The influence of β-cyclodextrin on the kinetics of progesterone transformation by Rhizopus nigricans

Biocatalysis and Biotransformation

Volumn 23, Issue 5, 2005, Pages 299-305

  Roglič, Urška ^a   Žnidaršič Plazl, Polona ^a   Plazl, Igor ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

cyclodextrin; Hydroxylation; Kinetic model; Progesterone; Rhizopus nigricans

Indexed keywords

DISSOLUTION; FUNGI; HORMONES; HYDROXYLATION; MATHEMATICAL MODELS; SOLUBILITY;

KINETIC MODEL; PROGESTERONE; RHIZOPUS NIGRICANS;

ENZYME KINETICS;

11ALPHA HYDROXYPROGESTERONE; BETA CYCLODEXTRIN; STEROID;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DISSOLUTION; DRUG SYNTHESIS; DRUG TRANSFORMATION; ENZYME KINETICS; FUNGUS CULTURE; FUNGUS GROWTH; HYDROXYLATION; MATHEMATICAL MODEL; MICHAELIS MENTEN KINETICS; NONHUMAN; RHIZOPUS; RHIZOPUS NIGRICANS;

FUNGI; RHIZOPUS; RHIZOPUS STOLONIFER;

EID: 30844451780     PISSN: 10242422     EISSN: 10292446     Source Type: Journal    
DOI: 10.1080/10242420500175929     Document Type: Article

References (19)

1. Angelova, B and Schmauder, H-P. (1999) Lipophilic compounds in biotechnology-interactions with cells and technological problems J Biotechnol, 67, pp. 13 - 32.
2. 11α in detoxification of steroids in the filamentous fungus Rhizopus nigricans J Steroid Biochem Molec Biol, 52(3), pp. 271 - 275.
3. Chen, K-C and Wey, H-C. (1990) Dissolution-enzyme kinetics of 11β-hydroxylation of cortexolone by Curvularia lunata Enzyme Microb Technol, 12, pp. 616 - 621.
4. Fernandes, P and Cruz, A and Angelova, B and Pinheiro, HM and Cabral, JMS. (2003) Microbial conversion of steroid compounds: Recent developments Enzyme Microb Technol, 32, pp. 688 - 705.
5. Fokina, VV and Karpov, AV and Sidorov, IA and Andrjushina, VA and Arinbasarova, A Yu. (1997) The influence of β-cyclodextrin on the kinetics of 1-en-dehydrogenation of 6α-methylhydrocortisone by Arthrobacter globiformis cells Appl Microbiol Biotechnol, 47, pp. 645 - 649.
6. Hanisch, WH and Dunnill, P and Lilly, MD. (1980) Optimization of the production of progesterone 11α-hydroxylase by Rhizopus nigricans Biotechnol Bioeng, 22, pp. 555 - 570.
7. Harper, JB and Easton, CJ and Lincoln, SF. (2000) Cyclodextrins to Increase the Utility of Enzymes in Organic Synthesis Curr Org Chem, 4, pp. 429 - 454.
8. Hesselink, PGM and vanVliet, S and deVries, H and Witholt, B. (1989) Optimization of steroid side chain cleavage by Mycobacterium sp. in the presence of cyclodextrins Enzyme Microb Technol, 11, pp. 398 - 404.
9. Higuchi, T and Connors, K. (1965) Phase-solubility techniques Adv Anal Chem Instrum, 4, pp. 117 - 212.
10. MillerTL. 1985. Steroid fermentations. V: Comprehensive Biotechnology 3 (Blanch, H.W, Drew, S, Wang, D.I.C, Ed.), Pergamon press, 297-318.
11. Murray, HC and Peterson, DH. (1952) Oxygenation of steroids by mucorales fungi US Pat, 2, pp. 602 - 769.
12. Schlosser, D and Irrgang, S and Schmauder, H-P. (1993) Steroid hydroxylation with free and immobilized cells of Penicillium raistrickii in the presence of β-cyclodextrin Appl Microbiol Biotechnol, 39, pp. 6 - 20.
13. Singer, Y and Shity, H and Bar, R. (1991) Microbial transformations in a cyclodextrin medium. Part 2. Reduction of androstenedione to testosterone by Saccharomyces cerevisiae Appl Microbiol Biotechnol, 35, pp. 731 - 737.
14. Szejtli, J.(1988) Cyclodextrin Technology. Dordrecht: Kluwer Academic Publisher.
15. Uekama, K and Fujinaga, T and Hirayama, F and Otagiri, M and Yamasaki, M. (1982) Inclusion complexations of steroid hormones with cyclodextrins in water solid phase Int J Pharm, 10, pp. 1 - 15.
16. Uekama, K and Hirayama, F and Irie, T. (1998) Cyclodextrin drug carrier systems Chem Rev, 98, pp. 2045 - 2076.
17. Žnidaršič, P and Komel, R and Pavko, A. (1998) Studies of a pelleted growth form of Rhizopus nigricans as a biocatalyst for progesterone 11α-hydroxylation J Biotechnol, 60, pp. 207 - 216.
18. ŽnidaršičP2000. Pelleted growth form of Rhizopus nigricans as a biocatalyst for progesterone 11α-hydroxylation. PhD thesis, University of Ljubljana.
19. Žnidaršič, P and Uršic, K and Pavko, A. (2001) Studies on supporting media for progesterone 11α-hydroxylation with a pelleted growth form of Rhizopus nigricans Acta Chim Slov, 48, pp. 533 - 544.