Potent inhibition of arterial intimal hyperplasia by TIMP1 gene transfer using AAV vectors

Molecular Therapy

Volumn 9, Issue 6, 2004, Pages 876-884

  Ramirez Correa, Genaro A ^a   Zacchigna, Serena ^a   Arsic, Nikola ^a   Zentilin, Lorena ^a   Salvi, Alessandro ^b   Sinagra, Gianfranco ^b   Giacca, Mauro ^a,c  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b MAGGIORE HOSPITAL   (Italy)

^c CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; COLLAGEN; ELASTIN; GELATINASE A; GELATINASE B; MATRIGEL; MATRIX METALLOPROTEINASE; METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL TISSUE; ARTERY INTIMA; ARTERY INTIMA PROLIFERATION; ARTERY MEDIA; ARTERY WALL; ARTICLE; CAROTID ARTERY INJURY; CELL MIGRATION; CONTROLLED STUDY; CORONARY ARTERY; DISEASE MODEL; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PROTEIN LOCALIZATION; RAT; RESTENOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; TRANSGENE; TREATMENT OUTCOME; VIRAL GENE DELIVERY SYSTEM; ZYMOGRAPHY;

ANGIOPLASTY, BALLOON; ANIMALS; ARTERIAL OCCLUSIVE DISEASES; CAROTID ARTERIES; COLLAGEN; DEPENDOVIRUS; ELASTIN; GENE THERAPY; GENETIC VECTORS; HUMANS; HYPERPLASIA; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MUSCLE, SMOOTH, VASCULAR; RATS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRANSFECTION; TUNICA INTIMA;

ADENO-ASSOCIATED VIRUS; ANIMALIA;

EID: 3042776198     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.02.020     Document Type: Article

References (45)

1. Topol E.J. Serruys P.W. Frontiers in interventional cardiology Circulation 98 1998 1802-1820
2. Clowes A.W. Schwartz S.M. Significance of quiescent smooth muscle migration in the injured rat carotid artery Circ. Res. 56 1985 139-145
3. Serruys P.W. et al. A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease. Benestent Study Group N. Engl. J. Med. 331 1994 489-495
4. Hoffmann R. et al. Patterns and mechanisms of in-stent restenosis: a serial intravascular ultrasound study Circulation 94 1996 1247-1254
5. Loscalzo J. Vascular matrix and vein graft failure: is the message in the medium? Circulation 101 2000 221-223
6. Libby P. Lee R.T. Matrix matters Circulation 102 2000 1874-1876
7. Feldman L.J. et al. Differential expression of matrix metalloproteinases after stent implantation and balloon angioplasty in the hypercholesterolemic rabbit Circulation 103 2001 3117-3122
8. de Smet B.J. et al. Metalloproteinase inhibition reduces constrictive arterial remodeling after balloon angioplasty: A study in the atherosclerotic Yucatan micropig Circulation 101 2000 2962-2967
9. Bendeck M.P. Zempo N. Clowes A.W. Galardy R.E. Reidy M.A. Smooth muscle cell migration and matrix metalloproteinase expression after arterial injury in the rat Circ. Res. 75 1994 539-545
10. Strauss B.H. et al. In vivo collagen turnover following experimental balloon angioplasty injury and the role of matrix metalloproteinases Circ. Res. 79 1996 541-550
11. George S.J. Johnson J.L. Angelini G.D. Newby A.C. Baker A.H. Adenovirus-mediated gene transfer of the human TIMP-1 gene inhibits smooth muscle cell migration and neointimal formation in human saphenous vein Hum. Gene Ther. 9 1998 867-877
12. Lijnen H.R. Soloway P. Collen D. Tissue inhibitor of matrix metalloproteinases-1 impairs arterial neointima formation after vascular injury in mice Circ. Res. 85 1999 1186-1191
13. Dollery C.M. Humphries S.E. McClelland A. Latchman D.S. McEwan J.R. Expression of tissue inhibitor of matrix metalloproteinases 1 by use of an adenoviral vector inhibits smooth muscle cell migration and reduces neointimal hyperplasia in the rat model of vascular balloon injury Circulation 99 1999 3199-3205
14. Turunen M.P. et al. Peptide-retargeted adenovirus encoding a tissue inhibitor of metalloproteinase-1 decreases restenosis after intravascular gene transfer Mol. Ther. 6 2002 306-312
15. Morishige K. et al. Overexpression of matrix metalloproteinase-9 promotes intravascular thrombus formation in porcine coronary arteries in vivo Cardiovasc. Res. 57 2003 572-585
16. Silence J. Collen D. Lijnen H.R. Reduced atherosclerotic plaque but enhanced aneurysm formation in mice with inactivation of the tissue inhibitor of metalloproteinase-1 (TIMP-1) gene Circ. Res. 90 2002 897-903
17. Lemaitre V. Soloway P.D. D'Armiento J. Increased medial degradation with pseudo-aneurysm formation in apolipoprotein E-knockout mice deficient in tissue inhibitor of metalloproteinases-1 Circulation 107 2003 333-338
18. Forough R. et al. Overexpression of tissue inhibitor of matrix metalloproteinase-1 inhibits vascular smooth muscle cell functions in vitro and in vivo Circ. Res. 79 1996 812-820
19. Monahan P.E. Samulski R.J. AAV vectors: is clinical success on the horizon? Gene Ther. 7 2000 24-30
20. Arsic N. et al. Induction of functional neovascularization by combined VEGF and angiopoietin-1 gene transfer using AAV vectors Mol. Ther. 7 2003 450-459
21. Forough R. et al. Metalloproteinase blockade by local overexpression of TIMP-1 increases elastin accumulation in rat carotid artery intima Arterioscler. Thromb. Vasc. Biol. 18 1998 803-807
22. Rolling F. Nong Z. Pisvin S. Collen D. Adeno-associated virus-mediated gene transfer into rat carotid arteries Gene Ther. 4 1997 757-761
23. Ward M.R. Pasterkamp G. Yeung A.C. Borst C. Arterial remodeling: mechanisms and clinical implications Circulation 102 2000 1186-1191
24. Galis Z.S. Khatri J.J. Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly Circ. Res. 90 2002 251-262
25. Hojo Y. Ikeda U. Katsuki T. Mizuno O. Fujikawa H. Shimada K. Matrix metalloproteinase expression in the coronary circulation induced by coronary angioplasty Atherosclerosis 161 2002 185-192
26. Kranzhofer A. Baker A.H. George S.J. Newby A.C. Expression of tissue inhibitor of metalloproteinase-1, -2, and -3 during neointima formation in organ cultures of human saphenous vein Arterioscler. Thromb. Vasc. Biol. 19 1999 255-265
27. Godin D. Ivan E. Johnson C. Magid R. Galis Z.S. Remodeling of carotid artery is associated with increased expression of matrix metalloproteinases in mouse blood flow cessation model Circulation 102 2000 2861-2866
28. Cho H.J. et al. Functional polymorphism in the promoter region of the gelatinase B gene in relation to coronary artery disease and restenosis after percutaneous coronary intervention J. Hum. Genet. 47 2002 88-91
29. Kuzuya M. et al. Deficiency of gelatinase a suppresses smooth muscle cell invasion and development of experimental intimal hyperplasia Circulation 108 2003 1375-1381
30. Galis Z.S. et al. Targeted disruption of the matrix metalloproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling Circ. Res. 91 2002 852-859
31. Cho A. Reidy M.A. Matrix metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury Circ. Res. 91 2002 845-851
32. Johnson C. Galis Z.S. Matrix metalloproteinase-2 and -9 differentially regulate smooth muscle cell migration and cell-mediated collagen organization Arterioscler. Thromb. Vasc. Biol. 2003
33. Bendeck M.P. Conte M. Zhang M. Nili N. Strauss B.H. Farwell S.M. Doxycycline modulates smooth muscle cell growth, migration, and matrix remodeling after arterial injury Am. J. Pathol. 160 2002 1089-1095
34. Wentzel J.J. et al. Shear-stress and wall-stress regulation of vascular remodeling after balloon angioplasty: effect of matrix metalloproteinase inhibition Circulation 104 2001 91-96
35. Lafont A. et al. Endothelial dysfunction and collagen accumulation: two independent factors for restenosis and constrictive remodeling after experimental angioplasty Circulation 100 1999 1109-1115
36. Sierevogel M.J. et al. Matrix metalloproteinase inhibition reduces adventitial thickening and collagen accumulation following balloon dilation Cardiovasc. Res. 55 2002 864-869
37. Baker A.H. Zaltsman A.B. George S.J. Newby A.C. Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro: TIMP-3 promotes apoptosis J. Clin. Invest. 101 1998 1478-1487
38. Raines E.W. Koyama H. Carragher N.O. The extracellular matrix dynamically regulates smooth muscle cell responsiveness to PDGF Ann. N. Y. Acad. Sci. 902 2000 39-51 discussion 51-32
39. Davenpeck K.L. et al. Regional differences in integrin expression: role of alpha(5)beta(1) in regulating smooth muscle cell functions Circ. Res. 88 2001 352-358
40. Stegemann J.P. Nerem R.M. Altered response of vascular smooth muscle cells to exogenous biochemical stimulation in two- and three-dimensional culture Exp. Cell Res. 283 2003 146-155
41. Ross J.J. Tranquillo R.T. ECM gene expression correlates with in vitro tissue growth and development in fibrin gel remodeled by neonatal smooth muscle cells Matrix Biol. 22 2003 477-490
42. Deodato B. et al. Recombinant AAV vector encoding human VEGF165 enhances wound healing Gene Ther. 9 2002 777-785
43. Zentilin L. Marcello A. Giacca M. Involvement of cellular double-strand DNA break-binding proteins in processing of recombinant adeno-associated virus (AAV) genome J. Virol. 75 2001 12279-12287
44. Chomczynski P. Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Anal. Biochem. 162 1987 156-159
45. Zacchigna S. et al. AAV-mediated gene transfer of tissue inhibitor of metalloproteinases-1 inhibits vascular tumor growth and angiogenesis in vivo Cancer Gene Ther. 11 2004 73-80