A RUNX/AML-binding motif residing in a novel 13-bp DNA palindrome may determine the expression of the proximal promoter of the human uPA gene

Journal of Thrombosis and Haemostasis

Volumn 3, Issue 9, 2005, Pages 2057-2064

  Kopf, E ^a   Miskin, Ruth ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

AML; MLLT1; MYH11; Palindrome; RUNX; Urokinase type plasminogen activator gene promoter

Indexed keywords

DNA; TRANSCRIPTION FACTOR RUNX1; UROKINASE RECEPTOR;

ARTICLE; BONE MARROW CULTURE; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; EMBRYO; GEL MOBILITY SHIFT ASSAY; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENETIC TRANSFECTION; HEMATOPOIESIS; HUMAN; HUMAN CELL; LEUKEMIA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

AMINO ACID MOTIFS; BASE SEQUENCE; CELL LINE; CORE BINDING FACTOR ALPHA 2 SUBUNIT; DNA; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; REPETITIVE SEQUENCES, NUCLEIC ACID; TRANSFECTION; URINARY PLASMINOGEN ACTIVATOR;

EID: 30644471406     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2005.01510.x     Document Type: Article

References (38)

1. Blasi F, Carmeliet P. uPAR: a versatile signalling orchestrator. Nat Rev Mol Cell Biol 2002; 3: 932-43.
2. Choong PF, Nadesapillai AP. Urokinase plasminogen activator system: a multifunctional role in tumor progression and metastasis. Clin Orthop 2003; 415: S46-58.
3. Irigoyen JP, Munoz-Canoves P, Montero L, Koziczak M, Nagamine Y. The plasminogen activator system: biology and regulation. Cell Mol Life Sci 1999; 56: 104-32.
4. Besser D, Verde P, Nagamine Y, Blasi F. Signal transduction and the u-PA/u-PAR system. Fibrinolysis 1996; 10: 215-37.
5. Wilson EL, Francis GE. Differentiation-linked secretion of urokinase and tissue plasminogen activator by normal human hematopoietic cells. J Exp Med 1987; 165: 1609-23.
6. Wilson EL, Jacobs P, Dowdle EB. The secretion of plasminogen activators by human myeloid leukemic cells in vitro. Blood 1983; 61: 568-74.
7. Tapiovaara H, Alitalo R, Stephens R, Myohanen H, Ruutu T, Vaheri A. Abundant urokinase activity on the surface of mononuclear cells from blood and bone marrow of acute leukemia patients. Blood 1993; 82: 914-9.
8. Scherrer A, Wohlwend A, Kruithof EKO, Vassalli J-D, Sappino A-P. Plasminogen activation in human acute leukaemias. Br J Haematol 1999; 105: 920-7.
9. Nusrat AR, Chapman HAJ. An autocrine role for urokinase in phorbol ester-mediated differentiation of myeloid cell lines. J Clin Invest 1991; 87: 1091-7.
10. Devy L, Hullender P, Munaut C, Colige A, Garnotel R, Foidart J-M, Noel A, Jeannesson P. Matrix and serine protease expression during leukemic cell differentiation induced by aclacinomycin and all-transretinoic acid. Biochem Pharmacol 2002; 63: 179-89.
11. Tapiovaara H, Alitalo R, Vaheri A. Plasminogen activation on tumor cell surface and its involvement in human leukemia. Adv Cancer Rex 1996; 69: 101-13.
12. Bene MC, Castoldi G, Knapp W, Rigolin GM, Escribano L, Lemez P, Ludwig W-D, Orfao A, Lanza F, van't Veer M. CD87 (urokinase-type plasminogen activator receptor), function and pathology in hematological disorders: a review. Leukemia 2004; 18: 394-400.
13. Verde P, Boast S, Franze A. Robbiati F, Blasi F. An upstream enhancer and a negative element in the 5′ flanking region of the human urokinase plasminogen activator gene. Nucleic Acids Res 1988; 16: 10699-707.
14. Nerlov C, Rorth P, Blasi F, Johnsen M. Essential AP-1 and PEA3 binding elements in the human urokinase enhancer display cell type-specific activity. Oncogene 1991; 6: 1583-92.
15. Ibanez-Tallon I, Ferrai C, Longobardi E, Facetti I, Blasi F, Crippa MP. Binding of Sp1 to the proximal promoter links constitutive expression of the human uPA gene and invasive potential of PC3 cells. Blood 2002; 100: 3325-32.
16. Suzuki Y, Shimada J, ShudoK, Matsumura M, Crippa MP, Kojima S. Physical interaction between retinoic acid receptor and Sp1: mechanism for induction of urokinase by retinoic acid. Blood 1999; 93: 4264-76.
17. Grimaldi P, Piscitelli D, Albanesi C, Blasi F, Geremia R, Rossi P. Identification of 3′,5′-cyclic adenosine monophosphate-inducible nuclear factors binding to the human urokinase promoter in mouse Sertoli cells. Mol Endocrinol 1993; 7: 1217-25.
18. Lutterbach B, Hiebert SW. Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation. Gene 2000; 245: 223-35.
19. Kurokawa M, Hirai H. Role of AML1/Runx1 in the pathogenesis of hematological malignancies. Cancer Sci 2003; 94: 841-6.
20. Otto F, Lubbert M, Stock M. Upstream and downstream targets of RUNX proteins. J Cell Biochem 2003; 89: 9-18.
21. Coffman JA. Runx transcription factors and the developmental balance between cell proliferation and differentiation. Cell Biol Int 2003; 27: 315-24.
22. Meyers S, Downing JR, Hiebert SW. Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions. Mol Cell Biol 1993; 13: 6336-45.
23. Smicun Y, Kopf E, Miskin R. The 3′-untranslated region of the urokinase gene enhances the expression of chimeric genes in cultured cells and correlates with specific brain expression in transgenic mice. Eur J Biochem 1998; 251: 704-15.
24. Axelrod JH. Human plasminogcn activators: cDNA cloning, effect on tumor growth and metastasis, and study of some regulatory aspects. PhD thesis. The Feinberg Graduate School of the Weizmann Institute of Science, Israel, 1987.
25. Rieder MJ, Carrington DP, Chung M-W, Lee KL, Poel CL, Yi Q, Nickerson DA. SeattleSNPs NHLBI Program for Genomic Applications. (URL: http://pga.mbt. washington.edu) 2001 (GenBank accession number: AF377330).
26. Riccio A, Grimaldi G, Verde P, Sebastio G, Boast S, Blasi F. The human urokinase-plasminogen activator gene and its promoter. Nucleic Acids Rex 1985; 13: 2759-71.
27. Bartoov-Shifman R, Hertz R, Wang H, Wollheim CB, Bar-Tana J, Walker MD. Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4 alpha. J Biol Chem 2002; 277: 25914-9.
28. Schreiber E, Matthias P, Müller MM, Schaffner W. Rapid detection of octamer binding proteins with 'mini-extracts' prepared from a small number of cells. Nucleic Acids Res 1989; 17: 6419.
29. Liu P, Tarle SA, Hajra A, Claxton DF, Marlton P, Freedman M, Siciliano MJ, Collins FS. Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Science 1993; 261: 1041-4.
30. Tkachuk DC, Kohler S, Cleary ML. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 1992; 71: 691-700.
31. Rubnitz JE, Morrissey J, Savage PA, Cleary ML. ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells. Blood 1994; 84: 1747-52.
32. Ben-Yosef T, Yanuka O, Benvenisty N. ECA39 is regulated by c-Myc in human and by a Jun/Fox homolog, Gcn4, in yeast. Oncogene 1996; 13: 1859-66.
33. Ronen D, Rotter V, Reisman D. Expression from the murine p53 promoter is mediated by factor binding to a downstream helix-loop-helix recognition motif. Proc Natl Acad Sci USA 1991; 88: 4128-32.
34. Bello-Fernandez C, Packham G, Cleveland JL. The ornithine decarboxylase gene is a transcriptional target of c-Myc. Proc Natl Acad Sci USA 1993; 90: 7804-8.
35. Reddy SY, Obika S, Bruice TC. Conformations and dynamics of Etx-1 ETS domain-DNA complexes. Proc Natl Acad Sci USA 2003; 100: 15475-80.
36. Bennett B, Booth NA, Croll A, Dawson AA. The bleeding disorder in acute promyelocytic leukaemia: fibrinolysis due to u-PA rather than defibrination. Br J Haematol 1989; 71: 511-7.
37. Reiter LS, Spertini O, Kruithof EK. Plasminogen activators play an essential role in extracellular-matrix invasion by lymphoblastic T cells. Int J Cancer 1997; 70: 461-6.
38. Degen SJ, Heckel JL, Reich E, Degen JL. The murine urokinase-type plasminogen activator gene. Biochemistry 1987; 26: 8270-9.