Association of medically unexplained fatigue with ACE insertion/deletion polymorphism in Gulf War veterans

Muscle and Nerve

Volumn 30, Issue 1, 2004, Pages 38-43

  Vladutiu, Georgirene D ^a   Natelson, Benjamin H ^b  

^a UNIVERSITY AT BUFFALO   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Angiotensin converting enzyme; Chronic fatigue syndrome; Gulf War veterans; Metabolic myopathy; Physical endurance

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE;

ADULT; ARTICLE; CHRONIC FATIGUE SYNDROME; CONTROLLED STUDY; DNA POLYMORPHISM; FATIGUE; FEMALE; GENE DELETION; GENE FREQUENCY; GENE INSERTION; GENETIC RISK; GENOTYPE; HUMAN; IDIOPATHIC DISEASE; MAJOR CLINICAL STUDY; MALE; MUSCLE METABOLISM; MYOPATHY; PHYSICAL STRESS; PRIORITY JOURNAL; SOLDIER; WAR;

FATIGUE SYNDROME, CHRONIC; GENE DELETION; GENE FREQUENCY; GENOTYPE; HUMANS; PEPTIDYL-DIPEPTIDASE A; PERSIAN GULF SYNDROME; POLYMORPHISM, GENETIC; VETERANS;

EID: 3042731743     PISSN: 0148639X     EISSN: None     Source Type: Journal    
DOI: 10.1002/mus.20055     Document Type: Article

References (36)

1. Brimacombe M, Helmer D, Natelson BH. Clinical differences exist between patients fulfilling the 1988 and 1994 case definitions of chronic fatigue syndrome. J Clin Psychol Med Settings 2002;9:309-314.
2. Buchwald D, Cheney PR, Peterson DL, Henry B, Wormsley SB, Geiger A. A chronic illness characterized by fatigue, neurologic and immunologic disorders, and active human herpesvirus type 6 infection. Ann Intern Med 1992;116:103-113.
3. Buchwald D, Herrell R, Ashton S, Belcourt M, Schmaling K, Sullivan P, Neale M, Goldberg J. A twin study of chronic fatigue. Psychosom Med 2001;63:936-943.
4. Cappuccio FP, Cook DG, Atkinson RW, Strazzullo P. Prevalence, detection and management of cardiovascular risk factors in different ethnic groups in south London. Heart 1997;78:555-563.
5. Crisan D, Carr J. Angiotensin 1-converting enzyme: genotype and disease associations. J Mol Diagn 2000;2:105-115.
6. DeLuca J, Johnson SK, Natelson BH. Neuropsychiatric status of patients with chronic fatigue syndrome: an overview. Toxicol Ind Health 1994;10:513-522.
7. Fernandez-Sola J, Nicolas JM, Oriola J, Sacanella E, Estruch A, Rubin E, Urbano-Marquez A. Angiotensin-converting enzyme gene polymorphism is associated with vulnerability to alcoholic cardiomyopathy. Ann Intern Med 2002;137:321-326.
8. Fortina P, Conant R, Monokian G, Dotti G, Parrella T, Hitchcock W, Kant J, Scanlin T, Rappaport E, Schwartz E, Surrey S. Non-radioactive detection of the most common mutations in the cystic fibrosis transmembrane conductance regulator gene by multiplex allele-specific polymerase chain reaction. Hum Genet 1992;90:375-378.
9. Fukuda K, Strauss SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med 1994;121:953-959.
10. Gross M. Clinical heterogeneity and molecular mechanisms in inborn muscle AMP deaminase deficiency. J Inherit Metab Dis 1997;20:186-192.
11. Haley RW, Billecke S, La Du BN. Association of low PON1 type Q (Type A) arylesterase activity with neurologic symptom complexes in Gulf War veterans. Toxicol Appl Pharmacol 1999;157:227-233.
12. Ioannidis JPA, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG. Replication validity of genetic association studies. Nat Genet 2001;29:306-309.
13. Jason LA, Richman JA, Rademaker AW, Jordan KM, Plioplys AV, Taylor RR, McCready W, Huang C-F, Plioplys S. A community-based study of chronic fatigue syndrome. Arch Intern Med 1999;159:2129-2137.
14. Kang H, Mahan C, Lee K, Magee C, Murphy F. Illnesses among United States veterans of the Gulf war: a population-based survey of 30,000 veterans. J Occup Environ Med 2000;42:491-501.
15. Kang H, Natelson B, Mahan C, Lee K, Murphy F. Post-traumatic stress disorder and chronic fatigue syndrome-like illness among Gulf War veterans: a population-based survey of 30,000 veterans. J Epidemiol 2003;157:141-148.
16. Lange G, Tiersky LA, DeLuca J, Peckerman A, Pollet C, Policastro T, Scharer J, Ottenweller JE, Fiedler N, Natelson BH. Psychiatric diagnoses in Gulf War veterans with fatiguing illness. Psychiatry Res 1999;89:39-48.
17. Lieberman J, Bell DS. Serum angiotensin-converting enzyme as a marker for the chronic fatigue-immune dysfunction syndrome: a comparison to serum angiotensin-converting enzyme in sarcoidosis. Am J Med 1993;95:407-412.
18. McCauley LA, Joos SK, Barkhuizen A, Shuell T, Tyree WA, Bourdette DN. Chronic fatigue in a population-based study of Gulf War veterans. Arch Environ Health 2002;340-348.
19. Montgomery H, Marshall R, Hemingway H, Myerson S, Clarkson P, Dollery C, Hayward M, Holliman D, Jubb M, World M, Thomas E, Brynes A, Saeed N, Barnard M, Bell J, Prasad K, Rayson M, Talmud P, Humphries S. Human gene for physical performance. Nature 1998;393:221-222.
20. Myerson S, Hemingway H, Budget R, Martin J, Humphries S, Montgomery H. Human angiotensin I-converting enzyme gene and endurance performance. J Appl Physiol 1999;87:1313-1316.
21. Nakai K, Itoh C, Miura Y, Hotta K, Musha T, Itoh T, Miyakawa T, Iwasaki R, Hiramori K. Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese. Circulation 1994;90:2199-2202.
22. Narita M, Nishigami N, Narita N, Yamaguti K, Okado N, Watanabe Y, Kuratsune H. Association between serotonin transporter gene polymorphism and chronic fatigue syndrome. Biochem Biophys Res Commun 2003;311:264-266.
23. O'Donnell CJ, Lindpaintner K, Larson MG, Rao VS, Ordovas JM, Schaefer EJ, Myers RH, Levy D. Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation 1998;97:1766-1772.
24. Pollet C, Natelson BH, Lange G, Tiersky L, DeLuca J, Policastro T, Desai P, Ottenweller JE, Korn L, Fiedler N, Kipen H. Medical evaluation of Persian Gulf veterans with fatigue and/or chemical sensitivity. J Med 1998;29:101-113.
25. Rankinen W, Simoneau J, Maier-Lenz D, Rauramaa R, Rivera M. No association between the angiotensin-converting enzyme ID polymorphism and elite endurance athlete status. J Appl Physiol 2000;88:1571-1575.
26. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion-deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990;86:1343-1346.
27. Rigat B, Hubert C, Corvol P, Soubrier F. PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1). Nucleic Acids Res 1992;20:1433.
28. Shanmugam V, Sell KW, Saha BK. Mistyping ACE heterozygotes. PCR Meth Appl 1993;3:120-121.
29. Taggart RT, Smail D, Apolito C, Vladutiu GD. Novel mutations associated with carnitine palmitoyltransferase II deficiency. Hum Mutat 1999;13:210-220.
30. Tiret L, Rigat B, Visvikis S, Breda C, Corvol P, Cambien F, Soubrier F. Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet 1992;51:197-205.
31. Torpy DJ, Bachmann AW, Grice JE, Fitzgerald SP, Phillips PJ, Whitworth JA, Jackson RV. Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension. J Clin Endocrinol Metab 2001;86:3692-3700.
32. Uemura K, Nakura J, Kohara K, Miki T. Association of ACE I/D polymorphism with cardiovascular risk factors. Hum Genet 2000;107:239-242.
33. Vladutiu GD, Bennett MJ, Smail D, Wong L-J, Taggart RT, Lindsley HB. A variable myopathy associated with heterozygosity for the R503C mutation in the carnitine palmitoyltransferase II gene. Molec Genet Metab 2000;70:134-141.
34. Vockley J, Rinaldo P, Bennett MJ, Matern D, Vladutiu GD. Synergistic heterozygosity: disease resulting from multiple partial defects in one or more metabolic pathways. Mol Genet Metab 2000;71:10-18.
35. Williams A, Rayson M, Jubb M, World M, Woods D, Hayward M, Martin J, Humphries S, Montgomery H. The ACE gene and muscle performance. Nature 2000;403:614.
36. Zhang Q, Zhou X-D, Denny T, Ottenweller JE, Lange G, LaManca JJ, Pollet C, Gause WC, Natelson BH. Changes in immune parameters are seen in Gulf War veterans but not in civilians with chronic fatigue syndrome. Clin Diagn Lab Immunol 1999;6:6-13.