Is central nervous system processing altered in patients with heart failure?

European Heart Journal

Volumn 25, Issue 11, 2004, Pages 952-962

  Rosen, Stuart D ^a,b   Murphy, Kevin ^c   Leff, Alexander P ^b   Cunningham, Vincent ^b   Wise, Richard J S ^b   Adams, Lewis ^c   Coats, Andrew J S ^a   Camici, Paolo G ^b  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

^b MRC CLINICAL SCIENCES CENTRE   (United Kingdom)

^c CHARING CROSS HOSPITAL   (United Kingdom)

Author keywords

Autonomic nervous system; Brain; Breathlessness; Cerebral blood flow; Exercise; Heart failure; Positron emission tomography

Indexed keywords

ADULT; AGED; ARTICLE; BICYCLE; BICYCLE ERGOMETRY; BLOOD FLOWMETRY; BRAIN BLOOD FLOW; CENTRAL NERVOUS SYSTEM; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DYNAMIC EXERCISE; DYSPNEA; EXERCISE TEST; HEART FAILURE; HUMAN; HYPERVENTILATION; MALE; NERVOUS SYSTEM FUNCTION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REST; VISUAL ANALOG SCALE;

AGED; CARDIAC OUTPUT, LOW; CENTRAL NERVOUS SYSTEM DISEASES; CEREBROVASCULAR CIRCULATION; DYSPNEA; EXERCISE; HUMANS; HYPERVENTILATION; MALE; MIDDLE AGED; PERCEPTION; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 3042828995     PISSN: 0195668X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ehj.2004.03.025     Document Type: Article

References (51)

1. Alexander R.W. Dyspnea and fatigue. Schlant R.C., Alexander R.W. The heart, arteries and veins. eighth ed. 1994;469-474 McGraw-Hill, New York
2. Coats A.J.S. What causes the symptoms of heart failure? Heart. 86:2001;574-578
3. Weber K.T., Kinasewitz G.T., Janicki J.S., et al. Oxygen utilisation and ventilation during exercise in patients with chronic heart failure. Circulation. 65:1982;1213-1223
4. Buller N.P., Poole-Wilson P.A. Mechanism of the increased ventilatory response to exercise in patients with chronic heart failure. Br. Heart J. 63:1990;281-283
5. Davies S.W., Emery T.M., Watlng M.I.L., et al. A critical threshold of exercise capacity in the ventilatory response to exercise in heart failure. Br. Heart J. 65:1991;179-183
6. Chua T.P., Ponikowski P., Harrington D., et al. Clinical correlates and prognostic significance of the ventilatory response to exercise in chronic heart failure. J. Am. Coll. Cardiol. 29:1997;1585-1590
7. Clark A.L., Poole-Wilson P.A., Coats A.J.S. Exercise limitation in chronic heart failure: central role of the periphery. J. Am. Coll. Cardiol. 28:1996;1092-1102
8. Ponikowski P., Chua T.P., Piepoli M., et al. Augmented peripheral chemosensitivity as a potential input to baroreflex impairment and autonomic imbalance in chronic heart failure. Circulation. 96:1997;2586-2594
9. Eckberg D.L., Drabinsky M., Braunwald E. Defective cardiac parasympathetic control in patients with heart disease. N. Engl. J. Med. 285:1971;877-883
10. Binkley P.F., Nunziata E., Haas G.J., et al. Parasympathetic withdrawal is an integral component of autonomic imbalance in congestive heart failure: demonstration in human subjects and verification in a paced canine model. J. Am. Coll. Cardiol. 18:1991;464-472
11. Guzzetti S., Cogliati C., Turiel M., et al. Sympathetic predominance followed by functional denervation in the progression of chronic heart failure. Eur. Heart J. 16:1995;1100-1107
12. Chua T.P., Harrington D., Ponikowski P., et al. Effects of dihydrocodeine on chemosensitivity and exercise tolerance in patients with chronic heart failure. J. Am. Coll. Cardiol. 29:1997;147-152
13. Wilson J.R., Rayos G., Yeoh T.K., et al. Dissociation between exertional symptoms and circulatory function in patients with heart failure. Circulation. 92:1995;47-53
14. Rihal C.S., Nishimura R.A., Hatle L.K., et al. Systolic and diastolic dysfunction in patients with clinical diagnosis of dilated cardiomyopathy. Relation to symptoms and prognosis. Circulation. 90:1994;2772-2779
15. Colebatch J.G., Adams L., Murphy K., et al. Regional cerebral blood flow during volitional breathing in man. J. Physiol. 443:1991;91-103
16. Ramsay S.C., Adams L., Murphy K., et al. Regional cerebral blood flow during volitional expiration in man: a comparison with volitional inspiration. J. Physiol. 461:1993;85-101
17. Fink G.R., Adams L., Watson J.D.G., et al. Hyperpnoea during and immediately after exercise in man: evidence of motor cortical involvement. J. Physiol. 489:1995;663-675
18. 2-stimulated breathing in man. J. Physiol. 488:1995;77-84
19. Williamson J.W., McColl R., Mathews D., et al. Activation of the insular cortex is affected by the intensity of exercise. J. Appl. Physiol. 87:1999;1213-1219
20. Banzett R.B., Mulnier H.E., Murphy K., et al. Breathlessness in humans activates insular cortex. Neuroreport. 11:2000;2117-2120
21. Peiffer C., Poline J.P., Thivard L., et al. Neural substrates for the perception of acutely induced dyspnea. Am. J. Respir. Crit. Care Med. 163:2001;951-957
22. Harper R.M. Visualization of neural activity associated with dyspnea. Am. J. Respir. Crit. Care Med. 163:2001;805-806
23. Williamson J.W., McColl R., Mathews D., et al. Hypnotic manipulation of effort sense during dynamic exercise: cardiovascular responses and brain activation. J. Appl. Physiol. 90:2001;1392-1399
24. Isaev G., Murphy K., Guz A., et al. Areas of the brain concerned with ventilatory load compensation in awake man. J. Physiol. 539:2002;935-945
25. Fox P.T., Raichle M.E., Mintun M.A., et al. Non-oxidative glucose consumption during focal physiologic neural activity. Science. 241:1988;462-464
26. Raichle M. Circulatory and metabolic correlates of brain function in normal humans. Mountcastle V.B., Plum F., Geiger S.R. Handbook of physiology. 1987;643-674 American Physiological Society, Bethesda, MD, USA
27. Mata M., Fink D.G., Ganier H., et al. Activity-dependent energy metabolism in rat posterior pituitary primarily reflects sodium pump activity. J. Neurochem. 34:1980;213-215
28. Friston K.J., Frackowiak R.S.J. Imaging functional anatomy. Lassen N.A., Ingvar D.H., Raichle M.E., et al. Brain work and mental activity. Vol 31:1991;267-279 Alfred Benzon symposium, Copenhagen, Munksgaard
29. Rosen S.D., Paulesu E., Nihoyannopoulos P., et al. Silent ischaemia as a central problem: regional brain activation compared in silent and painful myocardial ischaemia. Ann. Int. Med. 124:1996;939-949
30. Borg G.A.V. Psychophysical bases of perceived exertion. Med. Sci. Sports Exerc. 14:1982;377-381
31. Jones W.E., Vaigneur K., Young J., et al. The architectural impact of single photon transmission measurements on full ring 3D positron emission tomography. IEEE Nuclear Science Symposium and Medical Imaging Conference Record. 2:1995;1026-1030
32. Bailey D.L., Miller M.P., Spinks T.J., et al. Experience with fully 3D PET and implications for future high resolution 3D tomographs. Phys. Med. Biol. 43:1998;777-786
33. Spinks T.J., Jones T., Bloomfield P.M., et al. Physical characteristics of the ECAT EXACT3D positron tomograph. Phys. Med. Biol. 45:2000;2601-2618
34. Friston K.J., Frith C.D., Liddle P.F., et al. The relationship between local and global changes in PET scans. J. Cereb. Blood Flow Metab. 10:1990;458-466
35. Friston K.J., Frith C.D., Liddle P.F., et al. Comparing functional (PET) images: assessment of significant change. J. Cereb. Blood Flow Metab. 11:1991;690-699
36. Talairach J., Tournoux P. A co-planar stereotactic atlas of the human brain. 1988;Stuttgart, FRG, Thieme
37. Friston K.J., Passingham R.E., Nutt J.G., et al. Localisation in PET images: direct fitting of the intercommissural (AC-PC) line. J. Cereb. Blood Flow Metab. 9:1989;690-695
38. Kety S.S. Measurement of local blood flow by the exchange of an inert, diffusible substance. Meth. Med. Res. 8:1960;228-236
39. Veit R., Flor H., Erb M., et al. Brain circuits involved in emotional learning in antisocial behavior and social phobia in humans. Neurosci. Lett. 328:2002;233-236
40. Schneider F., Weiss U., Kessler C., et al. Subcortical correlates of differential classical conditioning of aversive emotional reactions in social phobia. Biol. Psychiatr. 45:1999;863-871
41. Critchley H.D., Corfield D.R., Chandler M.P., et al. Cerebral correlates of autonomic cardiovascular arousal: a functional neuroimaging investigation in humans. J. Physiol. 523:2001;259-270
42. 11C CGP-12177 to assess beta-adrenergic receptor concentration in idiopathic dilated cardiomyopathy. Circulation. 87:1993;1169-1178
43. Kawai C., Yui Y., Hoshino T., et al. Myocardial catecholamines in hypertrophic and dilated (congestive) cardiomyopathy: a biopsy study. J. Am. Coll. Cardiol. 2:1983;834-840
44. La Rovere M.T., Bigger J.T. Jr., Marcus F.I., et al. Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. Lancet. 351:1998;478-484
45. Cohn JN, Johnson GR, Shabetai R, et al. Ejection fraction, peak exercise oxygen consumption, cardiothoracic ratio, ventricular arrhythmias, and plasma norepinephrine as determinants of prognosis in heart failure. The V-HeFT VA Cooperative Studies Group. Circulation 1993;87(Suppl 6):VI5-16
46. Rundqvist B., Eisenhofer G., Elam M., et al. Attenuated cardiac sympathetic responsiveness during dynamic exercise in patients with heart failure. Circulation. 95:1997;940-945
47. Guzzetti S., Mezzetti S., Magatelli R., et al. Linear and non-linear 24 h heart rate variability in chronic heart failure. Auton. Neurosci. Bas. Clin. 86:2000;114-119
48. Paulson O.B., Jarden O.J., Vorstrup S., et al. Effect of captopril on the cerebral circulation in chronic heart failure. Eur. J. Clin. Invest. 16:1986;124-132
49. Paulson O.B., Waldemar G., Anderson A.R., et al. Role of angiotensin in autoregulation of cerebral blood flow. Circulation. 77:1988;I55-I58
50. Kamishirado H., Inoue T., Fujito T., et al. Effect of enalapril maleate on cerebral blood flow in patients with chronic heart failure. Angiology. 48:1997;707-713
51. Caparas S.N., Clair M.J., Krombach R.S., et al. Brain blood flow patterns after the development of congestive heart failure: effects of treadmill exercise. Crit. Care. Med. 28:2000;209-214