Clinical trial accrual among new cancer patients at a community-based cancer center: A prospective study

Cancer

Volumn 106, Issue 2, 2006, Pages 426-433

  Go, Ronald S ^a   Frisby, Kathleen A ^a   Lee, Jennifer A ^a   Mathiason, Michelle A ^a   Meyer, Christine M ^a   Ostern, Jodi L ^a   Walther, Sara M ^a   Schroeder, Jonean E ^a   Meyer, Lori A ^a   Umberger, Kathryn E ^a  

^a GUNDERSEN LUTHERAN MEDICAL CENTER   (United States)

Author keywords

Accrual; Barriers; Cancer; Clinical trial; Patients

Indexed keywords

ADULT; AGED; ARTICLE; CANCER CENTER; CANCER PATIENT; CLINICAL TRIAL; DECISION MAKING; DEMOGRAPHY; DOCTOR PATIENT RELATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATIENT EDUCATION; PRIORITY JOURNAL; PROSPECTIVE STUDY;

CANCER CARE FACILITIES; CLINICAL TRIALS; HUMANS; NEOPLASMS; PATIENT EDUCATION; PATIENT PARTICIPATION; PATIENT SELECTION; PHYSICIAN-PATIENT RELATIONS; RESIDENCE CHARACTERISTICS;

EID: 30744478228     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.21597     Document Type: Article

References (49)

1. Tejeda HA, Green SB, Trimble EL, et al. Representation of African-Americans, Hispanics, and whites in National Cancer Institute cancer treatment trials. J Natl Cancer Inst. 1996;88:812-816.
2. Sateren WB, Trimble EL, Abrams J, et al. How sociodemographics, presence of oncology specialists, and hospital cancer programs affect accrual to cancer treatment trials. J Clin Oncol. 2002;20:2109-2117.
3. Lee JY, Breaux SR. Accrual of radiotherapy patients to clinical trials. Cancer. 1983;52:1014-1016.
4. Martin JF, Henderson WG, Zacharski LR, et al. Accrual of patients into a multihospital cancer clinical trial and its implications on planning future studies. Am J Clin Oncol. 1984;7:173-182.
5. Hunter CP, Frelick RW, Feldman AR, et al. Selection factors in clinical trials: results from the Community Clinical Oncology Program Physician's Patient Log. Cancer Treat Rep. 1987;71:559-565.
6. Goodwin JS, Hunt WC, Humble CG, et al. Cancer treatment protocols. Who gets chosen? Arch Intern Med. 1988;148:2258-2260.
7. Fisher WB, Cohen SJ, Hammond MK, et al. Clinical trials in cancer therapy: efforts to improve patient enrollment by community oncologists. Med Pediatr Oncol. 1991;19:165-168.
8. Benson AB 3rd, Pregler JP, Bean JA, et al. Oncologists' reluctance to accrue patients onto clinical trials: an Illinois Cancer Center study. J Clin Oncol. 1991;9:2067-2075.
9. Kotwall CA, Mahoney LJ, Myers RE, et al. Reasons for non-entry in randomized clinical trials for breast cancer: a single institutional study. J Surg Oncol. 1992;50:125-129.
10. Krailo MD, Bernstein L, Sullivan-Halley J, et al. Patterns of enrollment on cooperative group studies. An analysis of trends from the Los Angeles County Cancer Surveillance Program. Cancer. 1993;71(Suppl 10):3325-3330.
11. Avent RA, Dillman RO. Cancer clinical trials in the community setting: a 20-year retrospective. Cancer Biother. 1995;10:95-113.
12. Mouton CP, Harris S, Rovi S, et al. Barriers to black women's participation in cancer clinical trials. J Natl Med Assoc. 1997;89:721-727.
13. Fuks A, Weijer C, Freedman B, et al. A study in contrasts: eligibility criteria in a twenty-year sample of NSABP and POG clinical trials. National Surgical Adjuvant Breast and Bowel Program. Pediatric Oncology Group. J Clin Epidemiol. 1998;51:69-79
14. Chamberlain RM, Winter KA, Vijayakumar S, et al. Sociodemographic analysis of patients in radiation therapy oncology group clinical trials. Int J Radiat Oncol Biol Phys. 1998;40:9-15.
15. Klabunde CN, Springer BC, Butler B, et al. Factors influencing enrollment in clinical trials for cancer treatment. South Med J. 1999;92:1189-1193.
16. Hutchins LF, Unger JM, Crowley JJ, et al. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med. 1999;341:2061-2067.
17. Jenkins V, Fallowfield L. Reasons for accepting or declining to participate in randomized clinical trials for cancer therapy. Br J Cancer. 2000;82:1783-1788.
18. Alexander GA, Chu KC, Ho RC. Representation of Asian Americans in clinical cancer trials. Ann Epidemiol. 2000;10(Suppl 8):S61-S67.
19. Ling J, Rees E, Hardy J. What influences participation in clinical trials in palliative care in a cancer centre? Eur J Cancer. 2000;36:621-626.
20. Siminoff LA, Zhang A, Colabianchi N, et al. Factors that predict the referral of breast cancer patients onto clinical trials by their surgeons and medical oncologists. J Clin Oncol. 2000;18:1203-1211.
21. Lara PN Jr., Higdon R, Lim N, et al. Prospective evaluation of cancer clinical trial accrual patterns: identifying potential barriers to enrollment. J Clin Oncol. 2001;19:1728-1733.
22. Collaborative Ocular Melanoma Study Group. Sociodemographic and clinical predictors of participation in two randomized trials: findings from the Collaborative Ocular Melanoma Study COMS report no. 7. Control Clin Trials. 2001;22:526-537.
23. Chang SM, Barker FG 2nd, Schmidt MH, et al. Clinical trial participation among patients enrolled in the Glioma Outcomes Project. Cancer. 2002;94:2681-2687.
24. Kornblith AB, Kemeny M, Peterson BL, et al. Cancer and Leukemia Group B. Survey of oncologists' perceptions of barriers to accrual of older patients with breast carcinoma to clinical trials. Cancer. 2002;95:989-996.
25. Grunfeld E, Zitzelsberger L, Coristine M, et al. Barriers and facilitators to enrollment in cancer clinical trials: qualitative study of the perspectives of clinical research associates. Cancer. 2002;95:1577-1583.
26. Mannel RS, Walker JL, Gould N, et al. Impact of individual physicians on enrollment of patients into clinical trials. Am J Clin Oncol. 2003;26:171-173.
27. Lewis JH, Kilgore ML, Goldman DP, et al. Participation of patients 65 years of age or older in cancer clinical trials. J Clin Oncol. 2003;21:1383-1389.
28. Yee KW, Pater JL, Pho L, et al. Enrollment of older patients in cancer treatment trials in Canada: why is age a barrier? J Clin Oncol. 2003;21:1618-1623.
29. Advani AS, Atkeson B, Brown CL, et al. Barriers to the participation of African-American patients with cancer in clinical trials: a pilot study. Cancer. 2003;97:1499-1506.
30. Kemeny MM, Peterson BL, Kornblith AB, et al. Barriers to clinical trial participation by older women with breast cancer. J Clin Oncol. 2003;21:2268-2275.
31. Solomon MJ, Pager CK, Young JM, et al. Patient entry into randomized controlled trials of colorectal cancer treatment: factors influencing participation. Surgery. 2003;133:608-613.
32. Comis RL, Miller JD, Aldige CR, et al. Public attitudes toward participation in cancer clinical trials. J Clin Oncol. 2003;21:830-835.
33. Murthy VH, Krumholz HM, Gross CP. Participation in cancer clinical trials: race-, sex-, and age-based disparities. JAMA. 2004;291:2720-2726.
34. Flory J, Emanuel E. Interventions to improve research participants' understanding in informed consent for research: a systematic review. JAMA. 2004;292:1593-1601.
35. Adams-Campbell LL, Ahaghotu C, Gaskins M, et al. Enrollment of African Americans onto clinical treatment trials: study design barriers. J Clin Oncol. 2004;22:730-734.
36. Gross CP, Murthy V, Li Y, et al. Cancer trial enrollment after state-mandated reimbursement. J Natl Cancer Inst. 2004;96:1063-1069.
37. Simon MS, Du W, Flaherty L, et al. Factors associated with breast cancer clinical trials participation and enrollment at a large academic medical center. J Clin Oncol. 2004;22:2046-2052.
38. Wright JR, Whelan TJ, Schiff S, et al. Why cancer patients enter randomized clinical trials: exploring the factors that influence their decision. J Clin Oncol. 2004;22:4312-4318.
39. Newman LA, Hurd T, Leitch M, et al. A report on accrual rates for elderly and minority-ethnicity cancer patients to clinical trials of the American College of Surgeons Oncology Group. J Am Coll Surg. 2004;199:644-651.
40. Talarico L, Chen G, Pazdur R. Enrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US Food and Drug Administration. J Clin Oncol. 2004;22:4626-4631.
41. Moore DH, Kauderer JT, Bell J, et al. An assessment of age and other factors influencing protocol versus alternative treatments for patients with epithelial ovarian cancer referred to member institutions: a Gynecologic Oncology Group study. Gynecol Oncol. 2004;94:368-374.
42. Gross CP, Filardo G, Mayne ST, et al. The impact of socioeconomic status and race on trial participation for older women with breast cancer. Cancer. 2005;103:483-491.
43. Cobau CD. Clinical trials in the community. The community clinical oncology program experience. Cancer. 1994;74:2694-2700.
44. Cohen G. Cancer clinical trials: a primer for participation of community physicians. In: Perry MC, editor. American Society of Clinical Oncology 2002 Education Book. Baltimore: Lippincott Williams and Wilkins, 2002:283-289.
45. Jemal A, Murray T, Ward E, et al. Cancer statistics, 2005. CA Cancer J Clin. 2005;55:10-30.
46. Basch EM, Elkin EB, Siegel E, et al. Availability of therapeutic trials based on cancer site and stage [abstract]. 2004 ASCO Annual Meeting Proceedings (Post-Meeting Edition). J Clin Oncol. 2004;22(14S):6015.
47. National Cancer Institute. Clinical trials and insurance coverage-a resource guide. Bethesda, MD: National Cancer Institute, 1999. Available at URL: http://www.cancer.gov/clinicaltrials/understanding/insurance-coverage [access date].
48. National Cancer Institute. States that require health plans to cover patient care costs in clinical trials. Bethesda, MD: National Cancer Institute, Year. Available at URL: http://www.cancer.gov/clinicaltrials/learning/laws- about-clinicaltrial-costs [accessed July 11, 2005].
49. United States Census. American FactFinder. Washington, DC: United States Census Bureau, Year. Available at URL: http://factfinder.census.gov [accessed July 11, 2005].