Condensed naphtho[1,8-de][1,3]thiazines 2. An orientating structure modification of naphtho[1,8-de][1,2,4]-triazolo[3,4-b][1,3]thiazine ring system

Chinese Pharmaceutical Journal

Volumn 57, Issue 1, 2005, Pages 43-48

  Hsu, Wen Chuan ^a   Tao, Tung Mei ^a   Liu, Kang Chien ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Inhibitors of platelet aggregation; Methyl naphtho 1,8 de 1,3 thiazin 2 ylhydrazonopyruvate; Naphtho 1,8 de tetrazolo 5,1 b 1,3 thiazine; Naphtho 1,8 de 1,2,4 triazolo 3,4 b 1,3 thiazine

Indexed keywords

2 HYDRAZINO[1,8 DE][1,3]THIAZINE; ACETIC ACID; ANTITHROMBOCYTIC AGENT; METHYL NAPHTHO[1,8 DE][1,3]THIAZIN 2 YLHYDRAZONOPYRUVATE; NAPHTHO[1,8 DE]TETRAZOLO[5,1 B][1,3]THIAZINE; PYRUVIC ACID; SODIUM NITRITE; THIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; RING CLOSING METATHESIS;

EID: 30444448081     PISSN: 10161015     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Hsu, W. C.; Tao, T. M.; Chou, T. C.; Ding, Y. A.; Liu, K. C. Condensed Naphtho[1,8-de][1,3]-thiazines 1. Synthesis of Naphtho[1,8-de][1,2,4]triazolo[3, 4-b][1,3]thiazine Derivatives and Their Inhibitory Activity on Human Platelet Aggregation. Chin. Pharm. J. 2002, 54, 331-352.
2. Liu, K. C.; Hu, M. K. Synthesis and Antihypertensive Activity of 2-Imino-2,3-dihydro-5H-1,3,4-thiadiazolo[2,3-b]quinazolin-5-ones. Arch. Pharm. (Weinheim) 1987, 320, 166-171.
3. Liu, K. C.; Hu, M. K. Synthesis and Antibacterial Activity of 2-Amino-7-chloro-5H-[1,3,4]thiadiazolo[2,3-b]quinazolin-5-one. J. Taiwan Pharm. Assoc. 1987, 39, 204-206.
4. Liu, K. C.; Chen, C. A One-Pot Synthesis of 2-Mercapto-5H-[1,3,4] thiadiazolo[2,3-b]quinazolin-5-one. Chin. Pharm. J. 1990, 42, 277-280.
5. Liu, K. C.; Chen, C.; Hu, M. K. Synthesis and Biological Evaluation of 2-Substituted 1,3,4-Thiadiazolo[2,3-b]quinazolin-5-ones. Chin. Pharm. J. 1995, 47, 253-262.
6. Liu, K. C. Heterocycles with Built-in Pseudothiourea Pharmacophore I. Condensed Naphtho[1,2-d]thiazole Derivatives. Chin. Pharm. J. 1995, 47, 273-293.
7. Hsu, L. Y.; Hu, M. K.; Liu, K. C. Heterocycles with Built-in Pseudothiourea Pharmacophores 2. Synthesis and Biological Activities of Thiazole- and [1,3]Thiazine-fused Benzimidazoles, Quinazolines and Perimidines. Chin. Pharm. J. 2003, 55, 153-168.
8. Samuelsson, B.; Goldyne, M.; Granstrom, E.; Hamberg, M.; Hammarstrom, S.; Malmsten, C. Prostaglandins and Thromboxanes. Ann. Rev. Biochem. 1978, 47, 997-1029.
9. Guerret, P.; Jacquier, R.; Maury, G. An Investigation of the Minimal Structural Conditions for the Dimroth-Type Rearrangement in the Polyazaindolizine Series. J. Heterocycl. Chem. 1971, 8, 643-650.
10. Shishoo, C. J.; Devani, M. B.; Ullas, G. V.; Ananthan, S.; Bhadti, V. S. Studies in the Synthesis and Interconversion of Isomeric Triazolothienopyrimidines. J. Heterocycl. Chem. 1981, 18, 43-46.
11. Murdoch, R.; Tully, W. R.; Westwood, R. Synthesis of [1,2,4] Triazoloquinazolinones and Imidazoquinazolinones. J. Heterocycl. Chem. 1986, 23, 833-841.
12. Liu, K. C.; Shih, B. J.; Chern, J. W. Condensed 1,3-Benzothiazinones. 3. Synthesis of 3-Substituted 1,2,4-Triazolo[3,4-b][1,3]benzothiazin-5-ones. J. Heterocycl. Chem. 1990, 27, 391-395.
13. Hu, M. K.; Hsu, L. Y.; Liu, K. C. Guanidine-annelated Heterocycles XIII. Synthesis and Antineoplastic Evaluation of Some 2-Substituted 3H-1,2,4-Triazolo[5,1-b]quinazolin-9-ones. Chin. Pharm. J. 1991, 43, 151-158.
14. Liu, K. C.; Shih, B. J.; Tao, T. M. Condensed 1,3-Benzothiazinones 5. Synthesis of 2-Substituted 3H,10H-[1,2,4]Triazino[6,1-b][1,3] benzothiazin-3,10-diones. Chin. Pharm. J. 1993, 45, 89-94.
15. Hsu, W. C.; Hwang, J. M.; Hsu, L. Y.; Huang, Y. Y.; Liu, K. C. Guanidine-annelated Heterocycles XV. Synthesis of 2-Substituted 4-Phenylamino[1,2,4]triazolo[2,3-a]quinazolin-5(4H)-ones as Potential Antihypertensive Agents. Chin. Pharm. J. 2003, 55(3), 185-196.