Glibenclamide depletes ATP in renal proximal tubular cells by interfering with mitochondrial metabolism

British Journal of Pharmacology

Volumn 145, Issue 8, 2005, Pages 1069-1075

  Engbersen, Richard ^a   Masereeuw, Rosalinde ^a   Van Gestel, Miriam A ^a   Van Der Logt, Elise M J ^a   Smits, Paul ^a   Russel, Frans G M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

ATP; ATP sensitive potassium channels; Glibenclamide; Glyburide; Kidney; Mitochondria; Oxidative phosphorylation; Proximal tubules; Sulfonylurea drugs; Uncoupling

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; GLIBENCLAMIDE; OXYGEN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; DRUG INHIBITION; DRUG MECHANISM; ENERGY METABOLISM; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENERGY METABOLISM; GLYBURIDE; HYPOGLYCEMIC AGENTS; KIDNEY TUBULES, PROXIMAL; MALE; MITOCHONDRIA; OXYGEN CONSUMPTION; POTASSIUM CHANNELS; RATS; RATS, WISTAR;

EID: 30544452817     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706275     Document Type: Article

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