CYP2D6 polymorphism, tramadol pharmacokinetics and pupillary response

European Journal of Clinical Pharmacology

Volumn 62, Issue 1, 2006, Pages 75-76

  Slanař, Ondřej ^a   Nobilis, Milan ^b   Květina, Jaroslav ^b   Idle, Jeffrey R ^a   Perlík, František ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b INSTITUTE OF MATHEMATICS   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

2 DEMETHYLTRAMADOL; CYTOCHROME P450 2D6; DRUG METABOLITE; TRAMADOL; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA POLYMORPHISM; DRUG BLOOD LEVEL; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; INFRARED RADIATION; LETTER; MIOSIS; NORMAL HUMAN; PRIORITY JOURNAL; PUPIL REFLEX; PUPILLOMETRY;

ANALGESICS, OPIOID; CYTOCHROME P-450 CYP2D6; GENOTYPE; HUMANS; MIOSIS; POLYMORPHISM, GENETIC; PUPIL; TRAMADOL;

EID: 30844456020     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-005-0039-1     Document Type: Letter

References (2)

1. Fliegert F, Kurth B, Gohler K (2005) The effects of tramadol on static and dynamic pupillometry in healthy subjects - the relationship between pharmacodynamics, pharmacokinetics and CYP2D6 metaboliser status. Eur J Clin Pharmacol (published online 20 May, DOI 10.1007/s00228-005-0920-y)
2. Slanař O, Perlík F (2004) CYP2D6 polymorphism and miotic effect of tramadol in healthy volunteers. Drug Metab Rev 36 [Suppl 1]:114