An investigation into the influence of hydrogel composition on swelling behavior and drug release from poly(acrylamide-co-itaconic acid) hydrogels in various media

Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents

Volumn 13, Issue 1, 2006, Pages 1-7

  Stanojević, Marija ^a,b   Krušić, Melina Kalagasidis ^a   Filipović, Jovanka ^a   Parojčić, Jelena ^a   Stupar, Mirjana ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b Faculty of Pharmacy   (Serbia)

Author keywords

Experimental Design; Hydrogels; Paracetamol Release; Swelling

Indexed keywords

ACRYLIC ACID COPOLYMER; PARACETAMOL; POLY(ACRYLAMIDE CO ITACONIC ACID); UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL COMPOSITION; CROSS LINKING; DRUG DETERMINATION; DRUG RELEASE; EXPERIMENTAL DESIGN; HYDROGEL; PH; POLYMERIZATION; PRIORITY JOURNAL; RESPONSE SURFACE METHOD; STATISTICAL ANALYSIS; WETTABILITY;

EID: 30644462189     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.1080/10717540500313034     Document Type: Article

References (31)

1. Alvarez-Lorenzo, C., and Concheiro, A. 2002. Reversible adsorption by a pH- and temperature-sensitive acrylic hydrogel. J. Control. Rel. 80:247-257.
2. Amidon, L. G., and Lobenberg, R. 2000. Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards. Eur. J. Pharm. Biopharm. 50:3-12.
3. Bajpai, S. K. 2001. Swelling-deswelling behavior of poly(acrylamide-co- maleic acid) hydrogels. J. Appl. Polym. Sci. 80:2782-2789.
4. Bajpai, A. K., and Giri, A. 2003. Water sorption behaviour of highly swelling (carboxymethylcellulose-g-polyacrylamide) hydrogels and release of potassium nitrate as agrochemical. Carbo. Polym. 53:271-279.
5. Bernardo, M. V., Blanco, M. D., Olmo, R., and Teijon, J. M. 2002. Delivery of Bupivacaine included in poly(acrylamide-co-monomethyl itaconate) hydrogels as a function of the pH swelling medium. J. Appl. Polym. Sci. 86:327-334.
6. Bettini, R., Colombo, P., and Peppas, N. A. 1995. Solubility effects on drug transport through pH-sensitive, swelling-controlled release systems: transport of theophylline and metoclopramide monohydrochloride. J. Control. Rel.37:105-111.
7. Blanco, M. D., Garcia, O., Trigo, R. M., Teijon, J. M., and Katime, I. 1996. 5-Fluorouracil release from copolymeric hydrogels of itaconic acid monoester. Biomaterials 17:1061-1067.
8. Blanco, M. D., Bernardo, M. V., Teijon, C., Sastre, R. L., and Teijon, J. M. 2003. Transdermal application of bupivacaine-loaded poly(acrylamide-co- monomethyl itaconate) hydrogels. Int. J. Pharm. 255:99-107.
9. Box, G. E. P., Hunter, W. G., and Hunter, J. S. 1978. Statistic for Experimenters. An Introduction to Design, Data Analysis and Model Building. New York: John Wiley & Sons.
10. FDA Guidance for Industry 1997. Dissolution Testing of Immediate Release Solid Oral Dosage Forms. Rockville, MD: Center for Drug Evaluation and Research.
11. Gupta, P., Vermani, K., and Garg, S. 2002. Hydrogels: from controlled release to pH- responsive drug delivery. Drug Dis. Today7:569-579.
12. Hennink, W. E., and van Nostrum, C. F. 2002. Novel crosslinking methods to design hydrogels. Adv. Drug Del. Rev. 54:13-36.
13. Hoffman, A. S. 2002. Hydrogels for biomedical applications. Adv. Drug Del. Rev. 54:3-12.
14. Isik, B. 2004. Swelling behavior and determination of diffusion characteristics of acrylamide-acrylic acid hydrogels. J. Appl. Polym. Sci. 91:1289-1293.
15. Karadag, E., Saraydin, D., and Cetinkaya, S., and Guven, O. 1996. In vitro swelling studies and preliminary biocompatibility evaluation of acrylamide-based hydrogels. Biomaterials 17:67-70.
16. Karadag, E., Saraydin, D., and Guven, O. 2001. Radiation induced superabsorbent hydrogels. Acrylamide/Itaconic acid copolymers. Macromol. Mater. Eng. 286:34-42.
17. Katime, I., Novoa, R., Diaz de Apodaca, E., Mendizabal, E., and Puig, J. 1999. Theophylline release from poly (acrylic acid-co-acrylamide) hydrogels. Polym. Test. 18: 559-566.
18. Kayaman, N., Hamurcu, E. E. G., Uyanik, N., and Baysal, B. M. 1999. Interpenetrating hydrogel networks based on polyacrylamide and poly(itaconic acid): synthesis and characterization. Macromol. Chem. Phys. 200:231-238.
19. Khare, A. R., and Peppas, N. A. 1995. Swelling/deswelling of anionic copolymer gels. Biomaterials 16:559-567.
20. Kirimura, K., Sato, T., Nakanishi, N., Terada, M., and Usami, S. 1997. Breeding of starch-utilizing and itaconic-acid-producing koji molds by interspecific protoplast fusion between Aspergillus terreus and Aspergillus usamii. Appl. Microbiol. Biotechnol. 47:127-131.
21. Montgomery, D. 1997. Design and Analysis of Experiments, 4th ed. New York: John Wiley & Sons.
22. Peppas, N. A. 1985. Analysis of Fickian and non-Fickian drug release from polymers. Pharm. Acta Helv.60:110-111.
23. Peppas, N. A., Bures, P., Leobandung, W., and Ichikawa, H. 2000. Hydrogels in pharmaceutical formulations. Eur. J. Pharm. Biopharm. 50:27-46.
24. Qiu, Y., and Park, K. 2001. Environment-sensitive hydrogels for drug delivery. Adv. Drug Deliv. Rev. 53:321-339.
25. Quaglia, F., Varricchio, G., Miro, A., La Rotonda, M. I., Larobina, D., and Mensitieri, G. 2001. Modulation of drug release from hydrogels by using cyclodextrins: the case of nicardipine/β-cyclodextrin system in crosslinked polyethylenglycol. J. Control. Rel. 71:329-337.
26. Rodriguez, R., Alvarez-Lorenzo, C., and Concheiro, A. 2003. Interactions of ibuprofen with cationic polysaccharides in aqueous dispersions and hydrogels. Rheological and diffusional implications. Eur. J. Pharm. Sci. 20:429-438.
27. Saraydin, D., Karadag, E., Caldiran, Y., and Guven, O. 2001. Nicotine-selective radiation-induced poly(acrylamide/maleic acid) hydrogels. Radiat. Phys. Chem. 60:203-210.
28. Sen, M., Uzun, C., and Guven, O. 2000. Controlled release of terbinafine hydrochloride from pH sensitive poly(acrylamide/maleic acid) hydrogels. Int. J. Pharm. 203: 149-157.
29. Sen, M., and Yakar, A. 2001. Controlled release of antifungal drug terbinafine hydrochloride from poly(N-vinyl 2-pyrrolidone/itaconic acid) hydrogels. Int. J. Pharm. 228:33-41.
30. Wheast, R. C. 1975. Handbook of Chemistry and Physics, 53rd ed. Cleveland, OH: CRC Press.
31. Willke, T., and Vorlop, K. D. 2001. Biotechnological production of itaconic acid. Appl. Microbiol. Biotechnol. 56:289-295.