Current diagnosis and treatment of Lyme disease

Comprehensive Therapy

Volumn 31, Issue 4, 2005, Pages 284-290

  Smith, Robert P ^a  

^a Maine Medical Center Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACARICIDE; AMOXICILLIN; ANTIBIOTIC AGENT; CEFTRIAXONE; CEFUROXIME; DOXYCYCLINE; MACROLIDE; VACCINE;

CLINICAL FEATURE; HUMAN; LYME DISEASE; PATHOGENESIS; REVIEW; SEROLOGY; SYMPTOM;

ANTI-BACTERIAL AGENTS; DISEASE PROGRESSION; DOXYCYCLINE; ERYTHEMA CHRONICUM MIGRANS; HUMANS; LYME DISEASE; SEROLOGIC TESTS;

EID: 30444457075     PISSN: 00988243     EISSN: None     Source Type: Journal    
DOI: 10.1385/COMP:31:4:284     Document Type: Review

References (48)

1. Steere AC. Lyme disease. N Engl J Med, 2001;345:115-124.
2. Steere AC, Coburn J, Glickstein L. The emergence of Lyme disease. J Clin Invest 2004;113:1093-1101.
3. Cooper, JD, Feder MH Jr. Inaccurate information about Lyme disease on the internet. Pediatr Infect Dis J 2004;23:1105-1108.
4. Schwan, TG, Piesman J, Golde, WT, et al. Induction of an outer surface protein on Borrelia burgdorferi during tick feeding. Proc Natl Acad Sci USA 1995;92:2909-2913.
5. Zhao, Z, Chang H, Trevino RP, et al. Selective up-regulation of matrix metalloproteinase-9 expression in human erythema migrans skin lesions of acute Lyme disease. J Infect Dis 2003;188:1098-1104
6. Wormser, GP, McKenna D, Carlin J, et al. Brief communication: Hematogenous dissemination in early Lyme disease. Ann Intern Med 2005;142:751-755.
7. Lusitani, D, Malawista SE, Montgomery, RR. Borrelia burgdorferi are susceptible to killing by a variety of human polymorphonuclear leukocyte components. J Infect Dis 2002;185:797-804.
8. Kalish, RA, McHugh G, Granquist J, et al. Persistence of immunoglobulin M or immunoglobulin G antibody responses to Borrelia burgdorferi 10-20 years after active Lyme disease. Clin Infec Dis 2001;33:780-785.
9. Gerber MA, Shapiro Ed, Burke GS, et al. Lyme disease in children in southern Connecticut. Pediatric Lyme Disease Study Group. N Eng J Med 1996;335:1270-1274.
10. Steere AC, Sikand VK, Meurice F, et al. Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. N Engl J Med 1998;339:209-215.
11. Nadelman RB, Nowakowski J, Forester, Gilda, et al. The clinical spectrum of early Lyme borreliosis in patients with culture-confirmed erythema migrans. Am J Med 1996;100:502-508.
12. Smith RP, Schoen RT, Rahn DW, et al. Clinical characteristics and treatment outcome of early Lyme disease in patients with microbiologically confirmed erythema migrans. Ann Intern Med 2002;136:421-428.
13. Steere AC, Barthenhagen NH, Craft JE, et al. The early clinical manifestations of Lyme disease. Ann Intern Med 1983;9:76-82.
14. Campbell GL, Paul WS, Schriefer ME, Craven RB, Robbins KE, Dennis DT. Epidemiologic and diagnostic studies of patients with suspected early Lyme disease in Missouri. J Infect Dis 1995;272:470-480.
15. Wormser GP, Masters E, Liveris D, et al. Microbiologic evaluation of patients from Missouri with erythema migrans. Clin Infect Dis 2005;40:423-428.
16. Steere AC, Hernandez J, Sikand VK, Nowakowski J, Persing DH. Systemic symptoms without erythema migrans as the presenting picture of early Lyme disease. Am J Med 2003;114:58-61.
17. Steere AC, Sikand VK, Schoen RT, Nowakowski J. Asymptomatic infection with Borrelia burgdorferi. Clin Infec Dis 2003;37:528-532.
18. Steere AC, Batsford WP, Weinberg M, et al. Lyme carditis: cardiac abnormalities of Lyme disease. Ann Intern Med 1980;93(part1):8-16.
19. McAlister HF, Klementowicz PT, Andrews C, et al. Lyme carditis: an important cause of reversible heart block. Ann Intern Med 1989;110:339-345.
20. Sangha O, Phillips CB, Fleischmann KE, et al. Lack of cardiac manifestations among patients with previously treated Lyme disease. Ann Intern Med. 1998;128:346-353.
21. Steere AC, Glickstein L. Elucidation of Lyme arthritis. Immunology 2004;4:143-152.
22. Reik L, Steere AC, Bartengagen NH, Shope RE, Malawista SE. Neurologic abnormalities of Lyme disease. Medicine (Baltimore) 1979;58:281-294.
23. Halpern J, Little BW, Coyle PK, Dattwyler RS. Lyme disease: cause of a peripheral neuropathy. Neurology 1986;37:1700-1706.
24. Logigian EL, Kaplan RF, Steere AC. Chronic neurologic manifestations of Lyme disease. N Eng J Med 1990;323:1438-1444.
25. Thompson C, Spielman A, Krause PJ. Coinfecting deer-associated zoonoses: Lyme disease, babesiosis, and ehrlichiosis. Clin Infec Dis 2001;33:676-684.
26. Recommendations for test performance and interpretation from the Second National Conference on Serologic Diagnosis of Lyme disease. MMWR Morb Mortal Wkly Rep 1995;44:596-601.
27. Bakken Li, Callister SM, Ward PJ, et al. Interlaboratory comparison of test results for detection of Lyme disease by 516 participants in the Wisconsin State Laboratory of Hygiene/College of American Pathologists Proficiency Testing Program. J Clin Microbiol 1997;35:537-543.
28. Bacon RM, Biggerstaff BJ, Schriefer ME, et al. Serodiagnosis of Lyme disease by kinetic enzyme-linked immunosorbent assay using recombinant VlsE1 or peptide antigens of Borrelia burgdorferi compared with 2-tiered testing using whole-cell lysates. J Infect Dis 2003;186:1187-1198.
29. Mogilyansky E, Loa CC, Adelson ME, Mordechai E, Tilton RC. Comparison of western immunoblotting and the C6 Lyme antibody test for laboratory detection of Lyme disease. CDLI 2004;11.5:924-929.
30. Steere AC, Taylor E, Wilson ML, Levine JF, Spielman A. Longitudinal assessment of the clinical and epidemiological features of Lyme disease in a defined population. J Infec Dis 1986;154:295-300.
31. Notice to readers: caution regarding testing for Lyme disease. MMWR Morb Mortal Wkly Rep 2005;54:125
32. Wormser GP, Nadelman RB, Dattwyler RJ, et al. Practice guidelines for the treatment of Lyme disease. Clin Infec Dis 2000;31(Suppl 1):S1-S14.
33. Wormser GP, Ramanthan R, Nowakowski J, et al. Duration of antibiotic therapy for early Lyme disease. Ann Intern Med 2003;138:697-704.
34. Luger SW, Paparone P, Wormser GP, et al. Comparison of cefuroxime axetil and doxycycline in treatment of patients with early Lyme disease associated with erythema migrans. Am Soc Microb 1995;39:661-667.
35. Nadelman RB, Luger SW, Frank E, et al. Comparison of cefuroxime axetil and doxycycline in the treatment of early Lyme disease. Ann Intern Med 1992;1176:273-280.
36. Dattwyler RJ, Luft BJ, Kunkel MJ, et al. Cefriaxone compared with doxycycline for the treatment of acute disseminated Lyme disease. N Eng J Med 1997;337:289-294
37. Dovevall L, Hagberg L. Successful oral doxycycline treatment of Lyme disease-associated facial palsy and meningitis. Clin Infec Dis 1999;28:569-574.
38. Logigian EL, Kaplan RF, Steere AC. Successful treatment of Lyme encephalopathy with intravenous ceftriaxone. J Infec Dis 1999;180:377-383.
39. Klempner MS, Linden MD, Hu T, et al. Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease. N Engl J Med 2001;345:85-92.
40. Krupp LB, Hyman LG, Grimson R, et al. Study and treatment of post Lyme disease (STOP-LD). Neurology 2003;60:1923-1930.
41. Klempner MS. Controlled trials of antibiotic treatment in patients with post-treatment chronic Lyme disease. Vector Borne and Zoonotic Dis 2002:2:255-263.
42. Seltzer, EG, Gerber MA, Cartter ML, Freudigman K, Shapiro ED. Long-term outcomes of persons with Lyme disease. JAMA 2000;283:609-615.
43. Shadick NA, Phillips CB, Sangha O, et al. Musculoskeletal and neurologic outcomes in patients with previously treated Lyme disease. Ann Intern Med. 1999;131:919-926.
44. Nowakowski J, Nadelman RB, Sell, R, et al. Long-term follow-up of patients with culture-confirmed Lyme disease. Am J Med. 2003;115:91-96.
45. Kalish, RA, Kaplan RF, Taylor E, Jones-Woodward L, Workman K, Steere AC. Evaluation of study patients with Lyme disease, 10-20-year follow-up. J Infec Dis 2001;183:453-460.
46. Hayes EB, Piesman J. How can we prevent Lyme disease? N Engl J Med 348:2424-2430.
47. Nadelman RB, Nowakowski J, Fish D, et al. Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. N Engl J Med 2001;345:79-84.
48. Smith RP. Tick-borne infections. In: Medical Management of Infectious Disease (Grace C ed.). Marcel Dekker, New York, 2003, pp. 606-607.