Treatment of aged rat sensory neurons in short-term, serum-free culture with nerve growth factor reverses the effect of aging on neurite outgrowth, calcium currents, and neuronal survival

Brain Research

Volumn 888, Issue 1, 2001, Pages 128-137

  Hall, Karen E ^a   Sheng, Huaibao C ^b   Srinivasan, Shanthi ^c   Spitsbergen, John M ^d   Tuttle, Jeremy B ^e   Steers, William D ^e   Wiley, John W ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b University of Louisville School of Medicine   (United States)

^c WASHINGTON UNIVERSITY   (United States)

^d WESTERN MICHIGAN UNIVERSITY   (United States)

^e UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Aging; Apoptosis; Calcium currents; Calcium signaling; Nerve growth factor; Neuronal development

Indexed keywords

CALCIUM CHANNEL L TYPE; NERVE GROWTH FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CURRENT; CALCIUM SIGNALING; CELL AGING; CELL SURVIVAL; CONTROLLED STUDY; CULTURE MEDIUM; MALE; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SPINAL GANGLION;

ANIMALS; APOPTOSIS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CELL AGING; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; GANGLIA, SPINAL; IN SITU NICK-END LABELING; MALE; MEMBRANE POTENTIALS; NERVE GROWTH FACTOR; NEURITES; NEURONS, AFFERENT; PATCH-CLAMP TECHNIQUES; RATS; RATS, INBRED BN; RATS, INBRED F344;

EID: 0035808556     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)03038-9     Document Type: Article

References (44)

1. The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development
2. Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence
3. Effects of aging and axotomy on the expression of neurotrophin receptors in primary sensory neurons
4. Synaptic loss in cognitively impaired aged rats is ameliorated by chronic human nerve growth factor infusion
5. Calcium: Still center-stage in hypoxic-ischemic neuronal cell death
6. Levels of NGF, p75NGFR and ChAT immunoreactivity in brain of adult and aged microencephalic rats
7. Calcium currents of embryonic and adult neurons in serum-free culture
8. 125I]nerve growth factor by cholinergic neurons and down-regulated TrkA expression in the medial septum of aged rats
9. Responses of mature and aged sympathetic neurons to laminin and NGF: An in vitro study
10. Rescue of alpha-SNS sodium channel expression in small dorsal root ganglion neurons after axotomy by nerve growth factor in vivo
11. Evidence for an age-related decline in intracellualr calcium buffering in sympathetic nerves
12. Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effect of axotomy on sympathetic ganglia
13. Reversal of spatial memory impairments in aged rats by nerve growth factor and neurotrophins 3 and 4/5 but not by brain-derived neurotrophic factor
14. Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons
15. Elevated intracellular calcium blocks programmed neuronal death
16. Collateral sprouting and responsiveness to nerve growth factor of aging neurons
17. Biochemical and anatomical effects of antibodies against nerve growth factor on developing rat sensory ganglia
18. Voltage-dependent calcium currents are enhanced in rat dorsal root ganglion neurones from the Bio/Bred Worchester diabetic rat
19. Enhancement of high threshold calcium currents in rat primary afferent neurons by constitutively active protein kinase C
20. Up-regulation of alpha1D Ca2+ channel subunit mRNA expression in the hippocampus of aged F344 rats
21. Tissue culture of mammalian autonomic neurons: Serum-free medium for sympathetic neurons
22. Effects of nerve growth factor on the survival of primary cultured adult and aged mouse sensory neurons
23. The effects of nerve growth factor on neurite outgrowth from cultured adult and aged mouse sensory neurons
24. Regulation by nerve growth factor of neuropeptide phenotypes in primary cultured sensory neurons prepared from aged as well as adult mice
25. A 'calcium set-point hypothesis' of neuronal dependence on neurotrophic factor
26. Age-related changes in levels of the beta-subunit of nerve growth factor in selected regions of the brain: Comparison between senescence-accelerated (SAM-P8) and senescence-resistant (SAM-R1)
27. 2+ determine nerve growth factor dependence of sympathetic ganglion cells
28. Sodium overload through voltage-dependent Na(+) channels induces necrosis and apoptosis of rat superior cervical ganglion cells in vitro
29. Effects of aging on the expression of neurotrophins and their receptors in the rat pituitary gland
30. Calcium currents in aged rat dorsal root ganglion neurons
31. Calcium-mediated mechanisms in chemically induced cell death
32. Age-related decrease of nerve growth factor-like immunoreactivity in the basal forebrain of senescence-accelerated mice
33. The effect of systemically administered recombinant human nerve growth factor in healthy human subjects
34. Evidence for age-associated reduction in acetylcholine release and smooth muscle response in the rat colon
35. Nerve growth factor regulates sympathetic ganglion cell morphology and survival in the adult mouse
36. Increased NGF-like activity in young but not aged rat hippocampus after septal lesions
37. Altered regulation of nerve growth factor secretion by cultured VSMCs from hypertensive rats
38. Serum from patients with Type 2 diabetes with neuropathy induced complement-independent, calcium-dependent apoptosis in cultured neuronal cells
39. Acetyl-L-carnitine treatment increases nerve growth factor levels and choline acetyltransferase activity in the central nervous system of aged rats
40. Veratridine delays apoptotic neuronal death induced by NGF deprivation through a Na(+)-dependent mechanism in rat cultured sympathetic neurons
41. Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro
42. 2+ channels in rat phaeochromocytoma cell lines
43. Differential up-regulation of sodium channel alpha- and beta 1-subunit mRNAs in cultured embryonic DRG neurons following exposure to NGF