Weak, physiologically patterned magnetic fields do not affect maze performance in normal rats, but disrupt seized rats normalized with ketamine: Possible support for a neuromatrix concept?

Epilepsy and Behavior

Volumn 8, Issue 1, 2006, Pages 137-144

  McKay, B E ^a   Persinger, M A ^a,b  

^a LAURENTIAN UNIVERSITY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Ketamine; Seizures; Spatial learning; Synergism; Weak magnetic fields

Indexed keywords

KETAMINE; PILOCARPINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DEPTH STIMULATION; CONTROLLED STUDY; ELECTROMAGNETIC FIELD; MALE; MAZE TEST; NONHUMAN; PREDICTION; RAT; SEIZURE; TASK PERFORMANCE; TRAINING;

ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; DISEASE MODELS, ANIMAL; ELECTROMAGNETIC FIELDS; KETAMINE; MALE; MAZE LEARNING; MEMORY; PILOCARPINE; RATS; RATS, WISTAR; SEIZURES;

EID: 30844457717     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2005.11.011     Document Type: Article

References (36)

1. M.P. Honchar J.W. Olney W.R. Sherman Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats Science 222 1983 323-325
2. L. Turski C. Ikonomidou W.A. Turski Z.A. Bortolotto E.A. Cavalheiro Cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: A novel experimental model of intractable epilepsy [review] Synapse 3 1989 154-171
3. W.A. Turski Pilocarpine-induced seizures in rodents - 17 years on Pol J Pharmacol 52 2000 63-65
4. D.A. Coulter D.C. McIntyre W. Loscher Animal models of limbic epilepsies: What can they tell us Brain Pathol 22 2002 240-256
5. D.G. Fujikawa Neuroprotective effect of ketamine administered after status epilepticus onset Epilepsia 36 1995 186-195
6. J. Hort G. Brozek P. Mares M. Langmeier V. Komarek Cognitive functions after pilocarpine-induced status epilepticus: Changes during silent period precede appearance of spontaneous recurrent seizures Epilepsia 40 1999 1177-1183
7. D.J. Borris E.H. Bertram J. Kapur Ketamine controls prolonged status epilepticus Epilepsy Res 42 2000 117-122
8. S.A. Santi L.L. Cook M.A. Persinger R.P. O'Connor Normal spatial memory following postseizure treatment with ketamine: Selective damage attenuates memory deficits in brain-damaged rodents Int J Neurosci 107 2001 63-75
9. L.S. Stewart M.A. Persinger Ketamine prevents learning impairment when administered immediately after status epilepticus onset Epilepsy Behav 2 2001 585-591
10. L.N. Vaillancourt M.A. Persinger Normalization of spatial learning despite brain damage in rats receiving ketamine after seizure-induction: evidence for the neuromatrix Psychol Rep 88 2001 102-110
11. K.K. Borowicz S.J. Czuczwar Effects of etomidate, ketamine or propofol, and their combinations with conventional antiepileptic drugs on amygdala-kindled convulsions in rats Neuropharmacology 45 2003 315-324
12. R. Szakacs R. Weiczner A. Mihaly B. Krisztin-Peva Z. Zador E. Zador Non-competitive NMDA receptor antagonists moderate seizure-induced c-fos expression in the rat cerebral cortex Brain Res Bull 59 2003 485-493
13. N.M. Fournier M.A. Persinger The neuromatrix and the epileptic brain: behavioral and learning preservation in limbic epileptic rats treated with ketamine but not acepromazine Epilepsy Behav 5 2004 119-127
14. B.E. McKay M.A. Persinger Normal spatial and contextual learning for ketamine-treated rats in the pilocarpine epilepsy model Pharmacol Biochem Behav 78 2004 111-119
15. I.S. Midzyanovskaya D.V. Salonin D.Y. Bosnyakova G.D. Kuznetsova E.L. van Luijtelaar The multiple effects of ketamine on electroencephalographic activity and behavior in WAG/Rij rats Pharmacol Biochem Behav 79 2004 83-91
16. L.D. Mewasingh T. Sekhara A. Aeby F.J. Christiaens B. Dan Oral ketamine in paediatric non-convulsive status epilepticus Seizure 12 2003 483-489
17. M.A. Persinger K. Makarec J.C. Bradley Characteristics of limbic seizures evoked by peripheral injections of lithium and pilocarpine Physiol Behav 44 1988 27-37
18. M.A. Persinger Y.R.J. Bureau O. Peredery Dissociation between conditioned taste aversion and radial maze learning following seizure-induced multifocal brain damage: Quantitative tests of serial vs parallel circuit models of memory Physiol Behav 56 1994 225-235
19. M.A. Persinger Y.R.J. Bureau M. Kostakos O. Peredery H. Falter Behaviors of rats with insidious, multifocal brain damage induced by seizures following single peripheral injections of lithium and pilocarpine Physiol Behav 53 1993 849-866
20. W.A. Turski E.A. Cavalheiro M. Schwartz S.J. Czuczwar Z. Kleinrok L. Turski Limbic seizures produced by pilocarpine in rats: Behavioral, electroencephalographic and neuropathological study Behav Brain Res 9 1983 315-335
21. B.E. McKay M.A. Persinger S.A. Koren Exposure to a theta-burst patterned magnetic field impairs memory acquisition and consolidation for contextual but not discrete conditioned fear in rats Neurosci Lett 292 2000 99-102
22. B.E. McKay M.A. Persinger Application timing of complex magnetic fields delineates windows of posttraining-pretesting vulnerability for spatial and motivational behaviors in rats Int J Neurosci 103 2000 69-77
23. S.B. Bausch C. Chavkin Changes in hippocampal circuitry after pilocarpine-induced seizures as revealed by opioid receptor distribution and activation J Neurosci 12 1997 477-492
24. W.E. Lado M.A. Persinger Mechanical impacts to the skulls of rats produce specific deficits in maze performance and weight loss: Evidence for apoptosis of cortical neurons and implications for clinical neuropsychology Percept Motor Skills 97 2003 115-127
25. R.J. Racine Modification of seizure activity by electrical stimulation: II. Motor seizure Electroencephalogr Clin Neurophysiol 32 1972 281-294
26. M.A. Persinger L.S. St-Pierre S.A. Koren Ambulatory behavior in rats following prenatal exposures to complex magnetic fields designed to interact with genetic expression Percept Motor Skills 92 2001 183-192
27. R.E. Dolmetsch K. Xu R.S. Lewis Calcium oscillations increase the efficiency and specificity of gene expression Nature 397 1998 933-936
28. N.A. Aladjalova Slow electrical processes in the brain Progress in brain research, vol. 7 1964 Elsevier New York 20-207
29. M.A. Persinger G. Belanger-Chellew Facilitation of seizures in limbic epileptic rats by complex 1 microTesla magnetic fields Percept Motor Skills 89 1999 486-492
30. D.S. Olton R.J. Samuelson Remembrance of places passed: Spatial memory in rats. J. Exp Psychol Anim Behav 2 1976 97-116
31. L.S. St-Pierre M.A. Persinger S.A. Koren Experimental induction of intermale aggressive behavior in limbic rats by weak, complex magnetic fields: Implications for geomagnetic activity and the modern habitat Int J Neurosci 96 1998 149-159
32. M.A. Persinger The paranormal: The patterns 1974 M.S.S. Information New York
33. M.A. Persinger W.G. Roll S.G. Tiller S.A. Koren M.A. Cook Remote viewing with the artist Ingo Swann: Neuropsychological profile, electroencephalographic correlates, magnetic resonance imaging (MRI) and possible mechanisms Percept Motor Skills 94 2002 927-949
34. W.G. Roll M.A. Persinger D.L. Webster S.G. Tiller C.M. Cook Neurobehavioral and neurometabolic (SPECT) correlates of paranormal information: Involvement of the right hemisphere and its sensitivity to weak complex magnetic fields Int J Neurosci 112 2002 197-224
35. Kant I. Critique of judgement [Bernard JH, Trans.]. New York: Hafner; 1966. p. 258-64.
36. M.A. Persinger On the nature of space-time perception of phenomena in science Percept Motor Skills 88 1999 1210-1216