Solubility of silybin in aqueous poly(ethylene glycol) solution

International Journal of Pharmaceutics

Volumn 308, Issue 1-2, 2006, Pages 100-106

  Bai, Tong Chun ^a   Yan, Guo Bing ^a   Hu, Jie ^a   Zhang, Hua Li ^a   Huang, Cheng Gang ^b  

^a SOOCHOW UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Poly(ethylene glycol); Silybin; Solubility; The Universal Quasi Chemical (UNIQUAC) model

Indexed keywords

MACROGOL 6000; SILIBININ;

AQUEOUS SOLUTION; ARTICLE; CRYSTALLIZATION; DRUG ACTIVITY; DRUG EFFECT; DRUG SOLUBILITY; DRUG STRUCTURE; ENTHALPY; ENTROPY; MATHEMATICAL COMPUTING; PRIORITY JOURNAL; SOLUBILIZATION; TEMPERATURE; THERMODYNAMICS;

MILK THISTLE; MODELS, CHEMICAL; POLYETHYLENE GLYCOLS; SILYMARIN; SOLUBILITY; SOLVENTS; TEMPERATURE; THERMODYNAMICS;

EID: 30744476499     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.10.032     Document Type: Article

References (17)

1. W.E. Acree Thermodynamic Properties of Nonelectrofyte Solutions 1984 Academic Press Inc. Oriando
2. F. Damian, N. Blaton, L. Naesens, J. Balzarini, R. Kinget, P. Augustijns, and G. Van den Mooter Physicochemical characterization of solid dispersions of the antiviral agent UC-781 with polyethylene glycol 6000 and Gelucire 44/14 Eur. J. Pharm. Sci. 10 2000 311 322
3. J. Jinno, D.M. Oh, J.R. Crison, and G.L. Amidon Dissolution of ionisable water-insoluble drugs: the combined effect of pH and surfactant J. Pharm. Sci. 89 2000 268 274
4. M.N. Jones Biochemical Thermodynamics second ed. 1988 Elsevier
5. A. Jouyban-Gharamaleki, and W.E. Acree Jr. Comparison of models for describing multiple peaks in solubility profiles Int. J. Pharm. 167 1998 177 182
6. A. Jouyban-Gharamaleki, L. Valaee, M. Barzegar-Jalali, B.J. Clark, and W.E. Acree Jr. Comparison of various cosolvency models for calculating solute solubility in water-cosolvent mixtures Int. J. Pharm. 177 1999 93 101
7. A. Jouyban-Gharamaleki, P. York, M. Hanna, and B.J. Clark Solubility prediction of salmeterol xinafoate in water-dioxane mixtures Int. J. Pharm. 216 2001 33 41
8. P. Kallinteri, and S.G. Antimisiaris Solubility of drugs in the presence of gelatin: effect of drug lipophilicity and degree of ionization Int. J. Pharm. 221 2001 219 226
9. F. Kvasnicka, B. Biba, R. Sevcik, M. Voldrich, and J. Kratka Analysis of the active components of silymarin J. Chromatogr. A. 990 2003 239 245
10. B.L. Larsen, P. Rasmussen, and A. Fredenslund A modified UNIFAC group-contribution model for prediction of phase equilibria and heat of mixing Ind. Eng. Chem. Res. 26 1987 2274 2286
11. F.-Q. Li, J.-H. Hu, and Y.-Y. Jiang Preparation and characterization of solid dispersions of silymarin with polyethylene glycol 6000 J. Chin. Pharm. Sci. 12 2003 76 81
12. T.H. Lilley Interactions in solutions: the interplay between solute solvation and solute-solute interactions Pure Appl. Chem. 66 1994 429 434
13. R.C. Reid, J.M. Prausnitz, and B.E. Poling The Properties of Gases and Liquids fourth ed. 1987 McGraw-Hill Book Company New York p. 372
14. G. Reinwald, and I. Zimmermann A combined calorimetric and semiempirical quantum chemical approach to describe the solution thermodynamics of drugs J. Pharm. Sci. 87 1998 745 750
15. G. Van den Mooter, M. Wuyts, N. Blaton, R. Busson, P. Grobet, P. Augustijns, and R. Kinget Physical stabilisation of amorphous ketoconazole in solid dispersions with polyvinylpyrrolidone K25 Eur. J. Pharm. Sci. 12 2001 261 269
16. S. Verheyen, N. Blaton, R. Kinget, and G. Van den Mooter Mechanism of increased dissolution of diazepam and temazepam from polyethylene glycol 6000 solid dispersions Int. J. Pharm. 249 2002 45 58
17. H. Viernstein, P. Weiss-Greiler, and P. Wolschann Solubility enhancement of low soluble biologically active compounds - temperature and cosolvent dependent inclusion complexation Int. J. Pharm. 256 2003 85 94