbreak of enteroviral illness caused by echovirus 30: a cross-sectional survey and a case-control study. Pediatr Infect Dis J 1999;18:104-8.
29. Chomel JJ, Antona D, Thouvenot D, et al. Three ECHOvirus serotypes responsible for outbreak of aseptic meningitis in Rhone-Alpes region, France. Eur J Clin Microbiol Infect Dis 2003;22:191-3.
30. Oberste MS, Maher K, Kilpatrick DR, et al. Typing of human enteroviruses by partial sequencing of VP1. J Clin Microbiol 1999;37:1288-93.
31. Huang QS, Carr JM, Nix WA, et al. An echovirus type 33 winter outbreak in New Zealand. Clin Infect Dis 2003;37:650-7.
32. Rotbart HA, Ahmed A, Hickey S, et al. Diagnosis of enterovirus infection by polymerase chain reaction of multiple specimen types. Pediatr Infect Dis J 1997;16:409-11.
33. Wang JR, Tsai HP, Huang SW, et al. Laboratory diagnosis and genetic analysis of an echovirus 30-associated outbreak of aseptic meningitis in Taiwan in 2001. J Clin Microbiol 2002;40:4439-44.
34. Ramers C, Billman G, Martin M, et al. Impact of a diagnostic cerebrospinal fluid enterovirus polymerase chain reaction test on patient management. JAMA 2000;283:2680-5.
35. Makwana N, Nye K, Riordan FA. Meningitis without a petechial rash in children in the Hib vaccine era. J Infect 2004;49:297-301.
36. McKinlay MA, Pevear DC, Rossmann MG. Treatment of the picornavirus common cold by inhibitors of viral uncoating and attachment. Annu Rev Microbiol 1992;46:635-54.
37. Abzug MJ, Cloud G, Bradley J, et al. Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis. Pediatr Infect Dis J 2003;22:335-41.
38. Hayden FG, Herrington DT, Coats TL, et al. Efficacy and safety of oral pleconaril for treatment of colds due to picornaviruses in adults: results of 2 double-blind, randomized, placebo-controlled trials. Clin Infect Dis 2003;36:1523-32.
39. Rotbart HA, Webster AD. Treatment of potentially life-threatening enterovirus infections with pleconaril. Clin Infect Dis 2001;32:228-35.
40. Shafran SD, Halota W, Gilbert D, et al. Pleconaril is effective for enteroviral meningitis in adolescents and adults: a randomized placebo controlled multicentrer trial. 39th Interscience conference on antimicrobial agents and chemotherapy, San Francisco, 20-29 Sep 1999; No, 1904.