Effects of water deprivation on the pharmacokinetics of DA-8159, a new erectogenic, in rats

Journal of Pharmacy and Pharmaceutical Sciences

Volumn 9, Issue 1, 2005, Pages 10-21

  Kim, Ji Young ^a   Kim, Yu Chul ^a   Lee, Myung Gull ^a   Kwon, Jong Won ^b   Yoo, Moohi ^b  

^a Seoul National University   (South Korea)

^b Dong A Pharmaceutical Company   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; DA 8164; MESSENGER RNA; PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; UDENAFIL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DEHYDRATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; EXPERIMENTAL MODEL; FIRST PASS EFFECT; INTESTINE; LIVER MICROSOME; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; RAT STRAIN; STATISTICAL SIGNIFICANCE; URINARY EXCRETION; URINE FLOW RATE; URINE VOLUME; WATER DEPRIVATION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; DEHYDRATION; INJECTIONS, INTRAVENOUS; MALE; PHOSPHODIESTERASE INHIBITORS; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; WATER DEPRIVATION;

EID: 30544454802     PISSN: 14821826     EISSN: 14821826     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Shim, H.J., Kim, Y.C., Lee, J.H., Kwon, J.W., Kim, W.B., Kim, Y.G., Kim, S.H., and Lee, M.G.., Interspecies pharmacokinetic scaling of DA-8159, a new erectogenic, in mice, rats, rabbits, and dogs, and prediction of human pharmacokinetics. Biopharm Drug Dispos, 26:269-277, 2005.
2. Doh, H., Shin, C.Y., Son, M., Ko, J.I., Yoo, M., Kim, S.H., and Kim, W.B., Mechanism of erectogenic effect of the selective phosphodiesterase type 5 inhibitor, DA-8159. Arch Pharm Res, 25:873-878, 2002.
3. Ahn, B.O., Kang, K.K., Ahn, G.J., Kwon, J.W., Kim, W.B., Kang, K.S., and Lee, Y.S., Efficacy of DA-8159, a new PDE5 inhibitor, for inducing penile erection in rabbits with acute spinal cord injury. Int J Impot Res, 15:405-411, 2003.
4. Kang, K.K., Ahn, G.J., Ahn, B.O., Yoo, M., and Kim, W.B., DA-8159, a new PDE5 inhibitor, induces penile erection in conscious and acute spinal cord injured rabbits. Eur Urol, 43:689-695, 2003.
5. Kim, Y.C., Shim, H.J., Lee, J.H., Kim, S.H., Kwon, J.W., Kim, W.B., and Lee, M.G.., Effect of enzyme inducers and inhibitors on the pharmacokinetics of intravenous DA-8159, a new erectogenic, in rats. Biopharm Drug Dispos, 26:233-241, 2005.
6. Bakar, S.K., and Niazi, S., Effect of water deprivation on aspirin disposition kinetics. J Pharm Sci, 72:1030-1034, 1983.
7. Huang, J.Y., Kim, O.N., Lee, S.H., and Lee, M.G., Effects of water deprivation on the pharmacokinetics and pharmacodynamics of bumetanide in rats. Biopharm Drug Dispos, 14:463-474, 1993.
8. Ha, H.A., Lee, S.H., Kim, S.H., Kim, O.N., and Lee, M.G., Effect of water deprivation for 48 hours on the pharmacokinetics and pharmacodynamics of azosemide in rats. Res Commun Mol Pathol Pharmacol, 93:109-128, 1996.
9. Son, I.J., Moon, Y.J., Lee, M.G., and Sohn YT. No effect of water deprivation for 48 hours on the pharmacokinetics of intravenous tacrolimus in rats. Res Commun Mol Pathol Pharmacol, 107:279-289, 2000.
10. Kim, S.H., Kwon, J.W., Kim, W.B., Lee, I., and Lee, M.G. Effects of water deprivation for 72 hours on the pharmacokinetics of a new carbapenem, DA-1131, in rats. Life Sci, 71:2291-2298, 2002.
11. Kim, Y.C., Kim, Y.G., Kim, E.J., Cho, M.K., Kim, S.G., and Lee MG., Pharmacokinetics of intravenous chlorzoxazone in rats with dehydration and rehydration: Effects of food intakes. Biopharm Drug Dispos, 24:53-61, 2003.
12. Kim, S.G., Kim, E.J., Kim Y.G., and Lee, M.G., Expression of cytochrome P-450s and glutathione S-transferases in the rat liver during water deprivation: Effects of glucose supplementation. J Appl Toxicol, 21:123-129, 2001.
13. Bae, S.K., Lee, S.J., Kim, J.W., Kim, Y.H., Kim, S.G., and Lee, M.G., Pharmacokinetics of oltipraz after intravenous and oral administration in rats with dehydration for 72 hours. Biopharm Drug Dispos, 26:77-83, 2005.
14. Bradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem, 72:248-254, 1976.
15. Shim, H.J., Lee, E.J., Jung, Y.H., Kim, S.H., Kim, S.H., Yoo, M., Kwon, J.W., Kim, W.B., and Lee, M.G., Determination of a new phosphodiesterase V inhibitor, DA-8159, in plasma and urine by high-performance liquid chromatography. J Pharm Biomed Anal, 30:527-533, 2002.
16. Lineweaver, H., and Burk, D., The determination of enzyme dissociation constants. J Am Chem Soc, 56:658-666, 1934.
17. Kim, S.H., Choi, Y.M., and Lee, M.G., Pharmacokinetics and pharmacodynamics of furosemide in protein-calorie malnutrition. J Pharmacokinet Biopharm, 21:1-17, 1993.
18. Shim, H.J., Kim, Y.C., Park, K.J., Kim, D.S., Kwon, J.W., Kim, W.B., and Lee, M.G., Pharmacokinetics of DA-8159, a new erectogenic, after intravenous and oral administration to rats: Hepatic and intestinal first-pass effects. J Pharm Sci, 92:2185-2195, 2003.
19. Shim, H.J., Lee, E.J., Kim, S.H., Kim, S.H., Yoo, M., Kwon, J.W., Kim, W.B., and Lee, M.G., Factors influencing the protein binding of a new phosphodiesterase V inhibitor, DA-8159, using an equilibrium dialysis technique. Biopharm Drug Dispos, 21:285-291, 2000.
20. Chiou, W.L., Critical evaluation of potential error in pharmacokinetic studies using the linear trapezoidal rule method for the calculation of the area under the plasma level-time curve. J Pharmacokinet Biopharm, 6:539-546, 1978.
21. Gibaldi, M., and Perrier, D., Pharmacokinetics. 2nd ed. Marcel-Decker, New York, NY, USA, 1982.
22. Chiou, W.L., New calculation method for mean apparent drug volume of distribution and application to rational dosage regimens. J Pharm Sci, 68:1067-1069, 1979.
23. Eatman, F.B., Colburn, W.A., Boxenbaum, H.G., Posmanter, H.N., Weinfeld, R.E., Ronfeld, R., Weissman, L., Moore, J.D., Gibaldi, M., and Kaplan, S.A., Pharmacokinetics of diazepam following multiple-dose oral administration to healthy human subjects. J Pharmacokinet Biopharm, 5:481-494, 1977.
24. Chiou, W.L., New calculation method of mean total body clearance of drugs and its application to dosage regimens. J Pharm Sci, 69:90-91, 1980.
25. Shim, H.J., Lee, E.J., Kim, S.H., Kim, S.H., Yoo, M., Kwon, J.W., Kim, W.B., Lee, H.S., and Lee, M.G., Pharmacokinetics, stability, and blood partition of DA-8159, a new phosphodiesterase V inhibitor. Res Commun Mol Pathol Pharmacol, 108:275-286, 2000.
26. Kim, Y.C., Kwon, J.W., Kim, W.B., Lee, I., and Lee, M.G., Pharmacokinetic changes of intravenous DA-8159, a new erectogenic, in rat with diabetes mellitus induced by streptozotocin. J Pharm Sci, 93:2374-2387, 2004.
27. Lee, M.G., and Chiou, W.L., Evaluation of potential causes for the incomplete bioavailability of furosemide: Gastric first-pass metabolism. J Pharmacokinet Biopharm, 11:623-640, 1983.
28. Kutscher, C.L., Hematocrit, plasma osmolality, and plasma protein concentration as estimators of plasma volume in hooded rats during food and water deprivation. Physiol Behav, 7:283-285, 1971.
29. LeCompte, J., Dumont, L., Hill, J., du Souich, P., and Lelorier, J., Effect of water deprivation and rehydration on gentamicin disposition in the rat. J Pharmacol Exp Ther, 218:231-236, 1981.
30. Hope, A., and Tyssebotn, I., The effect of water deprivation on local renal blood flow and filtration in the laboratory rat. Circ Shock, 11:175-186, 1983.
31. Lee, H.J., and Chiou, W.L., Erythrocytes as barriers for drug elimination in the isolated rat liver. I. Doxorubicin. Pharm Res, 6:833-839, 1989.
32. Lee, H.J., and Chiou, W.L., Erythrocytes as barriers for drug elimination in the isolated rat liver. II. Propranolol. Pharm Res, 6:840-843, 1989.