Intravenous immunoglobulin in the prevention of recurrent miscarriage: Does it work?

Chemical Immunology and Allergy

Volumn 88, Issue , 2005, Pages 117-127

  Christiansen, Ole B ^a   Nielsen, Henriette S ^a  

^a Rigshospitalet   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN; PLACEBO;

ALLERGIC REACTION; ARTHRALGIA; CLINICAL TRIAL; CYTOKINE PRODUCTION; DRUG COST; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG SAFETY; ECONOMIC ASPECT; FETUS DEATH; GESTATION PERIOD; HUMAN; IMMUNIZATION; IMMUNOPATHOLOGY; LEUKOCYTE; META ANALYSIS; NONHUMAN; PREGNANCY OUTCOME; PRIORITY JOURNAL; RASH; RECURRENT DISEASE; REVIEW; SPONTANEOUS ABORTION; SYSTEMATIC REVIEW; URTICARIA;

EID: 30744459876     PISSN: 16602242     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000087829     Document Type: Review

References (28)

1. Christiansen OB: A fresh look at the causes and treatments of recurrent miscarriage, especially its immunological aspects. Hum Reprod Update 1996;2:271-293.
2. Laskin CA, Bombardier C, Hannah ME, Mandel FP, Ritchie JW, Farewell V, Farine D, Spitzer K, Fielding L, Soloninka CA, Yeung M: Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal loss. N Engl J Med 1997;337:148-153.
3. Scott JR: Immunotherapy for recurrent miscarriage. Cochrane Database Syst Rev 2003;1:CD000112.
4. Daya S, Gunby J and the Recurrent Miscarriage Immunotherapy Trialists Group: The effectiveness of allogeneic leukocyte immunization in unexplained primary recurrent spontaneous abortion. Am J Reprod Immunol 1994;32:294-302.
5. Bayry J, Misra N, Latry V, Prost F, Delignat S, Lacroix-Desmazes S, Kazatchkine MD, Kaveri SV: Mechanisms of action of intravenous immunoglobulin in autoimmune and inflammatory diseases. Transfus Clin Biol 2003;10:165-169.
6. Marzusch K, Dietl J, Klein R, Hornung D, Neuer A, Berg PA: Recurrent first trimester spontaneous abortion associated with antiphospholipid antibodies: A pilot study of treatment with intravenous immunoglobulin. Acta Obstet Gynecol Scand 1996;75:922-926.
7. Kwak JYH, Kwak FMY, Ainbinder SW, Ruiz AM, Beer AE: Elevated peripheral blood natural killer cells are effectively suppressed by immunoglobulin G infusions in women with recurrent spontaneous abortions. Am J Reprod Immunol 1996;35:363-369.
8. The German RSA/IVIG Group: Intravenous immunoglobulin in the prevention of recurrent miscarriage. Br J Obstet Gynaecol 1994;101:1072-1077.
9. Christiansen OB, Mathiesen O, Husth M, Rasmussen KL, Ingerslev HJ, Lauritsen JG, Grunnet N: Placebo-controlled trial of treatment of unexplained secondary recurrent spontaneous abortions and recurrent late spontaneous abortions with i.v. immunoglobulin. Hum Reprod 1995; 10:2690-2695.
10. Coulam C, Krysa L, Stern J, Bustillo M: Intravenous immunoglobulin for treatment of recurrent pregnancy loss. Am J Reprod Immunol 1995;34:333-337.
11. Stephenson MD, Dreher K, Houlihan E, Wu V: Prevention of unexplained recurrent spontaneous abortion using intravenous immunoglobulin: A prospective, randomized, double-blinded, placebo-controlled trial. Am J Reprod Immunol 1998;39:82-88.
12. Perino A, Vassiliadis A, Vucetich A, Colacurci N, Menato G, Cignitti M, Semprini AE: Short-term therapy for recurrent abortion using intravenous immunoglobulins: Results of a double-blind placebo-controlled Italian study. Hum Reprod 1997;12:2388-2392.
13. Jablonowska B, Selbing A, Palfi M, Ernerudh J, Kjellberg S, Lindton B: Prevention of recurrent spontaneous abortion by intravenous immunoglobulin: A double-blind placebo-controlled study. Hum Reprod 1999;14:838-841.
14. Christiansen OB, Pedersen B, Rosgaard A, Husth M: A randomized, double-blind placebo-controlled trial of intravenous immunoglobulin in the prevention of recurrent miscarriage: Evidence for a therapeutic effect in women with secondary recurrent miscarriage. Hum Reprod 2002; 17:809-816.
15. Daya S, Gunby J, Porter F, Scott J, Clark DA: Critical analysis of intravenous immunoglobulin therapy for recurrent miscarriage. Hum Reprod Update 1999;5:475-482.
16. Coulam CB: Immunological tests in the evaluation of reproductive disorders: A critical review. Am J Obstet Gynecol 1992;167:1844-1851.
17. The Recurrent Miscarriage Immunotherapy Trialists Group: Worldwide collaborative observational study and meta-analysis on allogeneic leukocyte immunotherapy for recurrent spontaneous abortion. Am J Reprod Immunol 1994;32:55-72.
18. Christiansen OB, Pedersen B, Nielsen HS, Nybo Andersen AM: Impact of the sex of first child on the prognosis in secondary recurrent miscarriage. Hum Reprod 2004;19:2946-2951.
19. Christiansen OB, Mathiesen O, Lauritsen JG, Grunnet N: Intravenous immunoglobulin treatment of women with multiple miscarriages. Hum Reprod 1992;7:718-722.
20. Christiansen OB, Nielsen HS, Pedersen B: Active or passive immunization in unexplained recurrent miscarriage. J Reprod Immunol 2004;62:41-52.
21. Kruse C, Steffensen R, Varming K, Christiansen OB: A study of HLA-DR and -DQ alleles in 588 patients and 562 controls confirms that HLA-DRB1*03 is associated with recurrent miscarriage. Hum Reprod 2004;19:1215-1221.
22. Pfeiffer KA, Fimmers R, Engels G, van der Ven H, van der Ven K: The HLA-G genotype is potentially associated with idiopathic recurrent spontaneous abortion. Mol Hum Reprod 2001; 7:373-378.
23. Ogasawara M, Aoki K, Okada S, Suzumori K: Embryonic karyotype of abortuses in relation to the number of previous miscarriages. Fertil Steril 2000;73:300-304.
24. Carp HJ, Toder V, Gazit E, Ahiron R, Torchinsky A, Mashiach S, Shoenfeld Y. Further experience with intravenous immunoglobulin in women with recurrent miscarriage and a poor prognosis. Am J Reprod Immunol 2001;46:268-273.
25. Imbach P, Baradun S, d'Apuzzo V, Baumgartner C, Hirt A, Morell A, Rossi E, Schoni M, Vest M, Wagner HP: High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood. Lancet 1981;i:1228-1231.
26. Mazer BD, Gelfand EW: An open-label study of high dose intravenous immunoglobulin in severe childhood asthma. J Allergy Clin Immunol 1991;87:976-983.
27. Brigham SA, Conlon C, Farquharson RG: A longitudinal study of pregnancy outcome following idiopathic recurrent miscarriage. Hum Reprod 1999;14:2868-2871.
28. Späth PJ, Kempf C: Challenges and achievements in pathogen safety of intravenous immunoglobulin; in Dalakas MC, Späth PJ (eds): Intravenous Immunoglobulins in the Third Millennium. Boca Raton, Parthenon Publishing, 2004, pp 9-20.