Effects of aging on human skin innervation

NeuroReport

Volumn 15, Issue 1, 2004, Pages 149-153

  Chang, Yang Chyuan ^a   Lin, Whei Min ^b   Hsieh, Sung Tsang ^a,b  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Aging; Epidermal nerves; Protein gene product 9.5; Skin biopsy; Skin innervation; Ubiquitin; Unmyelinated nerves

Indexed keywords

ADULT; AGED; AGING; ARTICLE; CELL DENSITY; CONTROLLED STUDY; FEMALE; FOREARM; HUMAN; HUMAN EXPERIMENT; MALE; NERVE CELL; NERVE CELL NETWORK; NORMAL HUMAN; PRIORITY JOURNAL; SKIN BIOPSY; SKIN NERVE; COMPARATIVE STUDY; CONFIDENCE INTERVAL; INNERVATION; MIDDLE AGED; PHYSIOLOGY; SENSORY NERVE CELL; SKIN; STATISTICAL MODEL;

ADULT; AGED; AGING; CONFIDENCE INTERVALS; FEMALE; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; NEURONS, AFFERENT; SKIN;

EID: 3042742738     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001756-200401190-00029     Document Type: Article

References (24)

1. Light AR and Perl ER. Peripheral sensory systems. In: Dyck PJ, Thomas PK, Griffin JW, Low PA and Poduslo JF (eds). Peripheral Neurology. Philadelphia: W.B. Saunders; 1993, pp. 149-165.
2. Kenshalo DR, Sr. Somesthetic sensitivity in young and elderly humans. J Gerontol 41, 732-742 (1986).
3. Daselaar SM, Veltman DJ, Rombouts SA, Raaijmakers JG and Jonker C. Neuroanatomical correlates of episodic encoding and retrieval in young and elderly subjects. Brain 126, 43-56 (2003).
4. Kennedy WR and Wendelschafer-Crabb G. The innervation of human epidermis. J Neurol Sci 115, 184-190 (1993).
5. Lin WM, Hsieh ST, Huang IT, Griffin JW and Chen WP. Ultrastructural localization and regulation of protein gene product 9.5. Neuroreport 8, 2999-3004 (1997).
6. Verdu E, Buti M and Navarro X. Functional changes of the peripheral nervous system with aging in the mouse. Neurobiol Aging 17, 73-77 (1996).
7. Kanda T, Tsukagoshi H, Oda M, Miyamoto K and Tanabe H. Morphological changes in unmyelinated nerve fibres in the sural nerve with age. Brain 114, 585-599 (1991).
8. Bickel A, Butz M, Schmelz M, Handwerker HO and Neundorfer B. Density of sympathetic axons in sural nerve biopsies of neuropathy patients is related to painfulness. Pain 84, 413-419 (2000).
9. McCarthy B, Hsieh ST, Stocks EA, Hauer P, Macko C, Cornblath DR et al. Cutaneous innervation in sensory neuropathies: evaluation by skin biopsy. Neurol 45, 1848-1855 (1995).
10. Chien HF, Tseng TJ, Lin WM, Yang CC, Chang YC, Chen RC et al. Quantitative pathology of cutaneous nerve terminal degeneration in the human skin. Acta Neuropathol (Berl) 102, 455-461 (2001).
11. Chiang HY, Huang IT, Chen WP, Chien HF, Shun CT, Chang YC et al. Regional difference in epidermal thinning after skin denervation. Exp Neurol 154, 137-145 (1998).
12. Sowell ER, Peterson BS, Thompson PM, Welcome SE, Henkenius AL and Toga AW. Mapping cortical change across the human life span. Nature Neurosci 6, 309-315 (2003).
13. Hsieh ST, Chiang HY and Lin WM. Pathology of nerve terminal degeneration in the skin. J Neuropathol Exp Neurol 59, 297-307 (2000).
14. Kennedy WR, Wendelschafer-Crabb G and Johnson T. Quantitation of epidermal nerves in diabetic neuropathy. Neurology 47, 1042-1048 (1996).
15. Periquet MI, Novak V, Collins MP, Nagaraja HN, Erdem S, Nash SM et al. Painful sensory neuropathy: prospective evaluation using skin biopsy. Neurology 53, 1641-1547 (1999).
16. Ceballos D, Cuadras J, Verdu E and Navarro X. Morphometric and ultrastructural changes with ageing in mouse peripheral nerve. J Anal 195, 563-576 (1999).
17. McArthur JC, Stocks EA, Hauer P, Cornblath DR and Griffin JW. Epidermal nerve fiber density: normative reference range and diagnostic efficiency. Arch Neurol 55, 1513-1520 (1998).
18. Lauria G, Holland N, Hauer P, Cornblath DR, Griffin JW and McArthur JC. Epidermal innervation: changes with aging, topographic location, and in sensory neuropathy. J Neurol Sci 164, 172-178 (1999).
19. Johansson O, Wang L, Hilliges M and Liang Y. Intraepidermal nerves in human skin: PGP 9.5 immunohistochemistry with special reference to the nerve density in skin from different body regions. J Periph Nerv Syst 4, 43-52 (1999).
20. Pan CL, Lin YH, Lin WM, Tai TY and Hsieh ST. Degeneration of nociceptive nerve terminals in human peripheral neuropathy. Neuroreport 12, 787-792 (2001).
21. Cimino M, Cattabeni F, Di Luca M, Peruzzi G, Andena M, Tirassa P et al. Levels of NGF, p75NGFR and ChAT immunoreactivity in brain of adult and aged microencephalic rats. Neurobiol Aging 17, 137-142 (1996).
22. Anand P, Terenghi G, Warner G, Kopelman P, Williams-Chestnut RE and Sinicropi DV. The role of endogenous nerve growth factor in human diabetic neuropathy. Nature Med 2, 703-707 (1996).
23. Scott SA, Liang S, Weingartner JA and Crutcher KA. Increased NGF-like activity in young but not aged rat hippocampus after septal lesions. Neurobiol Aging 15, 337-346 (1994).
24. Hall KE, Sheng HC, Srinivasan S, Spitsbergen JM, Tuttle JB, Steers WD et al. Treatment of aged rat sensory neurons in short-term, serum-free culture with nerve growth factor reverses the effect of aging on neurite outgrowth, calcium currents, and neuronal survival. Brain Res 888, 128-137 (2001).