Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
WILLETT CG, BOUCHER E, DI TOMASO E et al.: Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat. Med. (2004) 10:145-147.
Vascular permeability factor/endothelial growth factor, a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
DVORAK HF: Vascular permeability factor/endothelial growth factor, a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J. Clin. Oncol. (2002) 20:4368-4380.
Phase II randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
KABBINAVAR F, HURWITZ HI, FEHRENBACHER L et al.: Phase II randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J. Clin. Oncol. (2003) 21:60-65.
Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
YUAN F, CHEN Y, DELLIAN M et al.: Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc. Natl. Acad. Sci. USA 93:14765-14770.
Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions
LEE C-G, HEIJY M, DI TOMASO E et al.: Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res. (2000) 60:5565-5570.
Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
GORDON MS, MARGOLIN K, TALPAZ M et al.: Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J. Clin. Oncol. (2001) 19:843-850.
A randomized trial of bevacizumab, and anti-vascular endothelial growth factor antibody, for metastatic renal cancer
YANG JC, HAWORTH L, SHERRY RM et al.: A randomized trial of bevacizumab, and anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N. Engl. J. Med. (2003) 349:427-434.
Resting and activated endothelial cells are increased in the peripheral blood of cancer cells
MANCUSO P, BURLINI A, PRUNERI G et al.: Resting and activated endothelial cells are increased in the peripheral blood of cancer cells. Blood (2001) 97:3658-3661.