Kinetics of MRI contrast agents with a size ranging between Gd-DTPA and albumin-Gd-DTPA: Use of cascade-Gd-DTPA-24 polymer

Electromagnetic Biology and Medicine

Volumn 17, Issue 2, 1998, Pages 283-297

  Demsar, Franci ^a,b   Shames, David M ^a   Roberts, Timothy P L ^a   Stiskal, Michael ^a   Roberts, Heidi C ^a   Brasch, Robert C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

MRI macromolecular contrast agents

Indexed keywords

EID: 3042990628     PISSN: 15368378     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Brasch, R.C., Weinmann, H.-J., and Wesbey, G.E.: Contrast-enhanced NMR imaging: animal studies using gadolinium-DTPA complex, Am. J. Roentgenol. 142, 625-630, 1984.
2. Ogan, M.D., Schmiedl, U., Moseley, M.E., Grodd, W., Paajanen, H., and Brasch, R.C.: Albumin labeled with Gd-DTPA: an intravascular contrast enhancing agent for magnetic resonance blood pool imaging: preparation and characterization, Invest. Radiol. 22, 665-671, 1987.
3. Schmiedl, U., Ogan, M.D., Paajanen, H., Marotti, M., Crooks, L.E., Brito, A.C., and Brasch, R.C.: Albumin labeled with Gd-DTPA as an intravascular, blood pool-enhancing agent for MR imaging: biodistribution and imaging studies, Radiology 162, 205-210, 1987.
4. Kuwatsuru, R., Shames, D., Mühler, A., Mintorowich, J., Vexler, V., Mann, J.S., Huberty, J., and Brasch, R.C.: Quantification of tissue plasma volume in the rat by contrast-enhanced magnetic resonance imaging, Mag. Reson. Med. 30, 76-81, 1993.
5. Shames, D., Kuwatsuru, R., Vexler, V., Muehler, A., and Brasch, R.: Measurement of capillary permeability to macromolecules by dynamic magnetic resonance imaging: a quantitative non-invasive technique, Mag. Reson. Med. 29, 616-622, 1993.
6. Tofts, P.S., and Kermode, A.G.: Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts, Mag. Reson. Med. 17, 357-367, 1991.
7. Tofts, P.S., Berkowitz, B., and Schnall, M.D.: Quantitative analysis of dynamic Gd-DTPA enhancement in breast tumors using a permeability model, Mag. Reson. Med. 33, 564-568, 1995.
8. Hilf, R., Freeman, J.J., Michel, I., and Borman, A.: Characterisation of a transplantable lactating mammary tumor: endocrinological, morphological, and biochemical aspects, Cancer Res. 24, 812-823, 1963.
9. Brasch, R.C., Weinmann, H.J., and Wesbey, G.E.: Contrast-enhanced NMR imaging: animal studies using gadolinium-DTPA complex, Am. J. Roentgenol. 142, 625-630, 1984.
10. White, D., Wang, S.-C., Aicher, K., Dupon, J., Engelstad, B., and Brasch, R.: Albumin-(DTPA-Gd)15-20: Whole body clearance, and organ distribution of gadolinium. Society of Magnetic Resonance in Medicine, 8th Annual Meeting, Aug. 12-18, 1989, Amsterdam, 1, 807, 1989.
11. Schmiedl, U., Ogan, M.D., Moseley, M.E., and Brasch, R.C.: Comparison of the contrast-enhancing properties of albumin-(Gd-DTPA) and Gd-DTPA at 2.0 T: an experimental study in rats, AJR 147, 1263-1270, 1986.
12. Demsar, F., Roberts, T.P., Schwickert, H.C., Shames, D.M., van Dijke, C.F., Mann, J.S., Saeed, M., and Brasch, R.C.: An MRI spatial mapping technique for microvascular permeability and blood volume based on macromolecular contrast agent distribution, Magn. Reson. Med. 37, 236-242, 1996.