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Volumn 21, Issue 6, 2004, Pages 996-999

In vitro and in vivo trans-esterification of 1-[2(R)-(2-amino-2- methylpropionylamino)-3-(1H-indol-3-yl)-propionyl]3(S)-benzyl-piperidine-3- carboxylic acid ethyl ester and the effects of ethanol on its pharmacokinetics in rats

Author keywords

ester drugs; ethanol; growth hormone secretagogue; pharmacokinetics; trans esterification

Indexed keywords

1 [(2 AMINO 2 METHYLPROPIONYLAMINO) 3 (1H INDOL 3 YL)PROPIONYL] BENZYLPIPERIDINE 3 CARBOXYLIC ACID ETHYL ESTER; ALCOHOL; CARBOXYLIC ACID DERIVATIVE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 3042848723     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:PHAM.0000029289.95033.b9     Document Type: Article
Times cited : (4)

References (8)
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    • L. Yang, G. Morriello, A. Patchett, K. Leung, T. Jacks, K. Cheng, K. D. Schleim, W. Feeney, W. W. S. Chan, S. H. L. Chiu, and R. G. Smith. 1-[2(R)-(2-amino-2- methylpropionylamino)-3-(1H-indol-3-yl)propionyl]-3- benzylpiperidine-3(S)- carboxylic acid ethyl ester L-163540: A potent, orally bioavailable, and short-duration growth hormone secretagogue. J. Med. Chem. 41:2439-2441 (1998).
    • (1998) J. Med. Chem. , vol.41 , pp. 2439-2441
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  • 2
    • 0025955766 scopus 로고
    • Human liver cocaine esterase ethanol mediated formation of cocaethylene from alcohol and cocaine
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    • Dean, R.A.1    Christian, C.D.2    Sample, G.H.B.3    Bosron, W.F.4
  • 3
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    • Enzymatic basis for the transesterification of cocaine in the presence of ethanol: Evidence for the participation of microsomal carboxylesterases
    • C. S. Boyer and D. R. Petersen. Enzymatic basis for the transesterification of cocaine in the presence of ethanol: Evidence for the participation of microsomal carboxylesterases. J. Pharmacol. Exp. Ther. 260:939-946 (1996).
    • (1996) J. Pharmacol. Exp. Ther. , vol.260 , pp. 939-946
    • Boyer, C.S.1    Petersen, D.R.2
  • 4
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    • Purification and characterization of human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine
    • M. R. Brzenzinski, T. L. Abraham, C. L. Stone, R. A. Dean, and W. F. Bosron. Purification and characterization of human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine. Biochem. Pharmacol. 48:1747-1755 (1994).
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 1747-1755
    • Brzenzinski, M.R.1    Abraham, T.L.2    Stone, C.L.3    Dean, R.A.4    Bosron, W.F.5
  • 7
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    • Sex-and dose-dependent effects of neonatally administered aspartate on the ultradian patterns of circulating growth hormone regulating hexobarbital metabolism and action
    • A. K. Agrawal, N. A. Pampori, and B. H. Shapiro. Sex-and dose-dependent effects of neonatally administered aspartate on the ultradian patterns of circulating growth hormone regulating hexobarbital metabolism and action. Toxicol. Appl. Pharmacol. 108:96-106 (1991).
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  • 8
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    • Walsh, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.